Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Microfluidic preparation method and application of marine polymer microspheres

A technology of polymer microspheres and polymer solutions, which is applied in the direction of microsphere preparation, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of high price, cumbersome process steps, and complicated preparation. , to achieve the effect of low cost, simple process and easy industrial production

Pending Publication Date: 2022-05-13
XIAMEN UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, auxiliary agents such as emulsifiers and organic crosslinking agents are often toxic and harmful, or the preparation is complicated, or the price is too high
Under the conditions of using these additives, the preparation of chitosan microspheres or alginic acid microspheres by microfluidic method also involves the elution of emulsifiers and unreacted cross-linking agents, the resulting wastewater discharge and residues, etc. , resulting in more cumbersome process steps and higher costs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microfluidic preparation method and application of marine polymer microspheres
  • Microfluidic preparation method and application of marine polymer microspheres
  • Microfluidic preparation method and application of marine polymer microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The chitosan is respectively dissolved in 0.5% aqueous solution of hydrochloric acid, sulfuric acid, nitric acid, acetic acid and formic acid to prepare a solution with a mass concentration of chitosan of 1%. The obtained chitosan solution is used as the internal phase, isobutanol is selected as the external phase, and the isobutanol solution of 1% NaOH is used as the receiving liquid. In the microfluidic system, the above-mentioned chitosan solution was input into a capillary with an outlet diameter of 100 μm through a pressure pump, and its flow rate in the microfluidic system was adjusted to 1 mL / h. The external phase was also input through a pressure pump at a flow rate of 100mL / h; under the shear action of the external phase, the internal phase forms independent spherical micro-droplets, which are carried into the receiving liquid with the external phase. After about 10 minutes, spherical chitosan microspheres can be solidified to obtain spherical chitosan microsphe...

Embodiment 2

[0047] Embodiment 2 (lower limit of chitosan concentration, lower limit of alkali concentration)

[0048] Chitosan was dissolved in 0.5% acetic acid aqueous solution to prepare a chitosan solution with a mass concentration of 0.3%. The obtained chitosan solution was used as the internal phase, isoamyl alcohol was selected as the external phase, and the isobutanol solution of NaOH with a mass concentration of 0.1% was used as the receiving liquid. In the microfluidic system, the above-mentioned chitosan solution was input into a capillary with an outlet diameter of 100 μm through a pressure pump, and its flow rate in the microfluidic system was adjusted to 4 mL / h, and the external phase was also input through a pressure pump with a flow rate of 120 mL. / h; under the shear action of the external phase, the internal phase forms independent spherical micro-droplets, which are carried into the receiving solution with the external phase, and can be solidified to obtain chitosan micr...

Embodiment 3

[0049] Embodiment 3 (mixed acid, flow rate ratio lower limit)

[0050] Prepare 1% acetic acid aqueous solution and 0.5% nitric acid aqueous solution. Mix the two solutions in equal volumes to prepare a mixed acidic solution, and use the mixed solution as a solvent to dissolve chitosan to prepare a solution with a mass concentration of chitosan of 1.0%. The obtained chitosan solution is used as the inner phase, isoamyl alcohol is selected as the outer phase, and the isoamyl alcohol solution of 1.0% NaOH is used as the receiving liquid. In the microfluidic system, the above-mentioned chitosan solution was input into a capillary with an outlet diameter of 100 μm through a pressure pump, and its flow rate in the microfluidic system was adjusted to 4mL / h. The external phase was also input through a pressure pump at a flow rate of 120mL / h; under the shearing action of the external phase, the internal phase forms independent spherical micro-droplets, which are carried into the recei...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Saturated adsorption capacityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a microfluidic preparation method of marine polymer microspheres and application thereof, and the method comprises the following steps: (1) taking a marine polymer solution as an internal phase liquid and an organic solvent as an external phase liquid, simultaneously introducing the internal phase liquid and the external phase liquid into a microfluidic device, and under the strong shearing action of the external phase liquid, carrying out microfluidics reaction on the internal phase liquid and the external phase liquid to obtain the marine polymer microspheres; the internal phase liquid forms independent micro-droplets at the outlet of the capillary tube; and (2) enabling the independent micro-droplets to enter a receiving liquid under the carrying of an external phase liquid, gradually solidifying, separating out and condensing, and curing to obtain the stable marine polymer microspheres. The marine polymer microspheres are prepared by adopting a micro-fluidic method without an emulsifier and an organic cross-linking agent, so that the toxicity and the harmfulness of the emulsifier and the organic cross-linking agent are avoided, and the problems of wastewater discharge, residues and the like caused by tedious elution of the emulsifier and the organic cross-linking agent are also avoided.

Description

technical field [0001] The invention belongs to the technical field of preparation of marine polymer microspheres, and in particular relates to a microfluidic preparation method and application of marine polymer microspheres. Background technique [0002] As an abundant renewable natural polymer resource in nature, chitosan, the deacetylated product of marine polymers such as chitin, is the only alkaline polysaccharide in nature, which has good biocompatibility, biodegradability and antibacterial properties, and has Hemostasis and promote wound healing. [0003] There are a large number of randomly arranged amino groups in the chitosan molecular chain, which can be protonated and dissolved in acidic medium, so that chitosan fibers, chitosan membranes, chitosan hydrogels, and shells can be prepared from chitosan solutions. Polycan airgel, chitosan microspheres and other new materials. Among them, chitosan microsphere material has the advantages of high specific surface area...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01J13/02B01J20/24B01J20/28B01J20/30A61K47/36A61K9/16A61K31/513A61P35/00
CPCB01J13/02B01J20/24B01J20/22B01J20/06B01J20/103B01J20/20B01J20/28021A61K47/36A61K9/1652A61K31/513A61P35/00B01J2220/4806B01J2220/4812B01J2220/4825
Inventor 熊晓鹏钟成堂黄晨曦余兆菊
Owner XIAMEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com