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Anti-inflammatory water-in-oil-in-water emulsion and application thereof

A water-based emulsion and oil-in-water technology, which is applied in anti-inflammatory agents, cosmetic preparations, medical preparations containing active ingredients, etc., can solve the problem of inability to simultaneously coat water-based ingredients and oil-based ingredients, and water-in-oil systems. Greasy and uncomfortable, low skin transmission efficiency and other problems, to achieve good anti-inflammatory function, good emulsification effect, and remarkable effect

Active Publication Date: 2022-05-27
山东福瑞达生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] A single oil-in-water / water-in-oil system cannot cover both water-based ingredients and oil-based ingredients at the same time; moreover, the water-in-oil system feels greasy and uncomfortable to use, rigid cells are not easy to deform, and the skin transmission efficiency is low, which will make the distribution outside ingredients lose their activity prematurely

Method used

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  • Anti-inflammatory water-in-oil-in-water emulsion and application thereof
  • Anti-inflammatory water-in-oil-in-water emulsion and application thereof
  • Anti-inflammatory water-in-oil-in-water emulsion and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0053] Preparation of 1,8-cineole used in this example:

[0054] 1) rectifying the crude oil of camphor oil containing 48-55% of 1,8-cineole, the pressure is -90Kpa, and taking 75-83 ℃ of distillation sections;

[0055] 2) Ethylene glycol and acetonitrile were evenly mixed at a volume ratio of 8:2, and then 200 g of the above-mentioned fractions were mixed with 600 g of a mixed solvent of ethylene glycol and acetonitrile at 25°C for 2 hours, and allowed to stand for 2 hours;

[0056] 3) 600 g of water was added to the supernatant and stirred for 2 hours, and after standing for 2 hours, the lower layer was put down to obtain 1,8-cineole with a content of 99% (w / W).

[0057] Preparation of Tanshinone:

[0058] 1) Take the dried Salvia miltiorrhiza, soak it, clean the sediment and salt on the surface, then air-dry it, pulverize it, pass it through a 200-mesh sieve, and sterilize it by cobalt 60 irradiation with an irradiation intensity of 7500-8500kGy;

[0059] 2) Soak the powd...

Embodiment 1

[0061] Embodiment 1: proportioning (weight part):

[0062] Oil phase: 2.5 parts of EM90 water-in-oil emulsifier, 4 parts of dioctyl carbonate, 8 parts of polydimethylsiloxane, 2 parts of squalane, 2 parts of tanshinone, 1 part of 1,8-cineole, total 19.5 copies;

[0063] Inner water phase: 8 parts of glycerol, 4 parts of butanediol, 68.5 parts of purified water of inner water phase, a total of 80.5 parts;

[0064] External water phase: 0.15 part of carbomer, 0.2 part of polyacrylate cross-linked polymer-6, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1,2-hexanediol, 0.12 part of tromethamine, external water phase 98.53 parts of purified water.

[0065] Preparation method of emulsion:

[0066] S1: oil phase preparation: add EM90 water-in-oil emulsifier to the oil phase (dioctyl carbonate, polydimethylsiloxane, squalane, tanshinone, 1,8-cineole), slowly at 200r / min Stir for 10 minutes until a homogeneous liquid is formed, 19.5 parts in total;

[0067] S2: preparation of in...

Embodiment 2

[0071] Embodiment 2: proportioning (weight part):

[0072] Oil phase: 4 parts of EM90 water-in-oil emulsifier, 4 parts of dioctyl carbonate, 8 parts of polydimethylsiloxane, 2 parts of isononyl isononanoate, 2 parts of squalane, 2 parts of tanshinone, 1, 1 part of 8-cineole, a total of 23 parts;

[0073] Inner water phase: 8 parts of glycerol, 3 parts of dipropylene glycol, 66 parts of inner water phase purified water, a total of 77 parts;

[0074] External water phase: 0.15 part of carbomer, 0.2 part of sodium polyacrylate, 0.8 part of octanoyl hydroxamic acid, 0.15 part of triethanolamine, and 98.70 parts of purified water of external water phase.

[0075] Preparation method of emulsion:

[0076] S1: Formulation of the oil phase: EM90 water-in-oil emulsifier was added to the oil phase (dioctyl carbonate, dimethicone, squalane, isononyl isononanoate, tanshinone, 1,8-eucalyptus 10 minutes at 250 r / min until 23 parts of uniform liquid are formed;

[0077] S2: Preparation of...

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Abstract

The invention discloses an anti-inflammatory water-in-oil-in-water emulsion and application thereof. According to the invention, 1, 8-cineole and tanshinone are taken as main effective components to prepare the anti-inflammatory oil-in-water-in-oil-in-water emulsion, so that skin penetration of active substances is promoted, and a better skin care effect is achieved. Experiments prove that the water-in-oil-in-water emulsion has a relatively strong anti-inflammatory function on the skin, can inhibit the generation of free radicals, has a relatively good anti-photoaging function, can inhibit the expression of inflammatory factors, and remarkably improves the facial redness condition, so that the water-in-oil-in-water emulsion has a good application prospect in the field of skin anti-inflammatory.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to an anti-inflammatory water-in-oil-in-water emulsion and an application thereof. Background technique [0002] As the largest organ of the human body, the skin is the first barrier to protect the body from external stress. Chemical substances in external stress and UV irradiation can stimulate the skin to produce inflammatory factors tumor necrosis factor-α (TNF-α) and interleukin-1α (IL-1α). TNF-α leads to the up-regulation of epithelial cell adhesion molecules, IL -1α stimulates mast cells to cause vasodilation and increased permeability, manifested as leakage of white blood cells and red blood cells, proliferation of capillaries and lymphatic vessels, and accompanied by obstruction of lymphatic return, resulting in the production of skin inflammation, which is manifested in the body as itching , redness, dandruff and other inflammatory reactions. In addition, excessive infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/63A61K8/49A61K8/86A61K8/06A61Q19/08A61P29/00
CPCA61K8/345A61K8/63A61K8/4973A61K8/86A61K8/066A61Q19/08A61P29/00A61K2800/78A61K2800/592
Inventor 郭芳钰韩婷婷杨素珍王兴凯陈玉荣王晓梅王晓娜郭海姣
Owner 山东福瑞达生物股份有限公司
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