Absorbable biological membrane, preparation method and application thereof

A biofilm and derivative technology, applied in the field of medical devices, can solve the problems of membrane exposure and infection retention time, and achieve the effects of controllable degradation, improved bone quality, and strong mechanical properties

Active Publication Date: 2022-03-01
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the clinical use of absorbable biofilms, there are still problems such as membrane exposure and infection, membrane collapse and displacement, soft tissue infection, antigenicity, in vivo residence time of non-absorbable membranes, and in vivo maintenance time of absorbable membranes. A safe, effective, and cheaper absorbable biofilm is imminent

Method used

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  • Absorbable biological membrane, preparation method and application thereof
  • Absorbable biological membrane, preparation method and application thereof
  • Absorbable biological membrane, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077]The preparation of embodiment 1 absorbable biofilm

[0078] (1) Weigh 1 g of carboxymethyl cellulose and 1 g of alginic acid respectively, add 50 ml of water for injection, and swell overnight to form a solution.

[0079] (2) Weigh 1.2g of Fan's recombinant humanized collagen, add 50ml of water for injection to dissolve, add all of it to the above-mentioned solution A, and continue stirring and dispersing at 45°C for 0.5h at a stirring speed of 100 rpm. Get the mixed solution, then fill the mixed solution into the mold, put it in the refrigerator at 2-8°C for 10 hours, then transfer it to the refrigerator for freezing, the freezing temperature is -80°C, the freezing time is 2 hours, and then put it in the freeze dryer Drying for 28 hours yielded a lyophilized product.

[0080] (3) Soak the above freeze-dried product in a concentration of 2% carbodiethylamine for cross-linking for 30 hours, then transfer to a concentration of 3% calcium chloride and soak for 2 hours for ...

Embodiment 2

[0081] The preparation of embodiment 2 absorbable biofilm

[0082] (1) Weigh 0.8 g of hydroxypropyl cellulose and 1 g of chitosan, add 50 ml of water for injection and swell overnight to form a solution.

[0083] (2) Weigh 0.8g of Fan's recombinant humanized collagen, add 50ml of water for injection to dissolve, add all of it to the above-mentioned solution A, continue stirring and dispersing at 40°C for 0.6h, and the stirring speed is 120 rpm, Get the mixed solution, then fill the mixed solution into the mold, put it in the refrigerator at 2-8°C for 12 hours, then transfer it to the refrigerator for freezing, the freezing temperature is -80°C, the freezing time is 2 hours, and then put it in the freeze dryer After drying for 30 hours, a lyophilized product was obtained.

[0084] (3) Soak the above-mentioned lyophilized product in glutaraldehyde with a concentration of 3% for cross-linking for 30 hours, then transfer to a concentration of 4% manganese chloride and soak for 3 ...

Embodiment 3-21

[0085] Preparation of embodiment 3-21 absorbable biofilm

[0086] Examples 3-21 used the amount of raw materials described in Table 2, and used the method described in Example 1 to prepare absorbable biofilms.

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Abstract

The invention discloses an absorbable biological membrane as well as a preparation method and application thereof. The absorbable biological membrane is obtained by cross-linking collagen, cellulose derivatives and other polysaccharide substances by using a cross-linking agent. The absorbable biological membrane is obtained by utilizing a double-crosslinking technology, has the advantages of strong mechanical property, soft texture, toughness, low immunogenicity, controllable degradation and the like, has certain viscosity, can be effectively attached to a use part, is widely applied to the field of oral medicine such as periodontology, oral implantation and alveolar surgery, and has a wide application prospect. Moreover, the absorbable biological membrane can stabilize the bone grafting particles, so that the displacement of the bone grafting particles is avoided, the osteogenesis quality is improved, and the survival rate of the implant is greatly improved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an absorbable biofilm, a preparation method and an application thereof. Background technique [0002] Oral implant restoration technology is one of the important revolutions in the development of stomatology in the last century. Due to its good retention and realistic aesthetic effects, it has greatly improved the quality of life and mental state of patients with tooth defects. The long-term success rate of dental implants depends on many factors, including the choice of implant site, the state of soft and hard tissue morphology, whether the bone quality around the implant is intact, the amount of bone meal implanted, and so on. Dental implant technology has become a common method for tooth loss restoration. Clinically, due to the physiological bone resorption after tooth loss and the bone tissue defect in traumatic tooth loss, some alveolar ridges are often too low, too ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/26
CPCA61L27/58A61L27/50A61L27/26A61L2430/12C08L5/04C08L89/00C08L1/286C08L5/08C08L1/284
Inventor 范代娣康华平段志广古娟史静静严建亚
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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