Pharmaceutical composition for removing acnes and preparation method thereof
A composition and medicine technology, applied in the field of skin care, can solve the problems of low patient acceptance, increased skin light sensitivity, long treatment time, etc., and achieve the effects of simple and convenient preparation method, inhibiting pain and itching, and highlighting the treatment effect.
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[0025] The application also provides a preparation method of a medicinal composition for removing acne, comprising the following steps:
[0026] After mixing amoxicillin, morpholineguanidine, ketoconazole, clobetasol propionate, lincomycin and lidocaine, place in a non-metallic mortar, grind to obtain a mixture, and store it in the dark;
[0027] The adjuvant and the transdermal agent are mixed with the mixture, water is added and stirred, and the finished pharmaceutical composition is obtained after heating and stirring evenly.
[0028] The preparation method of the present application is simple and convenient, and can prepare the pharmaceutical composition in batches.
[0029] In some embodiments of the present application, the above-mentioned grinding time is 3-8 min. After sufficient crushing, it can facilitate the uniform distribution of the medicine.
[0030] In some embodiments of the present application, the above heating is specifically heating at 60-80° C. for 30-5...
Embodiment 1
[0033] A preparation method of a medicinal composition for removing acne, comprising the following steps:
[0034] Raw materials: amoxicillin 3g, morpholineguanidine 2g, ketoconazole 50mg, clobetasol propionate 5mg, lincomycin 90mg, lidocaine 50mg and transdermal agent (mint oil) 500mg.
[0035] After mixing amoxicillin, morpholineguanidine, ketoconazole, clobetasol propionate, lincomycin and lidocaine, place them in a non-metallic mortar and grind for 3 minutes to obtain a mixture, which is protected from light;
[0036] The transdermal agent (mint oil) was mixed with the mixture, water was added and stirred, heated at 60° C. for 30 min, and after stirring evenly, the finished pharmaceutical composition was obtained.
Embodiment 2
[0038] A preparation method of a medicinal composition for removing acne, comprising the following steps:
[0039]Raw materials: amoxicillin 4g, morpholine guanidine 2.5g, ketoconazole 60mg, clobetasol propionate 2.5mg, lincomycin 65mg, lidocaine 50mg, transdermal agent (clove oil) 400mg and excipients (glycerol ) 10g.
[0040] After mixing amoxicillin, morpholineguanidine, ketoconazole, clobetasol propionate, lincomycin and lidocaine, place in a non-metallic mortar and grind for 3 minutes to obtain a mixture, which is stored in the dark;
[0041] The adjuvant (glycerol) and the transdermal agent (clove oil) are mixed with the mixture, water is added and stirred, heated at 60° C. for 30 minutes, and after stirring uniformly, the finished pharmaceutical composition is obtained.
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