Blood fat adsorbent and preparation method thereof

An adsorbent and blood lipid technology, which is applied in the field of blood lipid adsorbent and its preparation, can solve the problems that the spraying process of tertiary amine reagent is not easy to operate, affect the environment and reaction results, and cannot obtain blood lipid adsorbent, etc., so as to improve the reaction rate and ligand. Utilization rate, lowering reaction temperature, increasing the effect of fixed amount

Pending Publication Date: 2022-03-29

WUHAN RUIFA MEDICAL DEVICES CO LTD

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AI-Extracted Technical Summary

Problems solved by technology

However, in the actual coupling reaction, the utilization rate of the ligand dextran sulfate is less than 1%, and the effective blood lipid adsorbent cannot be obtained when the reacted ligand solution is reused. It can be seen that the reaction efficiency of the coupling reaction Low and lo...

Method used

By adopting above-mentioned technical scheme, the present invention uses many epoxy glyceryl ethers to activate adsorption carrier, obtains the activation carrier containing many epoxy groups, provides a plurality of epoxy groups, is conducive to improving coupling reaction rate and ligand utilization, improve the adsorption performance of the adsorbent, and save costs.

In step S3, carry out coupling reaction under acidic condition, acid is as catalyzer, can coordinate the oxygen atom of epoxy group, and then impels epoxy group ring-opening and blood lipid adsorption ligand to take place coupling reaction, can significantly Improve the reaction rate and ligand utilization of the coupling reaction, and improve the adsorption efficiency of the adsorbent. Coupling under acidic conditions, reducing the reaction temperature, can properly reduce the coupling...

Abstract

The invention provides a blood fat adsorbent and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out an activation reaction on an adsorption carrier by using polyepoxy glyceryl ether to obtain an activated carrier containing polyepoxy groups; adding a ligand into an acid solution to obtain a ligand solution; and adding the obtained activated carrier containing multiple epoxy groups into a ligand solution, mixing and stirring to perform a coupling reaction, and after the reaction is completed, performing solid-liquid separation, cleaning and drying to obtain the blood fat adsorbent. The coupling reaction is carried out under the acidic condition, and the acid is used as a catalyst for coordinating oxygen atoms of epoxy groups and promoting ring opening, so that the reaction rate of the coupling reaction and the utilization rate of ligands can be improved, the reaction temperature can be reduced, a complex catalyst is not used, pollution is reduced, the cost is saved, and the adsorption efficiency of the adsorbent is improved.

Application Domain

Other chemical processes

Technology Topic

Blood lipidsCoupling reaction +6

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Examples

Experimental program(5)
Comparison scheme(2)

Example Embodiment

[0028] The invention provides a preparation method of a blood lipid adsorbent, comprising the following steps:

[0029] S1, use polyepoxy glycerol ether to carry out the activation reaction on the adsorption carrier to obtain the activated carrier containing polyepoxide;

[0030] S2, adding the blood lipid adsorption ligand into the acidic solution to obtain a ligand solution;

[0031] S3, the epoxy-containing activated carrier obtained in step S1 is added to the ligand solution obtained in step S2, and the coupling reaction is carried out with mixing and stirring. After the reaction is completed, solid-liquid separation, cleaning and drying are performed to obtain a blood lipid adsorbent.

[0032] Preferably, in step S1, the polyglycidyl ethers include but are not limited to trimethylolpropane triglycidyl ether, glycerol triglycidyl ether, castor oil triglycidyl ether and triglycidyl isocyanurate One or more of glycidyl ethers are mixed.

[0033] Preferably, in step S1, the polyepoxy-containing activation carrier includes, but is not limited to, polyepoxy-containing agarose microspheres, polyepoxy-containing cellulose microspheres, polyepoxy-containing One or more of the polylactic acid microspheres are mixed.

[0034] Preferably, the activation carrier containing polyepoxide groups is agarose microspheres containing polyepoxide groups. For example, using trimethylolpropane triglycidyl ether to activate sepharose microspheres to obtain agarose gel microspheres containing polyepoxide groups.

[0035] Preferably, the solid-liquid ratio of the adsorption carrier to the polyepoxy glycerol ether is 1 g: (0.1-5.0) mL.

[0036] Preferably, in step S2, the blood lipid adsorption ligand is heparin solution.

[0037] Preferably, in step S2, the acidic solution includes, but is not limited to, a mixture of one or more of acetic acid solution, hydrochloric acid solution, sulfuric acid solution, and Lewis acid solution.

[0038] Preferably, in step S2, the pH value of the acidic solution is 2-6.5.

[0039] Preferably, in step S3, the temperature of the coupling reaction is 30-80°C, and the time is 2-24 h.

[0040] Preferably, in step S3, the solid-to-liquid ratio of the polyepoxy-containing activation carrier to the ligand solution is 1 g: (0.3-6.0) mL.

[0041] By adopting the above technical scheme, the present invention uses polyepoxy glycerol ether to activate the adsorption carrier to obtain an activated carrier containing polyepoxy groups, providing multiple epoxy groups, which is beneficial to improve the coupling reaction rate and ligand. utilization rate, improve the adsorption performance of the adsorbent, and save costs.

[0042]In step S3, the coupling reaction is carried out under acidic conditions, and the acid is used as a catalyst to coordinate the oxygen atom of the epoxy group, thereby promoting the ring-opening of the epoxy group and the coupling reaction of the lipid adsorption ligand, which can significantly improve the coupling. The reaction rate and ligand utilization rate of the reaction improve the adsorption efficiency of the adsorbent. Coupling under acidic conditions and lowering the reaction temperature can appropriately reduce the coupling reaction temperature to prevent the agarose microspheres from dissolving in an aqueous solution with an excessively high temperature, which affects the adsorption performance of the final adsorbent. The reaction does not use complex catalysts. Reduce pollution and save costs.

Example Embodiment

[0044] Example 1

[0045] Embodiment 1 of the present invention provides a preparation method of a blood lipid adsorbent, comprising the following steps:

[0046] S1, take a certain amount of agarose microspheres, add trimethylolpropane triglycidyl ether in a ratio of 1 g to agarose microspheres: 1.0 mL, mix well, react at 50 °C for 2 hours, wash and drain, Activated polyepoxy-containing agarose microspheres are obtained;

[0047] S2, dissolving heparin in a hydrochloric acid solution with a pH value of 4 at a ratio of 200 mg: 1 mL to prepare a heparin ligand solution;

[0048] S3, the ratio of the activated agarose microspheres to the heparin ligand solution is 1 g: 3.0 mL, adding it to the heparin ligand solution, and performing a coupling reaction at 50° C. for 10 hours, followed by purified water and saline. and purified water to wash the adsorption carrier to obtain a blood lipid adsorbent.

Example Embodiment

[0049] Example 2

[0050] Compared with Example 1, the difference is that the ratio in step S1 is replaced by 1 g: 2.0 mL.

[0051] Others are basically the same as those in Embodiment 1, and are not repeated here.

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Classification and recommendation of technical efficacy words

low reaction temperature

Blood fat adsorbent and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

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Examples

Example Embodiment

Example Embodiment

Example Embodiment

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Description & Claims & Application Information

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