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Compound preparation containing levofloxacin and cimetidine and preparation method

A technology of levofloxacin and cimetidine, which is applied in the field of medicine, can solve the problems of poor effects on anaerobic bacteria and enterococci, large side effects, and unsatisfactory curative effect of levofloxacin, and achieve good infection effects, low side effects, and good application prospects Effect

Pending Publication Date: 2022-05-20
崔天佑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gram-negative for most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Haemophilus influenzae, Legionella pneumophila, Neisseria gonorrhoeae, etc. Bacteria have strong antibacterial activity; it also has antibacterial effect on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Mycoplasma pneumoniae and Chlamydia pneumoniae, and has poor effect on anaerobic bacteria and enterococci
During the long-term clinical use, it was found that levofloxacin alone cannot achieve satisfactory curative effect, and the side effects are large

Method used

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  • Compound preparation containing levofloxacin and cimetidine and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A compound preparation comprising levofloxacin and cimetidine, in the active ingredients of the compound preparation, the weight ratio of levofloxacin and cimetidine is 0.1:0.1, and the balance is auxiliary materials. Its preparation method comprises the following steps:

[0022] (1) take by weighing levofloxacin 20g, cimetidine 20g, standby;

[0023] (2) Take an appropriate amount of required auxiliary materials suitable for the prepared preparation, and set aside;

[0024] (3) Tablets are made according to the pharmaceutical tablet preparation method, so that each tablet contains 200 mg of levofloxacin and 200 mg of cimetidine.

Embodiment 2

[0026] A compound preparation comprising levofloxacin and cimetidine, in the active ingredients of the compound preparation, the weight ratio of levofloxacin and cimetidine is 0.4:0.3, and the balance is auxiliary materials. Its preparation method comprises the following steps:

[0027] (1) take by weighing levofloxacin 40g, cimetidine 30g, standby;

[0028] (2) Take an appropriate amount of required auxiliary materials suitable for the prepared preparation, and set aside;

[0029] (3) Capsules are made according to the pharmaceutical capsule preparation method, so that each capsule contains 200 mg of levofloxacin and 150 mg of cimetidine.

Embodiment 3

[0031] A compound preparation comprising levofloxacin and cimetidine, in the active ingredients of the compound preparation, the weight ratio of levofloxacin and cimetidine is 0.5:0.4, and the balance is auxiliary materials. Its preparation method comprises the following steps:

[0032] (1) take by weighing levofloxacin 50g, cimetidine 40g, standby;

[0033] (2) Take an appropriate amount of required auxiliary materials suitable for the prepared preparation, and set aside;

[0034] (3) Make dispersible tablets according to the preparation method of pharmaceutics dispersible tablets, so that each tablet contains 500 mg of levofloxacin and 400 mg of cimetidine.

[0035] drug efficacy test

[0036] 1. Treatment of respiratory diseases

[0037] 1. Select the medicines prepared in Examples 1, 2, and 3 for clinical trials.

[0038] According to the design plan of parallel, randomized and controlled experiments, a control group is strictly set up to observe the clinical curative ...

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Abstract

The invention provides a compound preparation containing levofloxacin and cimetidine and a preparation method of the compound preparation. The active ingredients of the pharmaceutical composition comprise levofloxacin and cimetidine in a ratio of (0.1-0.5): (0.05-0.4). The raw material medicines in corresponding parts are taken, and proper auxiliary materials are added according to a corresponding preparation preparation method of pharmaceutics, so that the raw material medicines can be respectively prepared into dosage forms such as tablets, capsules and injections. In the application, the levofloxacin reduces the duplication of bacterial DNA by inhibiting the activity of bacterial DNA gyrase, and causes bacterial apoptosis, thereby achieving the antibacterial effect. Cimetidine is a liver drug enzyme inhibitor and can delay metabolism of the combined drug and improve the blood concentration of the combined drug so as to improve the curative effect of the combined drug. The two medicines are prepared into a compound preparation, infection caused by sensitive bacteria is treated, the antibacterial effect is enhanced, side effects are reduced, and the compound preparation is safe to take and convenient to take and has a good application effect.

Description

technical field [0001] The application relates to the field of medical technology, in particular to a compound preparation comprising levofloxacin and cimetidine and a preparation method thereof. Background technique [0002] Levofloxacin belongs to quinolones, which has broad-spectrum antibacterial effect and strong antibacterial effect. Gram-negative for most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Haemophilus influenzae, Legionella pneumophila, Neisseria gonorrhoeae, etc. Bacteria have strong antibacterial activity; Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and Mycoplasma pneumoniae, Chlamydia pneumoniae also have antibacterial effect, and the effect on anaerobic bacteria and enterococcus is poor. During the long-term clinical use, it was found that levofloxacin alone cannot achieve satisfactory curative effect and has serious side effects. Therefore, i...

Claims

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Application Information

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IPC IPC(8): A61K31/5383A61K31/4164A61P31/04
CPCA61K31/5383A61K31/4164A61P31/04A61K2300/00
Inventor 崔天佑
Owner 崔天佑
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