Intravascular stent as well as preparation method and application thereof

A technology of vascular stents and thrombin inhibitors, which is applied in the field of vascular stents and its preparation, can solve the problems of excessive release rate, failure of anticoagulant coating, and thrombus hazards, so as to inhibit the formation of thrombus, increase the release time, and improve The effect of slow release effect

Active Publication Date: 2022-06-07
DONGGUAN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Among them, the inorganic thin film coating has better anticoagulant function, but its flexibility is poor, and it is easy to fall off during the process of stent pressing, pushing and expansion, causing thrombus to cause harm; drug blended organic coating can effectively maintain the activity of anticoagulant molecules, but release Too fast rate leads to rapid failure of anticoagulant coating; chemical coupling and fixed anticoagulant molecules can effectively improve the utilization rate and chemical stability of anticoagulant molecules, but will affect the activity of anticoagulant molecules to a certain extent; electrostatic self-assembly fixed anticoagulant Anticoagulant molecules can also be immobilized on the surface of anticoagulant molecules, which can retain the activity of anticoagulant molecules to a greater extent, but the chemical stability and environmental stability of anticoagulant molecules immobilized by chemical coupling strategies are poorer

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  • Intravascular stent as well as preparation method and application thereof
  • Intravascular stent as well as preparation method and application thereof
  • Intravascular stent as well as preparation method and application thereof

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preparation example Construction

[0031] In a first aspect, the present invention provides a method for preparing a vascular stent, comprising sequentially depositing nitric oxide on the surface of the vascular stent to catalyze the release of micro-nano particles and a thrombin inhibitor, and modifying the surface of the vascular stent. Wherein, the nitric oxide catalyzed release micro-nano particles include a compound skeleton and a compound having a nitric oxide catalytic release function doped in the compound skeleton, and the compound skeleton includes one of a phenolic compound, a quinone compound and a ketone compound or more. The thrombin inhibitor is deposited by adsorption by means of immobilization.

[0032] In the treatment of some vascular repair products or cardiovascular diseases, the use of vascular stents has become the main method. However, in the actual use of vascular stents, there is still damage to the vascular tissue at the lesion site caused by stent expansion, which further leads to th...

Embodiment 1

[0078] This embodiment provides a blood vessel stent, which includes selenium-containing nitric oxide synthesized by adsorbing tannic acid and selenocystamine on the surface of a 316L SS blood vessel stent to catalyze the release of micro-nano particles, and redeposit the bivalirudin thrombin inhibitor. The preparation steps are as follows:

[0079] S1. Preparation of Nitric Oxide Catalytic Release Micro-nano Particles

[0080] The tannic acid was weighed and dissolved in PBS buffer with pH 8 to prepare tannic acid solution A with a concentration of 1 mg / mL.

[0081]The selenocystamine molecule containing selenium was weighed and dispersed in a PBS buffer with a pH of 8 to prepare a selenocystamine solution B with a concentration of 0.1 mg / mL.

[0082] The copper chloride containing copper ions was weighed and dispersed in a PBS buffer with a pH of 8 to prepare a copper chloride solution C with a concentration of 0.1 mg / mL.

[0083] Mix solution A, solution B and solution C ...

Embodiment 2

[0089] This embodiment provides a blood vessel stent, which comprises the catalyzed release of micro-nano particles by adsorbing tannic acid, selenocystamine and copper chloride on the surface of a 316L SS blood vessel stent, and copper ion-doped nitric oxide, and redepositing bivalir. A thrombin inhibitor, the preparation steps of which are as follows:

[0090] S1. Preparation of Nitric Oxide Catalytic Release Micro-nano Particles

[0091] The tannic acid was weighed and dissolved in PBS buffer with pH 8 to prepare tannic acid solution A with a concentration of 1 mg / mL.

[0092] The selenocystamine molecule containing selenium was weighed and dispersed in a PBS buffer with a pH of 8 to prepare a selenocystamine solution B with a concentration of 0.1 mg / mL.

[0093] Weigh cupric chloride and disperse it in PBS buffer with pH 8 to prepare cupric chloride solution C with a concentration of 0.01 mg / mL.

[0094] Mix solution A, solution B and solution C according to the substanc...

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Abstract

The invention discloses an intravascular stent and a preparation method and application thereof, and relates to the technical field of biomedical material preparation. According to the intravascular stent, nitric oxide catalytic release micro-nano particles and a thrombin inhibitor are sequentially deposited on the surface of the intravascular stent, and the surface of the intravascular stent is modified. The nitric oxide catalytic release micro-nano particles are stable in chemical structure under the conditions of room temperature and normal pressure, nitric oxide catalytically released by the nitric oxide catalytic release micro-nano particles can inhibit activation and adhesion of platelets, and meanwhile active reaction functional groups on the surfaces of the nitric oxide catalytic release micro-nano particles can be grafted or grafted; therefore, fixation of nitric oxide catalytic release micro-nano particles on the surface of the stent and effective loading and controllable elution of drugs on the surfaces of the micro-nano particles are realized, and the slow release effect is improved. In addition, the thrombin inhibitor is fixed in an adsorption manner, so that the elution time of the thrombin inhibitor can be prolonged, and controllable elution of the thrombin inhibitor is realized.

Description

technical field [0001] The present invention relates to the technical field of biomedical material preparation, in particular to a vascular stent and a preparation method and application thereof. Background technique [0002] At present, metal-based vascular stents have developed into the main means of cardiovascular disease treatment. Stent expansion can cause damage to the vascular tissue at the lesion site, resulting in the formation of thrombus, which seriously endangers the health of the patient, and even endangers the safety of life. At present, the strategies to solve this problem mainly include drug treatment and stent surface modification. [0003] Among them, drug treatment mainly includes injection of anticoagulants, oral anticoagulants, use of platelet antagonists and use of thrombolytic drugs, etc. However, the use of drugs is accompanied by the risk of side effects such as bleeding, drug resistance and gastrointestinal reactions. [0004] The surface modifica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/22A61L27/50A61L27/54A61L33/00A61L33/12
CPCA61L27/28A61L27/50A61L27/54A61L27/227A61L33/128A61L33/0094A61L2300/21A61L2300/204A61L2300/42A61L2300/622A61L2300/252
Inventor 杨志禄王文轩牟小辉杜泽煜王颖张文泰
Owner DONGGUAN PEOPLES HOSPITAL
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