Method for establishing quantitative fingerprint spectrum of standard fructus evodiae decoction

A fingerprint and Evodia technology, which is applied in the field of establishing the quantitative fingerprint of Evodia standard decoction, can solve the problems of providing reference for the quality control of difficult Evodia formula granules, unable to meet the quality control requirements of Evodia, analysis time and efficiency constraints, etc., and achieve stability. and good reproducibility, easy realization of chromatographic conditions, and reduction of detection costs.
CN114705779APending Publication Date: 2022-07-05赣江中药创新中心
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
赣江中药创新中心
Publication Date
2022-07-05

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Abstract

The invention discloses a method for establishing a quantitative fingerprint spectrum of a fructus evodiae standard decoction, and relates to the field of establishment of fingerprint spectrums.The method comprises the following steps that 1, a reference substance solution is prepared; (2) preparing a test solution; (3) carrying out ultra-high performance liquid chromatography analysis; and (4) establishing a quantitative fingerprint, introducing multiple batches of liquid chromatograms into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system, matching common peaks, generating a control characteristic spectrum, selecting reference peaks, calculating the relative retention time of each characteristic peak, and determining the content of three components, namely limonin, evodiamine and rutaecarpin. And establishing a quantitative fingerprint spectrum of the fructus evodiae standard decoction. According to the method, the characteristic chromatogram and the content of the fructus evodiae standard decoction can be detected at the same time through one-time analysis, the detection time can be effectively shortened, the working efficiency is improved, and a guarantee is provided for quality and consistency evaluation of fructus evodiae formula granules.
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Description

technical field

[0001] The invention relates to the field of establishment of fingerprints, in particular to a method for establishing quantitative fingerprints of Evodia Fructus standard decoction. Background technique

[0002] Evodia is Rutaceae Euodia rutaecarpa (Juss.) Benth., Shihu E.rutaecarpa (Juss.) Benth.var.officinalis (Dode) Huang or Evodia rutaecarpa (Juss.) Benth.var.bodinieri ( The dried and near-ripe fruit of Dode) Huang has the functions of dispelling cold and relieving pain, reducing inversion and relieving vomiting, and helping yang and relieving diarrhea. Acid, five more diarrhea and so on. Modern studies have shown that Evodia mainly contains alkaloids, bitter substances, volatile oils and flavonoids, among which evodial and evodial are the main active components. Modern pharmacological studies have shown that it has analgesic, anti-inflammatory, anti-ulcer, antibacterial, anti-tumor and protective effects on the cardiovascular system [Liu Li. Chinese H...

Claims

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