Biodegradable injection filler microsphere as well as preparation method and application thereof

A filler and microsphere technology, applied in the field of medical cosmetic materials, can solve problems such as unfavorable human health and its industrial application, incomplete removal of residual solvent in freeze-drying process, uneven particle density of PLLA microspheres, etc. Side effects such as nodules, reduction of microbial and bacterial endotoxin levels, and improved quality uniformity

Pending Publication Date: 2022-03-25
MEIYAN SPACE (HEBEI) BIOTECHNOLOGY CO LTD +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is a one-step synthesis method, and the quality control of PLLA microspheres and their particle size is not carried out. The particle density of PLLA microspheres is not uniform, and subcutaneous nodules are prone to occur after injection. The residual solvent in the freeze-drying process is not completely removed, which affects the user experience. effect, not conducive to human health and its industrial application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable injection filler microsphere as well as preparation method and application thereof
  • Biodegradable injection filler microsphere as well as preparation method and application thereof
  • Biodegradable injection filler microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Example 1 Preparation of PLLA microspheres

[0082] (1) Water phase preparation: add 62.5g of methylcellulose into 25L of purified water, stir at 200rpm, and dissolve;

[0083] (2) Organic phase preparation: add 250g of poly-L-lactic acid into 2.5L of dichloromethane organic solvent, and stir until completely dissolved;

[0084] (3) Emulsification and granulation: mix the organic phase and the aqueous phase with a volume ratio of 1:20 evenly, homogenize at 10000 rpm for 3 minutes, and stir overnight;

[0085] (4) Refining treatment: collect the microspheres by filtration, add 5L of absolute ethanol solution to wash, filter, rinse the filter cake with absolute ethanol, sieve through 200 mesh and 400 mesh sieves, dry at 50°C for 24 hours, and obtain the particle size Microspheres of 20-60 μm.

Embodiment 2

[0086] Example 2 Preparation of PLLA microspheres

[0087] (1) Water phase preparation: add 62.5g of methylcellulose into 25L of purified water, stir at 500rpm, and dissolve;

[0088] (2) Organic phase preparation: add 250g of poly-L-lactic acid into 2.5L of dichloromethane organic solvent, and stir until completely dissolved;

[0089] (3) Emulsification and granulation: mix the organic phase and the aqueous phase with a volume ratio of 1:10 evenly, homogenize at 12000 rpm for 6 minutes, and stir overnight;

[0090] (4) Refining treatment: collect the microspheres by filtration, add 5L of absolute ethanol solution to wash, filter, rinse the filter cake with absolute ethanol, sieve through 200 mesh and 400 mesh sieves, dry at 50°C for 24 hours, and obtain the particle size Microspheres of 20-60 μm.

Embodiment 3

[0091] Example 3 Preparation of PLLA Microspheres

[0092] (1) Water phase preparation: add 62.5g of methylcellulose into 25L of purified water, stir at 300rpm, and dissolve;

[0093] (2) Organic phase preparation: add 250g of poly-L-lactic acid into 2.5L of dichloromethane organic solvent, and stir until completely dissolved;

[0094] (3) Emulsification and granulation: mix the organic phase and the aqueous phase with a volume ratio of 1:6 evenly, homogenize at 15000 rpm for 3 minutes, and stir overnight;

[0095] (4) Refining treatment: collect the microspheres by filtration, add 5L of absolute ethanol solution to wash, filter, rinse the filter cake with absolute ethanol, sieve through 200 mesh and 400 mesh sieves, dry at 50°C for 24 hours, and obtain the particle size Microspheres of 20-60 μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

According to the biodegradable injection filler microspheres and the preparation method and application thereof, the obtained PLLA microspheres are more regular in shape, more uniform in particle size distribution and higher in purity, the quality uniformity, controllability and safety of the PLLA microspheres during preparation of the injection filler are improved, and industrialization and industrial production of the PLLA injection filler are facilitated.

Description

technical field [0001] The invention relates to a biodegradable injection filler microsphere, a preparation method and an application thereof, and belongs to the field of medical cosmetic materials. Background technique [0002] Injectable fillers (also known as dermal fillers, soft tissue fillers) are mainly used to treat congenital defects and acquired defects. In recent years, they are mostly used in the field of medical cosmetology, such as filling and repairing skin wrinkles and depressions. An ideal injectable filler has the following characteristics: ① safe, little damage, good biocompatibility, not easy to infect or induce allograft granuloma; ② good stability, not easy to move, and can maintain a fixed volume and flexibility; ③ not Will be phagocytized by phagocytes; ④ Effectively promote collagen regeneration, naturally and continuously change facial contours, improve skin elasticity and moisture filling. Biodegradable injectable fillers include collagen, hyaluron...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/18A61L27/20A61L27/16A61L27/50A61L27/58
CPCA61L27/18A61L27/20A61L27/16A61L27/50A61L27/58A61L2400/06A61L2430/34C08L67/04
Inventor牛玉乐王晓平王宏郑金敏王爽纪蕾梁晓东邓声菊刚梁
OwnerMEIYAN SPACE (HEBEI) BIOTECHNOLOGY CO LTD