Application of recombinant human hyaluronidase preparation

A technology of human hyaluronidase and hyaluronic acid, which is applied in the application field of recombinant human hyaluronidase preparations, can solve the problems of ineffective treatment, low risk of allergy, poor curative effect, etc., and achieves high concentration of active protein and effective treatment. Good results
CN114681594APending Publication Date: 2022-07-01SHANGHAI BAO PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI BAO PHARM CO LTD
Publication Date
2022-07-01

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Abstract

The invention discloses an application of a recombinant human hyaluronidase preparation. The recombinant human hyaluronidase preparation is prepared from recombinant human hyaluronidase, a buffering agent, a stabilizing agent and a nonionic surfactant, wherein the enzyme activity of the recombinant human hyaluronidase is 45 to 450,000 units / ml; the concentration of the buffering agent is 5-50 mM; the concentration of the stabilizer is 1-500mM, and the stabilizer is selected from one or more of trehalose, cane sugar, mannitol, sodium chloride and methionine; the concentration of the nonionic surfactant is 0.01%-0.1% (w / v); the pH value of the recombinant human hyaluronidase preparation is 5.0 to 8.0. The problems that when an existing clinically-used hyaluronidase extraction product is used for treating, correcting or preventing side reactions such as vascular embolism, excessive filling or uneven filling caused by hyaluronic acid filling, the intravenous administration dosage is too large, the effect is poor, and subcutaneous local treatment is poor in safety and curative effect can be solved.
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Description

technical field

[0001] The invention belongs to the field of corrective treatment in plastic surgery and beauty, in particular to the application of a recombinant human hyaluronidase preparation. Background technique

[0002] Hyaluronic acid (HA), also known as uronic acid, hyaluronic acid or hyaluronic acid, is a linear polymer glycosaminoglycan composed of two disaccharide units, D-glucuronic acid and N-acetylglucosamine, which are repeatedly connected. Glycans are widely present in the connective tissue, mucous tissue, lens of the eyeball and skin of vertebrates, especially in embryos, cartilage, synovial fluid, vitreous body, umbilical cord, cockscomb and other tissues. Hyaluronic acid is the most widely distributed acidic mucopolysaccharide in human tissue matrix. It has various functions in the body, such as forming a variety of matrices, limiting the diffusion of water and other extracellular substances, regulating osmotic pressure, and regulating macromolecular subst...

Claims

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