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Preparation method of nanoprobe for nuclide imaging and multi-mode combined treatment

A combined therapy and nanoprobe technology, which is applied in the field of nuclide imaging and multimodal combined therapy nanoprobe preparation, can solve the problems of single, unfavorable wide application of nanomaterials, single therapeutic or imaging nuclides, etc.

Pending Publication Date: 2022-05-24
SHANXI MEDICAL UNIV
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Problems solved by technology

[0006] Although there are many studies on the loading of polydopamine nanomaterials with anti-tumor drugs and nuclides, most of them still stay on a single nanocarrier label, a single therapeutic or imaging nuclide, which is not conducive to the application of nanomaterials in biomedicine. widely used

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  • Preparation method of nanoprobe for nuclide imaging and multi-mode combined treatment
  • Preparation method of nanoprobe for nuclide imaging and multi-mode combined treatment

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[0053] In order to understand the above objects, features and advantages of the present invention more clearly, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be noted that the embodiments of the present application and the features in the embodiments may be combined with each other in the case of no conflict.

[0054] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can also be implemented in other ways different from the description herein. Therefore, the protection scope of the present invention is not limited by the specific embodiments disclosed below. limits.

[0055] Some embodiments in accordance with the present invention provide first synthesis of PDA-PEG-IX.

[0056] 90mL of ultrapure water was added to a 150mL round-bottomed flask, heated to 50°C in an oil bath,...

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Abstract

The invention relates to the technical field of nano biological probes, in particular to a preparation method of a nano probe for nuclide imaging and multi-mode combined treatment. A water phase oxidation method is adopted to synthesize polydopamine nano-particles with uniform size, and the surfaces of the polydopamine nano-particles are modified with a layer of polyethylene glycol (PEG) and loaded with IX through a Michael addition reaction and a condensation reaction respectively. Nuclides 131I, 99mTc and 177Lu are labeled on PDA through a chloramine-T method, a stannous chloride (SnCl2) reduction method and a DOTA chelation method respectively, the labeling yield and stability are detected, and the obtained nuclide-loaded probe is applied to breast cancer diagnosis and combined treatment. Research results show that the PDA nanoparticles have a good photo-thermal effect, and controllable photo-thermal therapy is achieved by adjusting laser power and probe concentration.

Description

technical field [0001] The invention relates to the technical field of nanobiological probes, and more specifically, relates to a preparation method of nanoprobes for nuclide imaging and multimodal combined therapy. Background technique [0002] Cancer has the characteristics of high morbidity and high mortality, which has caused serious harm to human health. At present, traditional CT / MRI imaging technology, tissue biopsy and other detection methods are mainly used in the diagnosis and treatment of cancer, as well as chemotherapy, radiotherapy and surgery. Resection is the main treatment method. However, the complex mechanism of tumorigenesis, difficulty in early diagnosis and easy recurrence make the treatment effect unsatisfactory. With the advent of precision medicine, tumor-targeted multimodal imaging and treatment have brought great improvements to the accurate diagnosis and precise treatment of tumors. Among them, positron emission computed tomography (PET / CT) and si...

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Application Information

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IPC IPC(8): A61K51/04A61K51/06A61K51/12A61K41/00A61P35/00A61K103/10A61K101/02A61K103/30
CPCA61K51/06A61K51/0482A61K51/1244A61K41/0052A61K41/0033A61P35/00Y02P20/55
Inventor 安杰李亚渊贺鑫怡菅少洁陈耀东武志芳李思进
Owner SHANXI MEDICAL UNIV
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