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Multifunctional polymeric polyurethane prodrug polymer nano diagnosis and treatment agent

A polymeric, polyurethane technology, applied in the field of medicine, can solve the problems of cisplatin side effects and drug resistance, carrier side effects, low loading capacity, etc., to overcome the complex construction process, high drug loading capacity, and simple method easy-to-use effects

Pending Publication Date: 2022-05-10
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inventors have found that: currently, the polymeric prodrug nanomedicine based on integrated nanotherapy chemotherapy combined with photothermal therapy still has low loading capacity, carrier side effects, side effects and drug resistance of cisplatin, and the efficacy of a single treatment. Bad question

Method used

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  • Multifunctional polymeric polyurethane prodrug polymer nano diagnosis and treatment agent
  • Multifunctional polymeric polyurethane prodrug polymer nano diagnosis and treatment agent
  • Multifunctional polymeric polyurethane prodrug polymer nano diagnosis and treatment agent

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Experimental program
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Effect test

Embodiment 1

[0040] experiment

[0041] Cisplatin was purchased from Shandong Boyuan Pharmaceutical Co., Ltd. (Jinan, Shandong, China). Poly(ethylene glycol) monomethyl ether (mPEG5k-OHMn=5000 g / mol) was purchased from Sigma-Aldrich. Hexamethylene diisocyanate (HDI), dibutyltin dilaurate and L-lysine diisocyanate (LDI) were purchased from Aladdin Reagent Company (Shanghai, China). Medium (DMEM), phosphate buffered saline (PBS) and trypsin were purchased from GE Healthcare Life Sciences. Fetal bovine serum (FBS) was purchased from Thermo Fisher Scientific Inc. (Shanghai, China). Unless otherwise stated, all chemical reagents were of analytical grade without further purification. Dichloromethane (DCM), dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF) were dissolved in calcium 2 ) was dried for 2 weeks before further purification.

[0042] Instrumentation: Nuclear magnetic resonance (NMR) spectra were recorded on a Bruker AVANCE II 400 NMR spectrometer at room temperature (RT). ...

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Abstract

The invention belongs to the field of medicines, and provides a functional polymerization type polyurethane prodrug polymer nano diagnosis and treatment agent, PUCPt is prepared from cyanine dye, cis, cis, trans-[Pt (NH3) 2Cl2 (OH) 2], lysine diisocyanate and polyethylene glycol monomethyl ether derivatives as raw materials. The main chain type platinum (IV) and cyanine dye (HOCyOH) multifunctional polymeric polyurethane prodrug polymer PUCPt provided by the invention is of an amphiphilic structure, can be self-assembled into nano particles in an aqueous solution, has relatively high drug loading capacity and drug loading efficiency, and shows effective intracellular uptake and enhanced cell proliferation inhibition effects on cancer cells. PUCPt, PUCPt NPs, or drug delivery systems comprising them are promising platforms for platinum and HOCyOH co-based multimode imaging, photothermal therapy in combination with chemotherapy.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel multifunctional polymeric polyurethane prodrug polymer PUCPt, its nanoparticles, its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Cancer remains one of the most dreaded diseases due to high rates of metastasis, recurrence and mortality. Early diagnosis and treatment are important to control cancer. Recently, theranostics based on combining diagnostic and therapeutic elements into a single nanoplatform has attracted increasing attention. Especially magnetic resonance imaging, near-infrared fluorescence imaging (NIRF), computed tomography ...

Claims

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Application Information

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IPC IPC(8): A61K47/59A61K31/555A61K9/19A61K41/00A61K49/00A61K49/04A61P35/00A61K49/22C08G18/28
CPCA61K31/555A61K47/59C08G18/283A61K41/0042A61K41/0052A61K9/19A61P35/00A61K49/04A61K49/0054A61K49/221A61K49/225A61K49/0485A61K49/0093A61K49/0002A61K2300/00
Inventor 吴延娟刘国正伍家振许本
Owner QILU UNIV OF TECH
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