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Drug sustained-release controllable polyether-ether-ketone implant and preparation method thereof

A polyetheretherketone and implant technology, which is used in drug delivery, pharmaceutical formulations, joint implants, etc., can solve the problems of easy detachment of the coating, too fast slow release time, uncontrollable porosity of pore-making technology, etc. , to achieve the effects of good biocompatibility, guaranteed mechanical properties, good interlayer bonding and printing accuracy

Active Publication Date: 2022-03-18
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above defects or improvement needs of the prior art, the present invention provides a polyetheretherketone implant with controlled drug release and a preparation method thereof. Its purpose is to use laser selective sintering to obtain the substrate of the drug-loaded area and the solid area, and use different porosity to regulate the slow-release rate and time of the drug or active factor, thereby solving the problem of existing surface coating drug-loading technology coatings. Technical problems such as easy falling off, too fast slow release time, uncontrollable porosity of pore-forming technology, and introduction of harmful groups

Method used

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  • Drug sustained-release controllable polyether-ether-ketone implant and preparation method thereof
  • Drug sustained-release controllable polyether-ether-ketone implant and preparation method thereof
  • Drug sustained-release controllable polyether-ether-ketone implant and preparation method thereof

Examples

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preparation example Construction

[0039] The present invention also provides a preparation method of a polyetheretherketone implant with controlled drug release, such as figure 1 As shown, the following steps are included:

[0040] (1) Select medical-grade polyether ether ketone, and conduct heat treatment to increase the sphericity of the powder.

[0041] (2) Acquire the model of the implant to be implanted, and divide the solid area and the drug-loaded area.

[0042] (3) Divide the model on the Z axis, set the layer thickness to 0.1mm, divide each layer into a physical scanning area and a drug-loaded scanning area according to the area divided in step (2), and set laser 1 to scan the physical scanning area, the laser 2 scans the drug-loaded scanning area, and sets the corresponding parameters. Then turn on the device for laser selective sintering printing. After printing, keep warm for 2 hours, then turn off the machine and cool down slowly.

[0043] (4) Perform sandblasting or air-jet treatment on the p...

Embodiment 1

[0068] This example provides a method for preparing a polyether ether ketone implant with controlled drug release, see figure 1 ,specifically:

[0069](1) Select 2 kg of medical-grade polyether ether ketone powder with a particle size of 30-70 μm, put it into an oven and heat-treat it in an argon atmosphere at 290° C. for 6 hours.

[0070] (2) The implanted body in this embodiment is an artificial vertebral body implanted in the cervical spine. According to the stress situation after numerical simulation, the entire vertebral body is divided into a drug-loaded area and a solid area, such as Figure 4 As shown in (a)-(c), it is exported as an STL format file on the "Magics" software.

[0071] (3) Process the imported STL file in the laser selective sintering equipment, and perform Z-axis division. Set each layer to 0.1mm, and divide each layer into a physical scanning area and a drug-loaded scanning area according to the area divided in step (2), set laser 1 to scan the physi...

Embodiment 2

[0078] This example provides a method for preparing a polyetheretherketone implant with controlled drug release, specifically:

[0079] (1) Select 2 kg of medical-grade polyether ether ketone powder with a particle size of 30-70 μm, put it into an oven and heat-treat it in an argon atmosphere at 250° C. for 10 h.

[0080] (2) The implant body of this embodiment is an artificial vertebral body implanted in the cervical spine, and the shape of the artificial vertebral body is designed, such as image 3 As shown in (a)-(d), according to the stress after numerical simulation, the whole vertebral body is divided into drug-loaded area and solid area, such as Figure 4 As shown in (a)-(c), it is exported as an STL format file on the "Magics" software.

[0081] (3) Process the imported STL file in the laser selective sintering equipment, and perform Z-axis division. Set each layer to 0.1mm, and divide each layer into a physical scanning area and a drug-loaded scanning area according...

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Abstract

The invention discloses a drug sustained-release controllable polyether-ether-ketone implant and a preparation method thereof. The implant comprises a drug loading area and a solid area, the solid area comprises a first polyether-ether-ketone substrate, and the drug loading area comprises a second polyether-ether-ketone substrate, a drug loading medium and a drug or an active factor loaded on the second polyether-ether-ketone substrate through the drug loading medium; the second polyether-ether-ketone substrate is provided with mutually communicated concave holes smaller than or equal to 10 microns, and the strength of the first polyether-ether-ketone substrate meets the requirement that the implant keeps the original structure during use; the first polyether-ether-ketone substrate and the second polyether-ether-ketone substrate are obtained through selective laser sintering printing. The slow release rate and time of drugs or active factors are regulated and controlled by using different porosities, and the technical problems that the coating is easy to fall off and the slow release time is too short in the existing surface coating drug-loading technology and the porosity is uncontrollable, harmful groups are introduced and the like in the conventional pore-forming technology are solved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a polyether ether ketone implant with controlled drug sustained release and a preparation method thereof. Background technique [0002] At present, with the development of social economy and the aggravation of population aging, the incidence of bone defects has increased sharply, and the demand for implanted scaffolds for bone defects in clinical treatment is also rising. One of the popular directions in the field. [0003] Polyetheretherketone (Poly-ether-ether-ketone, PEEK) is a kind of good biocompatibility, chemical stability, excellent mechanical properties, can be used for high temperature steam and gamma radiation disinfection, X-ray transparency polymer material. Therefore, medical-grade polyetheretherketone materials have been widely used in clinical practice in recent years. PEEK materials can be printed into personalized implants by laser selectiv...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/56A61L27/18A61L27/50A61L27/08A61L27/10A61L27/12A61L27/02A61L27/04A61F2/44A61F2/30
CPCA61L27/54A61L27/56A61L27/18A61L27/50A61L27/08A61L27/10A61L27/12A61L27/025A61L27/047A61F2/447A61F2/30942A61F2/30767A61L2430/02A61L2300/602A61L2300/416A61L2300/412A61L2300/102A61L2300/112A61L2300/10A61L2300/108A61L2400/12A61F2002/3097A61F2002/30976A61F2002/30985A61F2002/30784A61F2002/3093A61F2310/0097C08L61/16Y02P10/25
Inventor 闫春泽王浩则陈鹏苏瑾舒梓星吴思琪陈致远史玉升
Owner HUAZHONG UNIV OF SCI & TECH
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