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Method for constructing metal-organic molecule compound and inorganic phase hybrid functional coating on degradable metal surface

A technology of organic molecules and construction methods, applied in coatings, medical science, prostheses, etc., can solve the problems of inability to take into account the regulation of zinc-based degradable metal corrosion behavior, the improvement of biocompatibility, and the lack of biological functionality. Achieve the effect of ensuring biocompatibility, stable and firm properties, and good osseointegration

Active Publication Date: 2022-04-12
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above problems, the present invention provides a method for constructing metal-organic molecular composites and inorganic phase hybrid functional coatings on the surface of degradable metals, so as to solve the problems of zinc-based degradable metals in the existing surface modification technology. Regulation of corrosion behavior and improvement of biocompatibility, as well as the problem of insufficient biological functionality

Method used

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  • Method for constructing metal-organic molecule compound and inorganic phase hybrid functional coating on degradable metal surface
  • Method for constructing metal-organic molecule compound and inorganic phase hybrid functional coating on degradable metal surface
  • Method for constructing metal-organic molecule compound and inorganic phase hybrid functional coating on degradable metal surface

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Embodiment 1

[0040] A method for constructing a metal-organic molecular compound and an inorganic phase hybrid functional coating on a degradable metal surface, comprising the steps of:

[0041](1) Pre-treatment: Polish the pure zinc disc with 600#, 1200#, 2000# sandpaper in turn, and clean it with absolute ethanol under ultrasonic for 3 times, each time for 5 minutes, and dry it to the surface at room temperature liquid evaporates;

[0042] (2) Preparation of zinc phosphate primer: mix 7.5mg / ml NaH 2 PO 4 and 2mg / ml of Zn(NO 3 ) 2 ·6H 2 After the O solution was mixed at a volume ratio of 5:2, it was placed in a water bath at 50°C for 2 hours, and then the dried zinc flakes in step (1) were placed in it, heated and reacted at 50°C for 2 hours, then removed and rinsed with water. Then place it in a 37°C constant temperature drying oven to dry until the surface liquid evaporates;

[0043] (3) Mix ferulic acid, hydroxyethylidene diphosphoric acid and water according to the material-liqu...

Embodiment 2

[0048] A method for constructing a metal-organic molecular compound and an inorganic phase hybrid functional coating on a degradable metal surface, comprising the steps of:

[0049] (1) Pre-treatment: Polish the pure magnesium sample with 600#, 1200#, 2000# sandpaper successively, and wash it with absolute ethanol under ultrasonic for 3 times, each time for 4 minutes, and dry it at room temperature until the surface becomes liquid. Volatile;

[0050] (2) Preparation of zinc phosphate primer: mix 6mg / ml Na 2 HPO 4 and 1mg / ml of Zn(NO 3 )·6H 2 After the O solution was mixed at a volume ratio of 5:2, it was placed in a water bath at 50°C for 2 hours, and then the sample dried in step (1) was placed in it, heated and reacted at 60°C for 1.5 hours, then removed and rinsed with water. Then dry at room temperature until the surface liquid evaporates;

[0051] (3) Mix ferulic acid, hydroxyethylidene diphosphoric acid and water according to the material-liquid ratio of 1.5mg:1mg:1...

Embodiment 3

[0056] A method for constructing a metal-organic molecular compound and an inorganic phase hybrid functional coating on a degradable metal surface, comprising the steps of:

[0057] (1) Pre-treatment: Polish the pure iron sample to remove the surface oxide layer to expose the pure iron, and clean it with absolute ethanol under ultrasonic for 3 times, each time for 6 minutes, and dry it at room temperature until the surface liquid volatilizes;

[0058] (2) Preparation of zinc phosphate primer: mix 9mg / ml Na 2 HPO 4 and 3mg / ml Zn(NO 3 )·6H 2 After mixing the O solution at a volume ratio of 5:2, place it in a water bath at 50°C for 2 hours, then place the dried pure magnesium sample in step (1), heat and react at 40°C for 2.5 hours, then take it out and rinse with water Clean, then dry at room temperature until the surface liquid evaporates;

[0059] (3) Mix ferulic acid, hydroxyethylidene diphosphoric acid and water according to the material-liquid ratio of 5mg:2mg:1ml, stir...

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Abstract

The invention discloses a method for constructing a metal-organic molecule compound and inorganic phase hybrid functional coating on a degradable metal surface, which comprises the following steps: generating a rough and stable inorganic zinc phosphate coating on an untreated degradable metal surface by a liquid phase chemical deposition method; and then the degradable metal with the inorganic zinc phosphate coating on the surface is circularly and alternately evaporated and deposited in a collagen / ferulic acid / hydroxyethylidene-1, 1-diphosphonic acid mixed solution and a metal ion solution, and the metal-organic molecule compound and inorganic phase hybrid functional coating is obtained. Through chemical coordination among organic functional molecules, metal ions and inorganic components, the metal-organic molecule compound and inorganic phase hybrid functional coating which is compact and uniform and has high hydrophilicity and surface energy is formed by compounding and hybridizing; while corrosion and degradation control and biocompatibility of degradable metal are considered, the composite material also has relatively good biological functions of osseointegration, bone regeneration, vascular regeneration, antibiosis and anti-inflammation.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a method for constructing a metal-organic molecular compound and an inorganic phase hybrid functional coating on a degradable metal surface. Background technique [0002] Compared with traditional metal implant materials, degradable metal as a temporary implant has significant advantages such as avoiding secondary surgery and accelerating the healing process, thereby greatly reducing the risk. Based on the above advantages, degradable zinc materials have gradually entered people's field of vision and attracted widespread attention. So far, degradable metals are mainly classified into magnesium, iron, and zinc. Compared with magnesium and iron, the degradable metal zinc is expected to be used in the treatment of orthopedic diseases and cardiovascular diseases due to its relatively moderate corrosion rate and potential biological functionality. However, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/28A61L27/30A61L27/04A61L27/50A61L27/54A61L27/58
Inventor 万国江王鹏钱军余张文泰王佳乐林雪毛金龙黄楠
Owner SOUTHWEST JIAOTONG UNIV
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