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Calcium alginate-ichthite patch for treating surgical local infection

A calcium alginate, local infection technology, applied in the medical field, can solve problems such as restricting the clinical application of surgical external medicine, failing to meet clinical treatment needs, reducing drug bioavailability, etc., so as to improve bioavailability, avoid drug spillover, and give The effect of skin adhesion

Pending Publication Date: 2022-07-08
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main preparation is ichthyol ointment. However, when the drug is applied to the skin, the bioavailability of the drug is reduced due to the barrier effect of the stratum corneum and the short skin adhesion time.
Ichthyote ointment has disadvantages such as low bioavailability, unsuitable control of drug dose, easy to stain clothes, small viscosity, easy to fall off, easy to dry and harden, etc., and cannot meet clinical needs
The shortcomings of traditional dosage forms and the lag in research and development of dosage forms restrict the clinical application of external surgical drugs, which cannot meet the needs of clinical treatment, so the innovation of dosage forms is very important

Method used

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  • Calcium alginate-ichthite patch for treating surgical local infection
  • Calcium alginate-ichthite patch for treating surgical local infection
  • Calcium alginate-ichthite patch for treating surgical local infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] refer to Figure 1-4 , a calcium alginate-fish stone paste for treating surgical local infection, comprising the following raw materials: sodium alginate, fish stone fat, calcium chloride and deionized water; comprising the following specific preparation steps:

[0033] S1: Configure solution A: Dissolve a certain amount of sodium alginate in deionized water to form a sodium alginate solution with a certain concentration, fully dissolve the air in the liquid, and let it stand for a certain period of time to obtain solution A, and then add solution A into the needle;

[0034] S2: The first injection into the mold: inject solution A into the PDMS mold, do not fill it up, leave a certain height, and empty the air;

[0035] S3: Configure solution B: dissolve a certain amount of calcium chloride in deionized water to form a calcium ion solution with a certain concentration, which is solution B, and then put solution B into the needle tube;

[0036] S4: The second injection...

Embodiment 2

[0051] refer to Figure 1-4 , a calcium alginate paste for treating surgical local infection, comprising the following raw materials: sodium alginate, fish oil, calcium chloride and deionized water; comprising the following specific preparation steps:

[0052] S1: Configuration solution A: Dissolve a certain amount of sodium alginate in deionized water to form a sodium alginate solution with a certain concentration, and then dissolve a certain amount of ichthyol in the sodium alginate solution, fully dissolve and discharge the air in the liquid, And let stand for a certain period of time to obtain solution A, and then put solution A into the needle;

[0053] S2: The first injection into the mold: inject solution A into the PDMS mold, do not fill it up, leave a certain height, and empty the air;

[0054] S3: Configure solution B: Dissolve a certain amount of calcium chloride and ichthyol in deionized water to form a calcium ion-ichthyol solution of a certain concentration, whi...

Embodiment 3

[0070] refer to Figure 1-4 , a calcium alginate paste for treating surgical local infection, comprising the following raw materials: sodium alginate, fish oil, calcium chloride and deionized water; comprising the following specific preparation steps:

[0071] S1: Configuration solution A: Dissolve a certain amount of sodium alginate in deionized water to form a sodium alginate solution with a certain concentration, and then dissolve a certain amount of ichthyol in the sodium alginate solution, fully dissolve and discharge the air in the liquid, And let stand for a certain period of time to obtain solution A, and then put solution A into the needle;

[0072] S2: The first injection into the mold: inject solution A into the PDMS mold, do not fill it up, leave a certain height, and empty the air;

[0073] S3: Configure solution B: Dissolve a certain amount of calcium chloride and ichthyol in deionized water to form a calcium ion-ichthyol solution of a certain concentration, whi...

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Abstract

The invention discloses a calcium alginate-ichthin patch for treating surgical local infection, and belongs to the technical field of medical treatment, and the calcium alginate-ichthin patch is prepared by the following preparation steps: S1, dissolving sodium alginate to obtain a solution A; s2, injecting the solution A into a PDMS mold; s3, dissolving calcium chloride to form a solution B; s4, injecting the solution B into a mold, and cross-linking for a certain time to obtain a calcium alginate film; s5, preparing a ichthrite solution, namely a solution C; s6, soaking the film in deionized water to remove redundant calcium ions, and then soaking the film in the solution C to obtain a calcium alginate-ichthite film; s7, freezing and drying the thin film to obtain the calcium alginate-ichthite patch; s8, screening out defective products; s9, disinfection and sterilization; and S10, packaging and warehousing finished products. The gel has the advantages of high bioavailability, quick and lasting efficacy, good moisture retention, large drug loading capacity, good air permeability, convenience and comfort in use, no irritation and sensitization to skin, no pollution to clothes, convenience in cleaning and the like.

Description

technical field [0001] The invention relates to the technical field of medical treatment, in particular to a calcium alginate-ichthyol paste for treating surgical local infection. Background technique [0002] There are many chronic and difficult-to-heal wounds in clinical practice, such as pressure ulcers, bedsores, diabetic foot, etc. These wounds require a long treatment time, and the disease is easy to repeat, which not only brings great pain to patients, but also brings a heavy economic burden. Traditional external medicine plus dressing change is dry dressing, which has wound dehydration, scabbing, unfavorable epithelial cell crawling, loss of bioactive substances, slow healing speed, patient pain, dressing and wound adhesion, and mechanical damage when dressing is changed again. and other disadvantages. [0003] Most external medicines of traditional Chinese medicine have special colors and smells. For example, Zhenjiang dogpi ointment is a black oily ointment, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/04
CPCA61K35/04A61K31/734A61K9/7007A61K47/36A61P17/00A61P17/02A61P7/04A61P31/04A61K2300/00Y02A50/30
Inventor 李日成潘海邦王波刘美王天明
Owner GANSU UNIV OF CHINESE MEDICINE
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