Two-photon fluorescent probe for double detection of sulfur dioxide and viscosity and preparation of two-photon fluorescent probe

A two-photon fluorescence, sulfur dioxide technology, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problem of not developing two-photon fluorescent probes, etc., and achieve large Stokes shift and biocompatibility. Good performance and stability
CN114149359AInactive Publication Date: 2022-03-08UNIV OF JINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF JINAN
Publication Date
2022-03-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a two-photon fluorescent probe for sulfur dioxide and viscosity dual detection and a preparation method of the two-photon fluorescent probe. The compound structure of the fluorescent probe is shown as a compound PVS. The fluorescent probe realizes two-photon excitation response to viscosity by utilizing a twisted intramolecular charge transfer (TICT) mechanism between indole salt and carbazole. Meanwhile, the carbon-carbon double bond connected with the indole salt can realize response to sulfur dioxide through nucleophilic addition reaction. The PVS has the advantages that the PVS can track the fluctuation of sulfur dioxide and viscosity at the same time, and has two emissions which are easy to distinguish. The PVS can also accurately visualize the form of the mitochondria, and the real-time accurate monitoring of the sulfur dioxide and the viscosity in the mitochondria under the excitation of the two photons is successfully realized.
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Description

technical field

[0001] The present invention relates to a small molecule fluorescent probe compound, more specifically a fluorescent probe for dual detection of sulfur dioxide and viscosity in mitochondria based on a two-photon compound that distorts the intramolecular charge transfer mechanism, and belongs to fluorescent sensor probe compounds field. Background technique

[0002] Mitochondria, as the "power factory" in cells, is an important place for material exchange and energy conversion in organisms, and participates in many physiological processes, such as signal transmission, cell differentiation, growth and death. The function of mitochondria is based on many important biomolecules, including various metal ions, reactive oxygen / nitrogen / sulfur species (ROS / RNS / RSS), etc. In addition, increased mitochondrial viscosity can lead to mutations in the mitochondrial reticulum, manifested by deterioration of mitochondrial morphology, which severely hinders material transpor...

Claims

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