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Microbial composition for regulating intestinal flora and preparation method thereof

A technology of microbial composition and intestinal flora, applied in the biological field, can solve the problems of complex selection of healthy individuals, different individuals, inability to accurately treat fecal microbiota transplantation, complex components of fecal microbiota transplantation, etc.

Inactive Publication Date: 2022-03-18
北京浩鼎瑞微生态科技研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The intestinal microecological regulation in the prior art relies more on the transplantation of the microbial environment of healthy individuals, but the screening of healthy individuals is more complicated and the differences among different individuals will lead to the influence of the microecological environment of healthy individuals on the intestinal microbiological environment of patients. Additional debuffs when biomorphing
At the same time, the composition of fecal bacteria transplantation is too complex to achieve quality control and precise intervention
Due to the uncertainty of the type and quantity of the flora, fecal microbe transplantation cannot be accurately treated according to the individual during clinical treatment, resulting in a decrease in the cure rate

Method used

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  • Microbial composition for regulating intestinal flora and preparation method thereof
  • Microbial composition for regulating intestinal flora and preparation method thereof
  • Microbial composition for regulating intestinal flora and preparation method thereof

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preparation example Construction

[0042]The invention provides a microbial composition for harmonizing intestinal flora, a screening method and a preparation method of the composition.

[0043] In the context of the present invention, FMT capsules refer to capsules containing normal faecal bacteria of healthy people after treatment, which contain whole strains of intestinal bacteria of healthy people. P-fhw refers to a probiotic composition.

[0044] At present, the main treatment drugs for irritable bowel syndrome include antidiarrheal drugs, antispasmodics, and antidepressants, and the treatment methods involve intestinal microecological treatment.

[0045] For example, in patients with chronic severe constipation who underwent a colonoscopic route of FMT plus a second-day fecal liquid enema, 40 patients (69%) experienced resolution of symptoms, including improved bowel movements, shortly after FMT , there was no abdominal distension and abdominal pain, and in the follow-up of 9-19 months, 18 patients had n...

Embodiment 1

[0053] The microbial composition involved in the P-fhw capsule can contain: Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Rhamnobacterium, milk of reuteri Bacillus, Lactobacillus helveticus in one or more. Preferably, the microbial composition comprises Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Rhamnobacterium rhamnosus, Lactobacillus reuteri, Lactobacillus helveticus.

[0054] According to a preferred embodiment, the composition ratio selected from Bifidobacterium strains, Lactobacillus strains and / or other genera strains with substantially the same properties can be: Bifidobacterium strains: Lactobacillus strains=1: 1. Preferably, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum,...

Embodiment 2

[0076] Although the above studies have initially suggested the possible therapeutic effect of "fecal microbiota transplantation" on IBS, the current understanding of fecal microbiota used for FMT treatment can hardly provide exact quantitative data or colonization quantitative indicators for this microbial population, and different supplies Therefore, it is difficult for fecal bacteria to meet the standards in terms of preparation, standard type and quality control. Therefore, there is an urgent need to accurately supplement the intestinal flora according to the stool changes of IBS patients. Selective Microbiaota Transplantation (SMT) is to cultivate quantitative and qualitative beneficial bacteria and provide them to patients to achieve Precise treatment for IBS patient groups.

[0077] The treatment process of fecal microbiota transplantation, that is, standard fecal microbiota transplantation, cannot control the type and amount of microorganisms administered to different p...

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Abstract

The present invention relates to a microbial composition for intestinal flora reconciliation comprising a strain of the genus Bifidobacterium, a strain of the genus Lactobacillus and / or a strain of other genus having substantially the same properties wherein the strain of the genus Bifidobacterium is selected from the group comprising Bifidobacterium breve, Bifidobacterium infantis and Bifidobacterium longum. The coprophilous fungus transplantation is a powerful means for achieving the purpose of disease treatment by adjusting the intestinal microecology. The transplanting components of coprophilous fungi are too complex, and quality controllability and accurate intervention cannot be realized. Therefore, through intestinal flora data mining and analysis, several core strains playing an important role in ecology are selected to realize regulation and control of the whole intestinal micro-ecology, so that alleviation and treatment of disease symptoms are realized.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a microbial composition for adjusting intestinal flora. Background technique [0002] Irritable bowel syndrome (Irritable Bowel Syndrome, IBS) is an intestinal stress response syndrome mainly manifested by abdominal pain, abdominal discomfort, changes in bowel habits or changes in stool properties. The global prevalence of IBS is 10%-20%. In recent years, it has been considered as a global functional disease with the highest incidence rate in humans. However, IBS is a multifactorial disease with complex etiology and pathophysiological mechanisms. Its pathogenic factors include intestinal flora dysbiosis, small intestinal bacterial Abnormal secretion and absorption function, intestinal barrier function damage, intestinal mucosal immune abnormality, brain-gut axis abnormality, etc., currently there is no effective treatment. Due to the multifactorial pathogenic mechanism of IBS, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/745A61K35/747A61K9/19A61P1/00C12R1/225C12R1/23C12R1/245C12R1/25C12R1/01
CPCC12N1/20A61K35/745A61K35/747A61K9/19A61P1/00A61K2300/00
Inventor 张洵孙龙
Owner 北京浩鼎瑞微生态科技研究院有限公司
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