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Sustained-release gel as well as preparation method and application thereof

A slow-release gel and gelatin technology, applied in anti-inflammatory agents, pharmaceutical formulations, aerosol delivery, etc., can solve the problem of short drug onset concentration time, poor skin biocompatibility, poor drug release performance, etc. problems, to achieve the effect of not easily causing allergies, beneficial to drug efficacy, and good sustained-release function

Pending Publication Date: 2022-07-29
江苏莹华生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, for ordinary gels, the drug dissolution rate is generally too fast, the drug onset concentration time is relatively short, the drug release performance is poor, which affects the drug effect, or the biocompatibility with the skin is not good, and the drug loading capacity is small.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A new gel, comprising the following components by mass percentage:

[0028] Carbomer 980 4%; Gum Arabic 5%; Gelatin 3.1%; Silkworm Protein Microspheres 3.1%; Povidone K30 1.5%; Macrogol 400 4%; Glycerin 20%; Sodium Hydroxide 1.5%; Ethylparaben 0.05%; 2 parts of silicon dioxide powder; Azone 1.4%; Water 60%.

[0029] The materials in the above proportions are mixed and stirred, and the desired gelling agent is obtained after drying. Carbomer 980 is a polyacrylic acid cross-linked polymer that forms high viscosity gels at very low concentrations. It has good thickening performance, high transparency, high viscosity, strong suspension ability, excellent suspension stability and swelling. The gel has good suspending performance, sufficient viscosity of the gel, easy and uniform mixing of medicinal components, and good release performance, which is beneficial to the exertion of medicinal effects. The gel is a hydrophilic matrix with a large drug loading, especially suitab...

Embodiment 2

[0031] Take Carbomer 980 400g; Gum Arabic 500g; Gelatin 300g; Silk Protein Microspheres 300g; Povidone K30150g; Polyethylene Glycol 400 400g; 200 copies; Azone 120g; Water 6000g. The materials in the above proportions are mixed and stirred, and the desired gelling agent is obtained after drying.

Embodiment 3

[0033] The present invention also provides a kind of preparation method of preparing above-mentioned new gel, comprises the following steps:

[0034] (1) get 5g of ethyl paraben and add it to 10000mL of water, be heated to 80 DEG C to dissolve the ethyl paraben, make an aqueous solution of ethyl paraben, and let it cool for later use;

[0035] (2) Add 2000g glycerol and 400g polyethylene glycol 400 to 1000mL of ethyl paraben aqueous solution and mix evenly, then add 400g carbomer 980 and 500g gum arabic mixture and stir evenly, then add 300g gelatin, 150g polyvitamin to the mixed solution A mixture of ketone K30 and 2000 mL of an aqueous solution of ethyl paraben, stirred evenly, placed overnight, stirred and reacted at 50 to 60 ° C for 1 hour to prepare a mixed matrix for later use;

[0036] (3) 120g of sodium hydroxide was added to 1000mL of ethyl hydroxyphenate aqueous solution, stirred to dissolve the sodium hydroxide, then the above solution was added to the mixed matrix ...

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PUM

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Abstract

The invention belongs to the field of medicines, and relates to a sustained-release gel which comprises the following components in parts by mass: 3-4 parts of carbomer 980; 4-5 parts of Arabic gum; 2.75 to 3.1 parts of gelatin; 2.75 to 3.1 parts of silkworm color protein microspheres; 1.2 to 2 parts of povidone K30; 3 to 4.2 parts of polyethylene glycol 400; 18 to 22 parts of glycerol; 1-1.5 parts of sodium hydroxide; 0.04 to 0.05 part of ethylparaben; 1.5-2 parts of silicon dioxide powder; 1.2 to 1.4 parts of azone; and 55-65 parts of water. The gel provided by the invention has the advantages of good suspension performance, strong gel viscosity, easy and uniform mixing of medicinal components, and slow release function, and is beneficial to exertion of drug effects. The preparation method of the gel can be used for preparing the gel with the advantages.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a sustained-release gel, a preparation method thereof, and an application of the gel. Background technique [0002] Gels are used in many ointments, such as ointments for the treatment of osteoarthritis, rheumatoid arthritis, osteoarthritis, frozen shoulder and other diseases. Other medicinal ingredients are mixed into gels to form ointments, which are convenient for patients to use. . [0003] However, for common gels, the drug dissolution rate is generally too fast, the drug onset concentration time is relatively short, the drug release performance is poor, which affects the performance of the drug effect, or the biocompatibility with the skin is not good, and the drug load is small. SUMMARY OF THE INVENTION [0004] In order to solve the above technical problems, the present invention provides a sustained-release gel, which has a large drug loading and has a sustained-release effect o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/02A61K47/04A61K47/10A61K47/22A61K47/32A61K47/36A61K47/42A61P19/02A61P19/08A61P29/00
CPCA61K9/06A61K47/32A61K47/42A61K47/10A61K47/02A61K47/22A61K47/36A61P19/02A61P29/00A61P19/08
Inventor 李子强许海玉徐刚
Owner 江苏莹华生物制药有限公司
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