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Microneedle patch, miniature blood glucose concentration detection system and biomarker detection system

A biomarker and detection system technology, applied in the field of microneedle patch, micro blood sugar concentration detection system and biomarker detection system, can solve the problems of insufficient mechanical strength and insufficient sampling volume, and achieve easy operation and simple preparation method , Improve swelling effect

Active Publication Date: 2022-03-25
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This application provides a microneedle patch, a micro blood sugar concentration detection system and a biomarker detection system to solve the problems of insufficient mechanical strength and insufficient sampling volume in the current microneedle patch sampling technology

Method used

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  • Microneedle patch, miniature blood glucose concentration detection system and biomarker detection system
  • Microneedle patch, miniature blood glucose concentration detection system and biomarker detection system
  • Microneedle patch, miniature blood glucose concentration detection system and biomarker detection system

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preparation example Construction

[0046] Further, the preparation method of the microneedle patch comprises:

[0047] heating polyvinyl alcohol to a molten state, and mixing it with a hydrophilic polymer solution at a mass ratio of 1:(0.15-1) to obtain a mixed solution;

[0048] Adding a crosslinking agent to the mixed solution to obtain a mixture; wherein, the amount of the crosslinking agent is 0.05wt% of the mixed solution;

[0049] The mixture is cast into a microneedle mold, dried and demoulded to obtain a microneedle patch.

[0050] The specific process conditions for drying and demolding are to dry the microneedle patch by normal temperature drying, oven drying or vacuum drying. After drying, the microneedle patch can maintain the original needle-shaped structure and thus be separated from the microneedle mold. .

[0051] Further, the molecular weight of the polyvinyl alcohol is 27000-98000, and the mass concentration is 7%-30%; the hydrophilic polymer is hyaluronic acid, dextran, chitosan, sodium alg...

Embodiment 1

[0059] A preparation method of a micro blood sugar concentration detection system based on skin interstitial fluid, comprising:

[0060] It is prepared by mixing polyvinyl alcohol (molecular weight: 27000, mass fraction 12%) and maltose solution at a mass ratio of 1:0.5 to obtain a mixed solution; the mixed solution is cast into a microstructure prepared from polydimethylsiloxane Needle molds (such as figure 1 ), centrifuge to make the solution enter the holes of the microneedle mold, dry at room temperature, and release the mold to obtain a hydrogel microneedle patch, such as figure 2 shown.

[0061] Insert the prepared hydrogel microneedle patch into the agarose hydrogel containing the target biomarker rhodamine B, keep it for 1-12min, and transfer the microneedle patch to phosphate buffer (pH=7.4) , heated in a water bath at 65°C to dissolve the tip of the microneedle patch, thereby releasing the target biomarker Rhodamine B, as shown in Figure 5 As shown, the results ...

Embodiment 2

[0063] A preparation method of a micro blood sugar concentration detection system based on skin interstitial fluid, comprising:

[0064] It is prepared by mixing polyvinyl alcohol (molecular weight: 89000, mass fraction 8%) and hyaluronic acid solution at a mass ratio of 1:1 to obtain a mixed solution; casting the mixed solution to a polydimethylsiloxane-prepared In the microneedle mould, the solution is centrifuged to enter the holes of the microneedle mould, vacuum-dried, and demolded to obtain a hydrogel microneedle patch.

[0065] Insert the prepared hydrogel microneedle patch into the agarose hydrogel containing the target biomarker rhodamine B, keep it for 1-12min, transfer the microneedle patch to normal saline, and heat it in a water bath at 70°C , so that the tip of the microneedle patch dissolves, thereby releasing the target biomarker rhodamine B, such as Figure 6 As shown, the results showed that the recovery rate of Rhodamine B was 63.3%.

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Abstract

The invention discloses a microneedle patch, a micro blood glucose concentration detection system and a biomarker detection system. The microneedle patch comprises a matrix, a patch body and a microneedle tip. The matrix is prepared from polyvinyl alcohol, a hydrophilic polymer solution and a cross-linking agent; the microneedle tip and the patch are integrally formed and are prepared by casting the matrix into a microneedle mold for drying and demolding; the cross-linking agent is one of boric acid, borax, glutaraldehyde and epoxy chloropropane; the miniature blood glucose concentration detection system comprises a microneedle patch and a detector, and the miniature blood glucose concentration detection system is used for sampling and detecting a biomarker in skin interstitial fluid to obtain a blood glucose value. The preparation method of the microneedle patch is simple, easy to operate and small in invasiveness, and the skin interstitial fluid can be extracted, recycled and detected within a short time.

Description

technical field [0001] The present application relates to the technical field of biomedical detection, in particular to a microneedle patch, a micro blood sugar concentration detection system and a biomarker detection system. Background technique [0002] Microneedle patches are composed of a series of micron-sized needles, which are painless, have no risk of infection, and are easy to use. Microneedle technology is one of the most innovative approaches in recent years and is currently being extensively investigated for the transdermal delivery of drugs, biotherapeutics, and vaccines. Recently, it has also been reported that microneedle patches can be used to collect interstitial fluid from the skin. Most of these microneedle patches are made of silicon, glass or metal, and can be divided into hollow microneedle patches and solid microneedle patches. The mechanism of the microneedle patch to collect the interstitial fluid of the skin is that the microneedle patch can produc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145
CPCA61B5/14503A61B5/14532A61B5/14514A61B2562/12Y02A50/30
Inventor 张鹏徐娜宁宗超
Owner SHENYANG PHARMA UNIVERSITY
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