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Adsorbent based on montmorillonite for purifying blood and its preparing method

A technology of blood purification and montmorillonite, which is applied in chemical instruments and methods, blood circulation treatment, and other chemical processes, can solve problems such as poor adsorption selectivity, poor blood compatibility, and hemodynamic instability, and achieve good Blood compatibility, the effect of safe use

Inactive Publication Date: 2004-10-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used adsorbents are mainly activated carbon and various resins. To varying degrees, there are problems such as poor adsorption selectivity, poor blood compatibility, and unstable hemodynamics during the adsorption process, which are far from meeting the clinical needs of hemoperfusion. Research and development of highly efficient, highly selective adsorbents that can realize the miniaturization and differentiation of perfusion devices is an important topic in the field of blood purification

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) Weigh 1Kg of the separated and purified calcium-based montmorillonite, add 9 liters of water, and stir evenly to make a suspension. Add 150g NaCl, stir evenly (about 20 minutes) and heat to about 60°C, ion exchange reaction for six hours, stirring from time to time. Then centrifuge to settle, pour off the supernatant, add 9 liters of water, stir evenly, continue to centrifuge, pour off the supernatant. Repeat 3 to 4 times, dehydrate again, dry at 80°C, grind to less than 300 mesh, and obtain sodium-based montmorillonite powder.

[0034] 2) Add 40 g of chitosan and 40 g of gelatin to 1 liter of distilled water, heat and stir in a water bath at 60° C. until completely dissolved.

[0035] 3) Weigh 300g of sodium-based montmorillonite powder, add it into the chitosan and gelatin solution, stir evenly, and keep the temperature in a water bath at 60° C. for 3 hours, stirring from time to time.

[0036] 4) Add a pre-prepared NaOH solution with a concentration of 1% into t...

Embodiment 2

[0039] 1) Add 40 g of chitosan and 40 g of agar in 1 liter of distilled water, heat and stir in a water bath at 50° C. until completely dissolved.

[0040] 2) Weigh 300 g of separated and purified sodium-based montmorillonite powder, add it to the chitosan and agar solution, stir evenly, and keep the temperature in a water bath at 50° C. for 3 hours, stirring from time to time.

[0041] 3) Add pre-prepared sodium tripolyphosphate solution with a concentration of 1% into the container, and spray the suspension of sodium montmorillonite, chitosan and agar into the container while stirring.

[0042] 4) After continuing to stir gently for 20 minutes, centrifuge or filter to separate, wash with water until neutral, steam sterilize, dry at 80°C, and pack.

Embodiment 3

[0044] 1) Add 40 g of chitosan and 40 g of agar in 1 liter of distilled water, heat and stir in a water bath at 50° C. until completely dissolved.

[0045] 2) Weigh 300 g of separated and purified sodium-based montmorillonite powder, add it into the chitosan and agarose solution, stir evenly, and keep the temperature in a water bath at 50° C. for 3 hours, stirring from time to time.

[0046] 3) Add a pre-prepared sodium sulfate solution with a concentration of 1.5% into the container, and spray the suspension of sodium montmorillonite, chitosan and agarose into the container while stirring.

[0047] 4) After continuing to stir gently for 30 minutes, centrifuge or filter to separate, wash with water until neutral, steam sterilize, dry at 80°C, and pack.

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Abstract

An adsorbent based on montmorillonite for purifying blood is a microsoftgel is prepared from purified montmorillonite, chitosan and gelatin through proportional mixing, spraying it in cold coagulating liquid, separation, water washing, sterilizing and baking. Its advantages are high biologic affinity, compability to blood and high adsorption power to toxin.

Description

technical field [0001] The invention relates to a blood purification adsorbent and a preparation method thereof. Background technique [0002] Blood Purification (Blood Purification) is a new technology developed rapidly with the development of biomedical engineering materials, cell molecular biology and its industry. As one of the important components of blood purification, Hemoperfusion (HP) indications Extensive, low cost, can quickly promote the recovery of the disease and save the lives of patients. With the improvement of the types and properties of adsorbents, the clinical application is becoming more and more extensive, from the general use in the treatment of acute and severe drug poisoning, to the treatment of acute and chronic liver failure (artificial liver), acute and chronic renal failure (artificial kidney), Thyroid storm, schizophrenia, systemic lupus erythematosus, psoriasis, sepsis, etc. [0003] Hemoperfusion is an important par...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/38B01J20/02B01J20/32
Inventor 叶瑛王璞夏枚生沈忠悦
Owner ZHEJIANG UNIV