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Mesoporous silicon drug loading system, preparation method and mesoporous silicon loaded drug

A technology of mesoporous silicon and mesoporous silica, which is applied in the fields of pharmaceutical formulations, radioactive carriers, antineoplastic drugs, etc., can solve the problems of short loading time and difficulty in triggering the release of carriers, and achieves small drug impact, rapid assembly, Biocompatibility Biodegradable Effects

Active Publication Date: 2022-07-22
INST OF MACHINERY MFG TECH CHINA ACAD OF ENG PHYSICS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, researchers have been developing new nanocarriers, however, the design of carriers with short loading time and triggered release is still a difficult problem

Method used

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  • Mesoporous silicon drug loading system, preparation method and mesoporous silicon loaded drug
  • Mesoporous silicon drug loading system, preparation method and mesoporous silicon loaded drug
  • Mesoporous silicon drug loading system, preparation method and mesoporous silicon loaded drug

Examples

Experimental program
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Effect test

Embodiment 1

[0043] The mesoporous silicon drug loading system uses mesoporous silica as the carrier, the surface of the mesoporous silica is connected to cinnamaldehyde after surface amination treatment, and the gold nanoparticles coated with β-cyclodextrin are used as the mesoporous Silica pore blocking agent.

[0044] The mesoporous silicon drug-loading system described in this embodiment can be used to load drugs, including antitumor drugs (such as doxorubicin, pirarubicin hydrochloride, etc.), PET contrast agents (such as deoxyglucose-based contrast agents) 18 F-FDG, nitroimidazole hypoxic contrast agents 18 F-FMISO, etc.) and β-lactoglobulin, which can be used for multimodal imaging and targeted therapy of tumors, etc.

Embodiment 2

[0046] This embodiment is described with the loaded drug as doxorubicin (so the drug in this example is limited to doxorubicin):

[0047] A mesoporous silicon drug-carrying system comprises the mesoporous silicon drug-carrying system as described in Embodiment 1, wherein the mesoporous silicon drug-carrying system is loaded with a drug, and the drug comprises doxorubicin.

[0048] like figure 1 , figure 2 As shown, the specific preparation process of the mesoporous silicon drug loading described in this embodiment is as follows:

[0049] (1) Synthesis of Mesoporous Silicon Nanospheres (MSNS)

[0050] Take 32ml of cetyltrimethylammonium chloride / water solution with a mass fraction of 25%, add 88ml of deionized water, and then add 1.44ml of triethanolamine / water solution with a mass fraction of 25%, heat in an oil bath at 60 °C, as water Mutually. 40 ml of a 20% volume fraction of tetraethyl silicate / cyclohexane solution was freshly prepared and added to the water phase to ...

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Abstract

The invention discloses a meso-porous silicon drug loading system, a preparation method thereof, a meso-porous silicon drug and the meso-porous silicon drug loading system, meso-porous silicon dioxide is used as a carrier, the surface of the meso-porous silicon dioxide is subjected to surface amination treatment and then is connected with cinnamyl aldehyde, and gold nanoparticles coated with beta-cyclodextrin are used as a pore blocking agent of the meso-porous silicon dioxide. According to the invention, the construction of the carrier is completed through rapid assembly under the supramolecular host-guest effect between cyclodextrin and cinnamyl aldehyde; when the drug loading system encounters an acid environment, imine is triggered to break, the gold particles leave the mesoporous silica, and the drug is released; meanwhile, the whole system is non-toxic, high in biocompatibility and biodegradable before and after carrier construction and disintegration, that is, mesoporous silicon drug loading can quickly construct a drug loading carrier and can respond to trigger to release the drug in an acid environment, the drug can be quickly delivered to a specific part, the possibility is provided for targeted delivery of the drug with short drug effect time, and the application prospect is broad. Wide application prospects are realized.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a mesoporous silicon drug-carrying system, a preparation method and a mesoporous silicon drug-carrying system. Background technique [0002] Response-triggered-release drug carrier is a carrier for targeted drug delivery that changes the structure or chemical properties of the carrier by triggering a response to a stimulus after delivering the drug to a specific site. . There are a variety of stimuli used to trigger the release of drugs in response to the different types of stimuli, which can be divided into exogenous stimuli such as temperature, light, ultrasound, magnetic field, and endogenous stimuli such as pH, redox, and enzyme catalysis. [0003] The early diagnosis of tumors, cardiovascular diseases and neurological diseases has important clinical significance for the prediction and treatment of the disease. At present, clinical PET-CT (positron emission tomo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/69A61K45/00A61K31/704A61P35/00A61K51/02A61K51/06A61K101/02
CPCA61K47/02A61K47/6951A61K47/6929A61K45/00A61K31/704A61P35/00A61K51/02A61K51/06Y02A50/30
Inventor 董会陆骊工代毅潘金龙黄姝珂占美晓
Owner INST OF MACHINERY MFG TECH CHINA ACAD OF ENG PHYSICS