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Method for preparing glycollic acid and methyl glycolate by hydrolyzing methyl methoxyacetate and methoxyacetic acid

A technology of methyl methoxyacetate and methoxyacetic acid, which is applied in the field of chemical product preparation, and can solve the problems of waste of raw materials and no application of preparation process, etc.

Pending Publication Date: 2022-08-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the prior art, the methylal carbonylation product methyl methoxyacetate is not used in the preparation process of glycolic acid and methyl glycolate
And the use of methoxyacetic acid after the hydrolysis of the ester bond of methyl methoxyacetate is relatively less, resulting in waste of raw materials

Method used

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  • Method for preparing glycollic acid and methyl glycolate by hydrolyzing methyl methoxyacetate and methoxyacetic acid
  • Method for preparing glycollic acid and methyl glycolate by hydrolyzing methyl methoxyacetate and methoxyacetic acid
  • Method for preparing glycollic acid and methyl glycolate by hydrolyzing methyl methoxyacetate and methoxyacetic acid

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Experimental program
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Effect test

Embodiment approach

[0075] According to the problems existing in the existing production technologies of glycolic acid and methyl glycolate, the present invention develops a method for preparing glycolic acid and methyl glycolate by hydrolysis of methoxyacetate and methoxyacetic acid. Moreover, the method of the invention is especially suitable for methylal produced by coal chemical industry, and methyl methoxyacetate is generated through carbonylation reaction, and then glycolic acid and methyl glycolate are prepared by hydrolysis.

[0076] Specifically, the present invention provides a method for preparing glycolic acid and methyl glycolate by hydrolysis of methoxyacetate and methoxyacetic acid. The raw materials methoxyacetate, methoxyacetic acid and water are passed through The reaction zone carrying the catalyst is reacted to produce glycolic acid and methyl glycolate under certain reaction conditions;

[0077] The catalyst is any one or a mixture of a solid acid catalyst, a liquid acid cata...

Embodiment 1

[0118] Select the acid H-ZSM-5 molecular sieve with Si / Al=20 purchased from the Catalyst Factory of Zhongke Catalysis New Technology (Dalian) Co., Ltd., crush and sieve it into 0.4-0.8mm particles, take 2g Into a stainless steel reaction tube with an inner diameter of 8mm, activate it with 50mL / min nitrogen at 500°C for 4h, and react under the following conditions: reaction temperature (T)=160°C, reaction pressure (P)=0.1MPa, raw material molar ratio (methoxyl Methyl acetate + methoxyacetic acid) / water = 1:6; molar ratio (methyl methoxyacetate / methoxyacetic acid) = 5:1; the mass of raw material methyl methoxyacetate and methoxyacetic acid Airspeed (WHSV)=0.6h -1 . After 24 hours of reaction, the product was analyzed by gas chromatography and liquid chromatography. The reaction results based on carbon number are shown in Table 1. Among them, the negative ion mass spectrometry results of glycolic acid in the product analyzed by liquid chromatography-mass spectrometry are as fo...

Embodiment 2-8

[0120] The catalysts, reaction conditions and reaction results are shown in Table 1. Other operations are the same as in Example 1.

[0121] Catalytic reaction results in Table 1 Examples 1-8

[0122]

[0123]

[0124]

[0125] It can be seen from Table 1 that the acidic molecular sieves show good catalytic performance in the reaction of methyl methoxyacetate and methoxyacetic acid to hydrolyze glycolic acid and methyl glycolate, and the target product selectivity is high.

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Abstract

The invention discloses a method for preparing glycollic acid and methyl glycolate through hydrolysis of methyl methoxyacetate and methoxyacetic acid. The method comprises the following steps: contacting and reacting a raw material containing methyl methoxyacetate, methoxyacetic acid and water with a catalyst to obtain glycollic acid and methyl glycolate, the catalyst is selected from at least one of a solid acid catalyst, a liquid acid catalyst, a solid base catalyst and a liquid base catalyst. The glycollic acid and methyl glycolate production method can be realized by using a traditional fixed bed reactor, a kettle reactor or a catalytic rectification reactor under normal pressure, and is very suitable for continuous production. The method provided by the invention is combined with a reaction for preparing methylal through condensation of methanol and formaldehyde and a reaction for preparing methyl methoxyacetate through carbonylation of methylal, so that the coal chemical platform substance methanol can be efficiently, green and economically converted into glycollic acid and methyl glycolate.

Description

technical field [0001] The application relates to a method for preparing glycolic acid and methyl glycolate by hydrolysis of methyl methoxyacetate and methoxyacetic acid, and belongs to the technical field of chemical product preparation. Background technique [0002] Glycolic acid, also known as hydroxyacetic acid, is the simplest α-hydroxycarboxylic acid compound. Methyl glycolate can not only be hydrogenated to produce ethylene glycol, but also easily hydrolyzed to produce glycolic acid under mild conditions. Because the molecular structure of glycolic acid contains both hydroxyl and carboxyl groups, it can polymerize itself to form polyglycolic acid (PGA). Polyglycolic acid not only has good biocompatibility, but also has safe biodegradability. Therefore, it is not only widely used in medical surgical sutures, drug release materials, degradable human tissue scaffolds, etc., but also can produce commonly used plastic products. Nowadays, conventional non-degradable plas...

Claims

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Application Information

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IPC IPC(8): C07C67/31C07C69/675C07C51/09C07C51/367C07C59/06
CPCC07C67/31C07C51/09C07C51/367C07C69/675C07C59/06Y02P20/584
Inventor 倪友明朱文良刘中民
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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