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Preparation method of self-assembled microcapsule

A technology of microcapsules and self-assembly, which is applied in the field of preparation of self-assembled microcapsules, which can solve the problems that the production method cannot be produced in large quantities, and achieve the effects of easy industrial production, high yield, and good spheroidization

Active Publication Date: 2022-03-01
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with traditional microcapsules prepared using organic solvents, self-assembled microcapsules have the advantages of simple preparation process and no use of organic solvents. However, the limitation of production methods prevents mass production

Method used

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  • Preparation method of self-assembled microcapsule
  • Preparation method of self-assembled microcapsule
  • Preparation method of self-assembled microcapsule

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preparation example Construction

[0041] As an aspect of the present invention, a method for preparing self-assembled microcapsules, comprising the steps of:

[0042] S1. Preparation of nano-polymer capsule wall materials by polymerization

[0043]S1-1. Prepare polymer colloid particles by means of emulsion polymerization: Introduce nitrogen into the reactor in advance to eliminate oxygen, add half of the amount of polymerized monomer and water, start stirring, the stirring speed is 200-400rpm, add triggering agent and emulsifier, carry out the polymerization reaction, the polymerization temperature is 50-100 ℃, add the other half of the polymerized monomer after stirring for 15-25 minutes, and obtain the polymer colloidal particles after the reaction is complete; in this step, the polymerized monomer is divided into two additions Carrying out the polymerization reaction instead of adding the polymerized monomer at one time, the purpose is to make the particle size of the produced particles more uniform;

[0...

Embodiment 1

[0057] A kind of preparation method of self-assembled microcapsule

[0058] Step 1: Preparation of capsule wall material colloidal particles

[0059] First, pass nitrogen gas through a 500mL four-neck flask for 20min, and the temperature of the water bath is 85°C. Add 50mL of distilled water, 8g of styrene, 4.375g of butyl acrylate and 0.125g of acrylic acid, turn on the stirring paddle at a speed of 400r / min, stir for 20min, then add 0.1g of SDS (sodium dodecyl sulfate) and KPS (potassium persulfate) 0.1g, after reacting for 20min, add distilled water 50mL, styrene 8g, butyl acrylate 4.375g and acrylic acid 0.125g, react for 10h. figure 2 The scanning electron microscope image of the synthesized colloidal particles shows that the particle size of the colloidal particles of the capsule wall material is about 80nm;

[0060] Step 2: Adjustment of Colloidal Particles of Capsule Wall Material

[0061] Take out the colloidal particle dispersion of the capsule wall material and ...

Embodiment 2

[0066] A kind of preparation method of self-assembled microcapsule embedding Congo red dye

[0067] Step 1: Preparation of capsule wall material colloidal particles

[0068] First, pass nitrogen gas through a 500mL four-neck flask for 20min, and the temperature of the water bath is 85°C. Add 50mL of distilled water, 8g of styrene, 4.375g of butyl acrylate and 0.125g of acrylic acid, turn on the stirring paddle at a speed of 400r / min, stir for 20min, then add 0.1g of SDS (sodium dodecyl sulfate) and KPS (potassium persulfate) 0.1g, react for 20min, then add distilled water 50mL, styrene 8g, butyl acrylate 4.375g and acrylic acid 0.125g, react for 10h;

[0069] Step 2: Adjustment of Colloidal Particles of Capsule Wall Material

[0070] The colloidal particle dispersion was taken out and dialyzed with a dialysis bag for more than 3 days. Take a sample and measure its solid content, add distilled water, adjust the solid content of the colloidal particle dispersion to 4wt%, add ...

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Abstract

The invention discloses a preparation method of a self-assembled microcapsule. The preparation method comprises the following steps: S1, preparing nano polymer capsule wall material colloidal particles through polymerization; s1-1, preparing polymer colloidal particles in an emulsion polymerization manner; s1-2, the polymer colloidal particles are taken out and placed in a dialysis bag for dialysis with water, impurities are removed, and pure capsule wall material colloidal particles are obtained; and S2, spray-drying the capsule wall material by using a spray dryer to prepare the microcapsule. According to the method, the porosity of the microcapsule can be flexibly controlled by changing conditions such as the size of colloidal particles, the glass transition temperature of the colloidal particles and the temperature of a spray drying inlet, so that the effect of different slow release rates is achieved; according to the microcapsule prepared by the method, more than or equal to 90% of particles are spherical, and the diameter of the particles is 0.1-10 microns; when the microcapsule prepared by the method meets the slow release requirement, the microcapsule is added into the microcapsule or soaked in a specific organic solution, and the surface blocking reaction can block the embedded material, so that the release of the embedded material is slowed down or stopped.

Description

technical field [0001] The invention relates to the technical field of microcapsule preparation; more specifically, it relates to a method for preparing self-assembled microcapsules. Background technique [0002] Microcapsules usually refer to micro-containers with particle sizes in the nanometer or micrometer scale, composed of capsule wall materials and embedded substances, and are widely used in the fields of medicine, agriculture and chemical industry. The embedding of microcapsules can effectively improve the physical properties of the embedding or achieve the effect of sustained release. Ramsden and Pickering first reported the self-assembly process of colloidal particles at the oil-water interface to form a stable Pickering emulsion. Velev et al. used Pickering emulsion to prepare self-assembled microcapsules, and the colloidal particles in the outer shell were fixed by the deposition of polyelectrolytes. Dinsmore et al. invented a method of heating and fixing the s...

Claims

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Application Information

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IPC IPC(8): B01J13/04C08F212/08C08F220/18C08F220/06C08F220/14C08F220/34C08F220/56
CPCB01J13/043C08F212/08C08F220/14C08F220/1804C08F220/34C08F220/06C08F220/56
Inventor 陈建峰刘荣琨王洁欣孙倩贾佳
Owner BEIJING UNIV OF CHEM TECH
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