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Application of maggot extract in preparation of medicine for treating digestive diseases and medicine composition

A technology for digestive diseases and grain worms, which is applied in the direction of drug combination, digestive system, medical raw materials derived from arthropods, etc., can solve problems such as inability to treat digestive diseases, achieve clear drug effects and maintain functional integrity

Pending Publication Date: 2022-07-29
NORTHWESTERN POLYTECHNICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention patent with the patent publication number CN 110279720 A claims to protect a processed grain worm product and its application in regulating intestinal flora. Made into grain worm meal to regulate intestinal flora, but only for digestive diseases caused by exogenous pathogenic microorganisms, not for the treatment of digestive diseases caused by opportunistic pathogenic bacteria or viruses

Method used

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  • Application of maggot extract in preparation of medicine for treating digestive diseases and medicine composition
  • Application of maggot extract in preparation of medicine for treating digestive diseases and medicine composition
  • Application of maggot extract in preparation of medicine for treating digestive diseases and medicine composition

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The present embodiment provides the application of the grain worm extract in the preparation of a medicine for treating digestive diseases.

[0030] Compared with the chemical drugs, antibiotics and antiviral drugs currently used in the clinical treatment of peptic ulcer, stress gastroenteritis, bacterial enteritis, viral enteritis and other digestive diseases, the grain worm extract has less toxic and side effects and is not good. Less response.

Embodiment 2

[0032] On the basis of Example 1, this example provides the application of grain worm extract for preparing medicine for treating digestive diseases, and the grain worm extract is grain worm protein extract and / or grain worm amino acid extract, wherein, The mass fraction of total protein in the grain worm protein extract is 35-90%, and the mass fraction of total amino acids in the grain worm amino acid extract is 40-95%.

[0033] The peptic disease is peptic ulcer, stress gastroenteritis, bacterial enteritis or viral enteritis.

[0034] The preparation process of grain worm protein extract is as follows:

[0035] Put sterile five-grain larvae (5 g) into a mortar, add about 3 mL of liquid nitrogen, and grind them sufficiently, and then add 5 mL of an aqueous solution containing 0.1 μg / ml aprotinin and 0.1% trifluoroacetic acid, and grind them thoroughly. The homogenate was ice-bathed in the dark for 60 min, then centrifuged (20000r / min, 4°C, 30min), the supernatant was collect...

Embodiment 3

[0039] This example is to experimentally verify the therapeutic effects of the grain worm protein extract and the grain worm amino acid extract prepared in Example 2 on peptic ulcer.

[0040] 1. Experimental method

[0041] Male Kunming mice (18-22g) were purchased from Beijing Weitong Lihua Co., Ltd. and were randomly divided into normal control group, omeprazole group (2mg / kg), and low-dose group of grain worm protein extract (5mg / kg) , Cereal worm protein extract high-dose group (10mg / kg), Cereal worm amino acid extract low-dose group (5mg / kg), Cereal worm amino acid extract high-dose group (10mg / kg), Cereal worm protein extract + Cereals worm amino acid extract (1:1, 10mg / kg), 8 animals in each group. The drug treatment group was given the corresponding drugs by gavage every day for 7 days. After the administration on the 7th day, the rats were fasted without food and water, and 1 hour after the last administration, they were given aspirin-ethanol solution (200 mg / kg of a...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and digestive system disease treatment, and particularly relates to application of a maggot extract in preparation of a medicine for treating digestive diseases and a pharmaceutical composition. According to the invention, the maggot protein extract and maggot amino acid are used for treating peptic ulcer, irritable bowel syndrome, bacterial enteritis and viral enteritis, and the drug effect is clear, safe and reliable. Wherein the extraction process of the maggot protein extract and the maggot amino acid is not treated by an organic solvent, is free from toxic reagent pollution, is safe and harmless, and belongs to a pure natural preparation; meanwhile, the pharmaceutical composition mainly comprises natural protein and amino acid, has no toxic or side effect and does not generate adverse reaction.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and the treatment of digestive system diseases, in particular to the application and pharmaceutical composition of a grain worm extract for preparing a medicine for the treatment of digestive diseases. Background technique [0002] Cereal worms are the larvae of Clivia sericata, golden fly or other closely related insects. According to the records of Chinese medicine classics such as "Materia Medica for the Original" and "Materia Medica Bian Du", five grain insects are cold in nature, non-toxic, and enter the spleen and stomach meridians. The medicinal value of grain worms has been found for more than 500 years in my country. In terms of surgical treatment, after drying and grinding, it is used for external application and can treat infectious surgical diseases such as eczema, lip furuncle and carbuncle. "Ben Cao Qiuzhen" records "treatment of rottenness". "Chinese Medicine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P1/04A61P1/00A61P31/04A61P31/12
CPCA61K35/64A61P1/04A61P1/00A61P31/04A61P31/12
Inventor 段佳林李峥嵘
Owner NORTHWESTERN POLYTECHNICAL UNIV
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