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Blood fat adsorbent and preparation method thereof

An adsorbent and blood lipid technology, which is applied in the field of blood lipid adsorbent and its preparation, can solve the problems that the spraying process of tertiary amine reagent is not easy to operate, affect the environment and reaction results, and cannot obtain blood lipid adsorbent, etc., so as to improve the reaction rate and ligand. Utilization rate, lowering reaction temperature, increasing the effect of fixed amount

Pending Publication Date: 2022-03-29
WUHAN RUIFA MEDICAL DEVICES CO LTD
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Problems solved by technology

However, in the actual coupling reaction, the utilization rate of the ligand dextran sulfate is less than 1%, and the effective blood lipid adsorbent cannot be obtained when the reacted ligand solution is reused. It can be seen that the reaction efficiency of the coupling reaction Low and low ligand utilization
However, there are obvious technical defects in this preparation method, the operation steps are complicated, the tertiary amine reagent spray process is not easy to operate, and it is easy to cause reagent volatilization, which affects the environment and reaction results.

Method used

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  • Blood fat adsorbent and preparation method thereof
  • Blood fat adsorbent and preparation method thereof

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preparation example Construction

[0028] The invention provides a preparation method of a blood lipid adsorbent, comprising the following steps:

[0029] S1, using polyepoxy glyceryl ether to activate the adsorption carrier to obtain an activated carrier containing polyepoxy groups;

[0030] S2, adding the lipid adsorption ligand into the acidic solution to obtain a ligand solution;

[0031] S3, adding the epoxy group-containing activated carrier obtained in step S1 to the ligand solution obtained in step S2, mixing and stirring to carry out coupling reaction, after the reaction is completed, solid-liquid separation, cleaning and drying are performed to obtain a blood lipid adsorbent.

[0032] Preferably, in step S1, the polyglycidyl ethers include but not limited to trimethylolpropane triglycidyl ether, glycerol triglycidyl ether, castor oil triglycidyl ether and triisocyanurate One or more mixtures of glycidyl ethers.

[0033] Preferably, in step S1, the activation carrier containing polyepoxy groups inclu...

Embodiment 1

[0045] Embodiment 1 of the present invention provides a preparation method of a blood lipid adsorbent, comprising the following steps:

[0046] S1, take a certain amount of agarose microspheres, add trimethylolpropane triglycidyl ether with a ratio of 1g:1.0mL to the agarose microspheres, mix well, react at 50°C for 2h, wash and drain, Obtain activated agarose microspheres containing multiple epoxy groups;

[0047] S2, dissolving heparin in a hydrochloric acid solution with a pH value of 4 at a ratio of 200mg: 1mL to prepare a heparin ligand solution;

[0048] S3, the ratio of the activated agarose microspheres to the heparin ligand solution is 1g: 3.0mL, which is added to the heparin ligand solution, and the coupling reaction is carried out at 50°C for 10 hours, followed by purified water and saline 1. Washing the adsorption carrier with purified water to obtain a blood lipid adsorbent.

Embodiment 2

[0050] Compared with Example 1, the difference is that the ratio in step S1 is replaced by 1 g: 2.0 mL.

[0051] Others are basically the same as in Embodiment 1, and will not be repeated here.

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Abstract

The invention provides a blood fat adsorbent and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out an activation reaction on an adsorption carrier by using polyepoxy glyceryl ether to obtain an activated carrier containing polyepoxy groups; adding a ligand into an acid solution to obtain a ligand solution; and adding the obtained activated carrier containing multiple epoxy groups into a ligand solution, mixing and stirring to perform a coupling reaction, and after the reaction is completed, performing solid-liquid separation, cleaning and drying to obtain the blood fat adsorbent. The coupling reaction is carried out under the acidic condition, and the acid is used as a catalyst for coordinating oxygen atoms of epoxy groups and promoting ring opening, so that the reaction rate of the coupling reaction and the utilization rate of ligands can be improved, the reaction temperature can be reduced, a complex catalyst is not used, pollution is reduced, the cost is saved, and the adsorption efficiency of the adsorbent is improved.

Description

technical field [0001] The invention relates to the technical field of preparation of medical adsorbents, in particular to a blood lipid adsorbent and a preparation method thereof. Background technique [0002] As we all know, cardiovascular and cerebrovascular diseases are a common disease that seriously threatens the health of human beings, especially middle-aged and elderly people over 50 years old. It has the characteristics of high prevalence, high disability rate and high mortality rate. The number of people who die from cardiovascular and cerebrovascular diseases is as high as 15 million every year in the world, ranking first among various causes of death. [0003] According to GBD data in 2017, elevated low-density lipoprotein (LDL-C) levels are the third largest attributable risk factor for cardiovascular disease in China, second only to high blood pressure and high-sodium diet. Low-density lipoprotein is a kind of lipoprotein particles that carry cholesterol into ...

Claims

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Application Information

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IPC IPC(8): B01J20/24B01J20/30
CPCB01J20/24
Inventor 毕红艳张磊余曾成陈梦林王业富
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
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