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Collagen oligopeptide and extraction process thereof

A collagen extraction technology, applied in the direction of animal/human protein, specific peptide, connective tissue peptide, etc., can solve the problems of high molecular weight of collagen oligopeptide, insufficient collagen decomposition, low hydrolysis rate, etc., to achieve effective Facilitate digestion and absorption, reduce average molecular weight, and improve quality

Active Publication Date: 2022-07-12
河北昊鹿翔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, enzymatic methods are mostly used to produce collagen, but the decomposition of collagen in the prior art is insufficient, the hydrolysis rate is low, and the molecular weight of the obtained collagen oligopeptide is relatively high

Method used

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  • Collagen oligopeptide and extraction process thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1-3

[0039] A kind of adjusting solvent of preparation example 1-3, its each raw material and each raw material consumption are as shown in table 1, and its preparation method is as follows:

[0040] Each raw material is weighed according to the amount in Table 1, and then mixed evenly to adjust the solvent.

[0041] Each raw material and each raw material consumption (kg) of table 1 preparation example 1-3

[0042] Preparation Example 1 Preparation Example 2 Preparation Example 3 isopropyl alcohol 3 4 6 Ethanol 15 13 10 Diacetin 4 5 7

preparation example 4

[0044] A kind of adjusting solvent, the difference from Preparation Example 2 is that its raw material also includes 0.5kg of triethyl citrate, and the remaining steps are the same as those of Preparation Example 2.

preparation example 5

[0046] A kind of adjusting solvent, the difference from Preparation Example 2 is that its raw material also includes 1.0kg of triethyl citrate, and the remaining steps are the same as those of Preparation Example 2.

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Abstract

The invention relates to the technical field of collagen oligopeptides, and relates to a collagen oligopeptide and an extraction process thereof, the extraction process comprises the following steps: S1, cleaning; s2, chopping and homogenizing animal skin, adding water, and then adjusting the pH value through a hydrochloric acid solution and sodium hydroxide to obtain slurry; s3, adding compound protease into the slurry for enzymolysis, and heating for inactivation to obtain a mixed solution A; s4, adding activated carbon into the mixed solution A for decoloration, and performing solid-liquid separation to obtain a clear solution; s5, dropwise adding an adjusting solvent into the clear liquid to obtain a precipitate B and a solution B; s6, inorganic ions in the solution B are removed, concentration and drying are performed, and a first product is obtained; s7, drying the precipitate B obtained in the step S5, dissolving the precipitate B in water, repeating the step S3 to obtain a solution C, and concentrating and drying the solution C to obtain a second product; and S8, mixing the first product and the second product to obtain the collagen oligopeptide. The method has the advantage of reducing the molecular weight of the oligopeptide after enzymolysis of the animal skin collagen.

Description

technical field [0001] The present application relates to the technical field of collagen oligopeptides, in particular to a collagen oligopeptide and an extraction process thereof. Background technique [0002] Collagen oligopeptide is a molecular polymer after the biodegradation of collagen, which is formed by connecting two or more amino acids through peptide bonds. Collagen is widely used in medicine, health food, cosmetics and other fields, and its demand is also increasing year by year. [0003] The existing collagen oligopeptides are mainly prepared by two methods: artificial synthesis and collagenase hydrolysis. However, the technical requirements and costs of artificial synthesis are relatively high, chemical reagents are likely to remain, and the degree of marketization is low. The collagenase hydrolysis method has stable activity and strong biocompatibility, its safety is higher, and the reaction process is easier to control, so it is more widely used. [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/78C12P21/06
CPCC07K14/78C12P21/06Y02P20/10
Inventor 陈昊董贺翔孙宗册
Owner 河北昊鹿翔生物科技有限公司
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