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Preparation and application of nano gold shell particles with near-infrared two-region absorption

A technology of nano-gold and gold nano-shells, applied in the field of materials, can solve the problems of inability to effectively control the kinetic parameters of shell growth, cumbersome synthesis methods, uneven thickness of gold shell layers, etc. The effect of high heat conversion efficiency and uniform size

Pending Publication Date: 2022-06-24
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been many methods for growing gold shells using silicon, metal-organic frameworks, and other nanomaterials (such as cobalt, silver, and iron oxide) as templates, but these synthetic methods are cumbersome and cannot effectively control the growth kinetic parameters of the shells. , leading to random and disordered growth of the gold shell, resulting in uneven thickness of the gold shell and lack of regularity and integrity of the appearance. Therefore, the constructed gold shell is usually located in the NIR-I absorption window, which greatly limits its photothermal Clinical Applications in Oncology and Imaging
However, it is a great challenge to develop nano-gold shell particles with absorption in the second near-infrared region. Such nanomaterials with excellent absorption in the second region of the infrared have not been reported yet.

Method used

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  • Preparation and application of nano gold shell particles with near-infrared two-region absorption
  • Preparation and application of nano gold shell particles with near-infrared two-region absorption
  • Preparation and application of nano gold shell particles with near-infrared two-region absorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation of nano-gold shell particles in this example is as follows:

[0056] 1) Preparation of UiO-66-NH 2 : Soak the water and heat pipe used in the reaction in an alkali tank overnight, brush it clean and rinse it with ethanol three times, and finally put it in an oven to dry for use. ZrCl 4 (42mg) and NH 2 -BDC (33 mg) was added to 32 mL of DMF solution followed by 0.1 mL of deionized water. Then 1.7 mL of acetic acid solution was added, sonicated for 30 min, and the reacted solution was transferred to an autoclave at 120 °C for crystallization for 2 h. After cooling to room temperature, the precipitate was recovered, washed with DMF and ethanol by centrifugation at 8260 rpm for 3 times, and dispersed in 30 mL of ethanol. medium spare.

[0057] 2) Preparation of UGs: take 7mL K 2 CO 3 (1.10mg / mL) in the reaction tube, then add 0.32mL HAuCl 4 (10 mg / mL) aqueous solution for aging reaction, vigorously stirred (1000 rpm) in the dark for 15 min, and then p...

Embodiment 2

[0059] The preparation of nano-gold shell particles in this example is as follows:

[0060] 1) Preparation of UiO-66-NH 2 : Soak the water and heat pipe used in the reaction in an alkali tank overnight, brush it clean and rinse it with ethanol three times, and finally put it in an oven to dry for use. ZrCl 4 (40mg) and NH 2 -BDC (30 mg) was added to 25 mL of DMF solution followed by 0.1 mL of deionized water. Then 1.4 mL of acetic acid solution was added, sonicated for 30 min, and the reacted solution was transferred to an autoclave at 120 °C for crystallization for 2 h. After cooling to room temperature, the precipitate was recovered, washed with DMF and ethanol at 8260 rpm for 3 times, and dispersed in 25 mL of ethanol. medium spare.

[0061] 2) Preparation of UGs: take 6 mL of K 2 CO 3 (1.0mg / mL) in the reaction tube, then add 0.1mL HAuCl 4 (5.0 mg / mL) aqueous solution for aging reaction, vigorously stirred (1000 rpm) in the dark for 20 min, and then placed in a dark...

Embodiment 3

[0063] The preparation of nano-gold shell particles in this example is as follows:

[0064] 1) Preparation of UiO-66-NH 2 : Soak the water and heat pipe used in the reaction in an alkali tank overnight, brush it clean and rinse it with ethanol three times, and finally put it in an oven to dry for use. ZrCl 4 (44mg) and NH 2 -BDC (34 mg) was added to 40 mL of DMF solution followed by 0.15 mL of deionized water. Then add 1.5 mL of acetic acid solution, sonicate for 30 min, transfer the reacted solution into an autoclave at 120 ° C for crystallization for 2 h, and after cooling to room temperature, recover the precipitate, wash three times with DMF and ethanol at 8260 rpm, and disperse in 30 mL of ethanol medium spare.

[0065] 2) Preparation of UGs: take 10 mL of K 2 CO 3 (1.15mg / mL) in the reaction tube, then add 0.3mL HAuCl 4 (15 mg / mL) aqueous solution for aging reaction, vigorously stirred (1000 rpm) in the dark for 5 min, and then placed in a dark place for later use...

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Abstract

The invention discloses a preparation method and application of a nano gold shell particle with near-infrared two-region absorption. The inner core of the nano gold shell particle comprises UiO-66-NH2; and the shell layer of the nano gold shell particle is a gold nano shell. The nano gold shell particle disclosed by the invention is narrow in particle size distribution, and controllable in shell thickness, particle size and infrared second-region absorption peak; the preparation method of the nano gold shell particles is simple and convenient in process, simple to operate, low in equipment requirement, low in cost and easy for large-scale production; the nano gold shell particle has an excellent photo-thermal treatment effect, has the advantages of good biocompatibility, high photo-thermal conversion efficiency and small cytotoxicity, and can be widely applied to photo-thermal treatment, CT imaging or photoacoustic imaging.

Description

technical field [0001] The invention belongs to the field of materials, in particular to the preparation and application of nano-gold shell particles with near-infrared second region absorption. Background technique [0002] Cancer has become an important threat to human life safety today, and cancer treatment has become one of the most difficult problems in the medical field. At present, surgical resection, chemotherapy and radiotherapy are the main methods of clinical treatment of tumors, but surgical resection of tumors may cause tumor metastasis; current radiotherapy and chemotherapy drugs do not have good selectivity, and are likely to cause systemic or local toxic side effects. At the same time, photothermal therapy based on nanomaterials and nanotechnology has attracted extensive attention. Photothermal materials can convert near-infrared light into thermal effects, which can improve the treatment efficiency without side effects, which has spawned a new "nanomedicine"...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/16A61K49/00A61K49/04A61K49/22A61P35/00B22F1/18B22F1/054B22F1/07B22F9/24B82Y5/00B82Y15/00B82Y40/00
CPCA61K41/0052A61K9/167A61P35/00A61K49/0002A61K49/0423A61K49/0419A61K49/225B22F9/24B82Y5/00B82Y15/00B82Y40/00
Inventor 陈金香陈明孟维陈晓彤张莲英
Owner SOUTHERN MEDICAL UNIVERSITY
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