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Molecularly imprinted mixed ligand lanthanide trimetal-organic framework and preparation method thereof

A mixed ligand and molecular imprinting technology, which is applied in the direction of material excitation analysis, fluorescence/phosphorescence, etc., can solve the problems of low detection limit and insufficient sensitivity, and achieve the effects of low detection limit, simple preparation method and low cost

Pending Publication Date: 2022-07-22
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, when Ln-MOFs are used in sensing, there are insufficient sensitivity and low detection limit.

Method used

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  • Molecularly imprinted mixed ligand lanthanide trimetal-organic framework and preparation method thereof
  • Molecularly imprinted mixed ligand lanthanide trimetal-organic framework and preparation method thereof
  • Molecularly imprinted mixed ligand lanthanide trimetal-organic framework and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation method of molecularly imprinted mixed ligand lanthanide trimetal-organic framework (one-pot method)

[0023] 1) 450 mg of gadolinium nitrate hexahydrate Gd (NO 3 ) 3 ·6H 2 O, 3mg europium nitrate hexahydrate Eu (NO 3 ) 3 ·6H 2 O, 0.1mL0.3g / L terbium nitrate hexahydrate Tb(NO 3 ) 3 ·6H 2 O, 254mg 1,2,4,5-benzenetetracarboxylic acid (H 4 BETC), 180 mg of 2,5-furandicarboxylic acid (H 2 FDA), 5 mL methanol and 40 mL water were added to a 100 mL round bottom flask, and refluxed at 95°C for 4 hours;

[0024] 2) Filter and wash the obtained white powder with water and methanol, and air dry naturally.

Embodiment 2

[0026] Preparation of crystalline materials (step-by-step method):

[0027] 1) 450 mg of gadolinium nitrate hexahydrate Gd (NO 3 ) 3 ·6H 2 O, 3mg europium nitrate hexahydrate Eu (NO 3 ) 3 ·6H 2 O, 0.1mL0.3g / L terbium nitrate hexahydrate Tb(NO 3 ) 3 ·6H 2 O, 254mg 1,2,4,5-benzenetetracarboxylic acid (H 4 BETC), 180 mg of 2,5-furandicarboxylic acid (H 2 FDA) was dissolved in a mixed solvent of 15 mL of N,N-dimethylformamide and 25 mL of water, 8 mL of the above solution was added to a 20 mL vial, and reacted at 95°C for 5 hours to obtain a transparent strip-shaped mixed ligand lanthanide Crystals of trimetal-organic framework (NKU-66-EuGdTb);

[0028] 2) Put 460 mg of NKU-66-EuGdTb crystals into methanol at 50 °C for 72 hours and exchange them repeatedly to obtain a molecularly imprinted mixed ligand lanthanide trimetal-organic framework (NKU-66-EuGdTb-P) with template removal. crystals;

[0029] 3) Wash the obtained crystals with water and air dry naturally.

Embodiment 3

[0031] Characterization:

[0032] Get the crystal (NKU-66-EuGdTb) obtained in the above-mentioned embodiment 2 on the glass slide, select the suitable crystal under the microscope, carry out the test on the XtaLAB Mini II type X-ray single crystal diffractometer, use the graphite monochromatic Monochromated Mo-Kα rays is the incident radiation source, with The diffraction points were collected by scanning, their coordinates and their anisotropy parameters were corrected by the least square method, and the positions of hydrogen atoms were obtained by theoretical hydrogenation. All calculations were performed using the SHELXTL package. The crystal structure was analyzed by Olex-2 software, combined with the results of elemental analysis, inductively coupled plasma resonance and thermogravimetric analysis, the molecular formula of NKU-66-EuGdTb-P powder was finally determined as {[Eu 0.0067 Gd 0.992 Tb 0.0013 (BETC) 0.5 (FDA) 0.5 (H 2 O) 2 ]·0.25CH 3 OH 2H 2 O} n , w...

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Abstract

The invention discloses a molecular imprinting mixed ligand lanthanide series trimetal-organic framework and a preparation method thereof, the molecular imprinting mixed ligand lanthanide series trimetal-organic framework is called NKU-66-EuGdTb-P for short, the chemical formula of the molecular imprinting mixed ligand lanthanide series trimetal-organic framework is {[Eu < 0.0067 > Gd < 0.992 > Tb < 0.0013 > (BETC) < 0.5 > (FDA) < 0.5 > (H2O) < 2 >]. 0.25 CH3OH. 2H2O} n, and in the formula, n is a positive integer which is at least 1; bETC is 1, 2, 4, 5-benzene tetracarboxylic acid radical; and FDA is 2, 5-furandicarboxylic acid radical. The preparation method of the molecularly imprinted mixed ligand lanthanide series trimetal-organic framework is simple, pollution-free and low in cost, and the molecularly imprinted mixed ligand lanthanide series trimetal-organic framework can be used for rapidly and sensitively detecting an unstable senile disease marker-pyruvic aldehyde; the material has low detection limit on the pyruvic aldehyde and covers the physiological plasma concentration of the pyruvic aldehyde of a human body.

Description

technical field [0001] The invention belongs to the field of preparation of detection materials, and particularly relates to a preparation method of fluorescent detection materials and uses thereof. Background technique [0002] As the population ages, age-related diseases become extremely common, which requires the development of fast and easy diagnostic methods to predict the generation of pathological tissue, and then further detect the disease through imaging methods for early diagnosis and treatment. The purpose of disease, thereby improving the survival rate and quality of life of the elderly after the disease. As a reactive carbonyl molecule associated with metabolic activity, pyruval has been extensively studied and reported as a universal biomarker for various age-related diseases such as diabetes, vascular complications, and cancer. However, glyoxal is reactive, and its detection is easily affected by redox species, so it is necessary to realize its rapid detectio...

Claims

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Application Information

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IPC IPC(8): C08G83/00G01N21/64
CPCC08G83/008G01N21/6428G01N2021/6443Y02A50/30
Inventor 师唯闵辉程鹏
Owner NANKAI UNIV
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