Bifidobacterium bifidum capable of reducing fat, relieving hyperglycemia and regulating intestinal immunity and application of bifidobacterium bifidum
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A technology of Bifidobacterium bifidum and strains, applied in the field of microorganisms, can solve the problems of limited efficacy, poor viability of probiotics, unsatisfactory effects, etc., and achieve good tolerance, lower blood sugar, and improve insulin resistance index effects
Active Publication Date: 2022-07-01
河北一然生物科技股份有限公司
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Problems solved by technology
However, the current probiotics have technical defects such as poor viability, unsatisfactory effect, and limited efficacy. Therefore, finding a probiotic with high viability and multiple functions has gradually become a hot topic in this field.
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Embodiment 1
[0058] Isolation, purification and identification of strains
[0059] 1.1 Isolation and purification of strains
[0060] Take fresh fecal samples from healthy infants, put them in a sterile container, add normal saline to fully dilute and mix, and dilute 10-fold gradient, take the diluted samples and spread them in modified MRS medium (plus mupirocin lithium salt), 37 Anaerobic culture at ℃ for 48h; observe the colony morphology, pick single colonies of different shapes and culture them in liquid modified MRS medium at 37℃ for 17-24h; dip the cultured bacterial liquid with an inoculation loop, and streak on the modified MRS medium, Anaerobic culture at 37°C for 48h; observe the colony morphology and by Gram staining, select Gram-positive rod-shaped or bifurcated strains, repeat the single colony picking and streaking steps to obtain pure strains.
[0061] 1.2 Identification of strains
[0062] Physiological and biochemical characteristics and 16SrDNA identification of the ob...
Embodiment 2
[0073] This embodiment provides a powder containing Bifidobacterium bifidum B11.
[0074] Mix 10% of Bifidobacterium bifidum B11 freeze-dried powder, 20% of isomaltose oligosaccharide, 10% of chitosan oligosaccharide, 15% of dietary fiber, 7.5% of fruit and vegetable powder and 37.5% of lactitol by mass percentage, and formulate according to the number of viable bacteria. Product specification and packaging, the powder product containing Bifidobacterium bifidum B11 is obtained.
Embodiment 3
[0076] This example provides a granule containing Bifidobacterium bifidum B11.
[0077] Mix Bifidobacterium bifidum B11 freeze-dried powder, isomalt, starch, sweetener, essence and nutritional fortifier, and granulate by conventional methods. Granules containing Bifidobacterium bifidum B11 were obtained.
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Abstract
The invention relates to the technical field of microorganisms, in particular to bifidobacterium bifidum capable of reducing fat, relieving hyperglycemia and regulating intestinal immunity and application of the bifidobacterium bifidum. The preservation number of the bifidobacterium bifidum B11 is CGMCC (China General Microbiological Culture Collection Center) No.24381. The strain has good tolerance to gastric acid environment and bile salt and can effectively improve glucose and lipid metabolism disorder phenomena induced by obesity and the like, and viable thalli, inactivated thalli or metabolites of the bifidobacterium bifidum B11 have the capacity of improving constipation or repairing intestinal mucosal barriers, so that the bifidobacterium bifidum B11 can be used for preparing the oral preparation for treating constipation. Meanwhile, the organism immunity can be remarkably improved by viable thalli or inactivated thalli.
Description
technical field [0001] The invention relates to the technical field of microorganisms, in particular to a bifidobacteria bifidum capable of reducing fat, relieving hyperglycemia, and regulating intestinal immunity and its application. Background technique [0002] With the change of human life style, bad living habits such as high sugar / fat diet, alcoholism, sedentary and staying up late have made diseases such as type II diabetes, obesity, non-alcoholic fatty liver disease mainly characterized by disorder of glucose and lipid metabolism. The high incidence rate has become one of the most important health problems of modern people. In addition, changes in bad living habits and dietary structure are also accompanied by an increase in the incidence of constipation year by year. Years of constipation can lead to hemorrhoids, anal fissures, and proctitis. In severe cases, it can induce heart and brain diseases. Constipation can also accumulate toxins in the body, affect the fun...
Claims
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