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Veal-blood protein-removed extract infusion and its preparation process

A preparation process, calf blood technology, applied in the directions of drug delivery, peptide/protein composition, drug combination, etc., can solve the problems of increasing the workload of medical staff, increasing the incidence of adverse reactions, increasing clinical allergic reactions, etc., and achieving clinical drug use Safety, reducing the incidence of allergic reactions, and promoting the effect of intake and utilization

Active Publication Date: 2006-04-19
江卫世
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Calf blood deproteinized extract solution is mainly composed of amino acids, small peptides and other nitrogen-containing compounds. Amino acids and small peptides can be polymerized with each other to form large molecular weight peptides in a natural state, and peptides can be polymerized into high molecular weight peptides. Precipitation in the form of polymers or existing in the solution in the form of high-molecular peptides makes the drug produce antigenicity and reduces the biological activity of the drug. This is the main reason for the increase in clinical allergic reactions caused by the deproteinized calf blood extract solution. With the prolongation of time, the incidence of adverse reactions also increases immediately, and in clinical medication, calf blood deproteinized extract solution is dissolved in sugar and saline for use, which not only increases the probability of drug contamination, but also affects the safety of drug use sex, but also increases the workload of medical staff

Method used

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  • Veal-blood protein-removed extract infusion and its preparation process

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Effect test

Embodiment 1

[0018] Calf blood deproteinized extract infusion and its preparation process, its composition includes: calf blood deproteinized extract and osmotic pressure regulator, the calf blood deproteinized extract is extracted from calf blood or serum , the calf blood deproteinized extract solid contains total nitrogen and amino acids, its parts by weight are amino acid 20.0, total nitrogen 12.5, osmotic pressure regulator 50, pH value should be 5.5, this product is light yellow or light yellow Yellow clear liquid. The preparation process is as follows: take 16,500 parts by weight of calf blood, filter to obtain a crude filtrate with 16,000 parts by weight, adjust the pH to 4.5, and centrifuge to obtain a supernatant with 15,000 parts by weight, and adjust the pH value to 7.5, centrifuged to obtain a supernatant of 12,000 parts by weight, take the supernatant, adjust the pH value to 6.5, heat-treat at 70°C, centrifuge, concentrate under reduced pressure at 60°C to obtain a concentrate...

Embodiment 2

[0020] Calf blood deproteinized extract infusion and its preparation process, its composition includes: calf blood deproteinized extract and osmotic pressure regulator, the calf blood deproteinized extract is extracted from calf blood or serum , the calf blood deproteinized extract solid contains total nitrogen and amino acids, its parts by weight are amino acid 30.0, total nitrogen 18.75, osmotic pressure regulator 100, pH value should be 8.0, this product is light yellow or light yellow Yellow clear liquid. The preparation process is as follows: take 24,800 parts by weight of calf blood, filter to obtain a crude filtrate with 24,000 parts by weight, adjust the pH value to 5.0, and centrifuge to obtain a supernatant liquid with 23,000 parts by weight, and adjust the pH value to 8.0, centrifuged to obtain a supernatant of 20,000 parts by weight, take the supernatant, adjust the pH value to 7.5, heat-treat at 90°C, centrifuge, concentrate under reduced pressure at 80°C to obtai...

Embodiment 3

[0022] Calf blood deproteinized extract infusion and its preparation process, its composition includes: calf blood deproteinized extract and osmotic pressure regulator, the calf blood deproteinized extract is extracted from calf blood or serum , the calf blood deproteinized extract solid contains total nitrogen and amino acids, its parts by weight are amino acid 25.0, total nitrogen 15.5, osmotic pressure regulator 70, pH value should be 6.5, and this product is light yellow or light Yellow clear liquid. The preparation process is as follows: take 22,800 parts by weight of calf blood, filter to obtain a crude filtrate with 22,000 parts by weight, adjust the pH value to 4.7, and centrifuge to obtain a supernatant liquid with 22,000 parts by weight, and adjust the pH value to 7.8, centrifuged to obtain a supernatant of 15,000 parts by weight, take the supernatant, adjust the pH value to 7.0, heat-treat at 80°C, centrifuge, concentrate under reduced pressure at 70°C to obtain a c...

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Abstract

The invention is calf dehemoglobinize extract transfusion and its manufacturing method. The amino acid and small peptide in the extract of the calf dehemoglobinize can be polymerized into high molecular peptide and large molecular weight peptide, thus the medicine has antigenicity and reduces the biology activity of the medicine, and causes the increase of clinic hypersusceptibility. The ingredients of the calf dehemoglobinize are: the calf dehemoglobinize extract and osmotic pressure regulator, the calf dehemoglobinize extract is extracted from the calf blood or blood serum, the extract solid contains nitrogen and amino acid, its weight shares are: amino acid is 20.0-30.0, the nitrogen 12.5-18.75, the osmotic pressure regulator 50-100, pH value is 5.5-8.0, the product is a little yellow or yellow transparent liquid. The product can be applied to cure cerebral ischemia, cerebral dementia, brain trauma and incompetence of brain fucntiosn, and so on, they are all brain cell metabolism handicap diseases; it also can be applied to cure the twig artery, vein circulation obstruction, and artery angiopathy.

Description

Technical field: [0001] The invention relates to a deproteinized calf blood extract transfusion and a preparation process thereof. Background technique: [0002] The calf blood deproteinized extract solution is mainly composed of amino acids, small peptides and other nitrogen-containing compounds. Amino acids and small peptides can be polymerized with each other in a natural state to form large molecular weight peptides, and peptides can be polymerized into high molecular weight peptides. Precipitation in the form of polymers or existing in the solution in the form of high-molecular peptides makes the drug produce antigenicity and reduces the biological activity of the drug. This is the main reason for the increase in clinical allergic reactions caused by the deproteinized calf blood extract solution. With the prolongation of time, the incidence of adverse reactions also increases immediately, and in clinical medication, calf blood deproteinized extract solution is dissolved...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/14A61K38/02A61K9/08A61P25/00A61P25/28A61P9/00A61K35/16
Inventor 江卫世
Owner 江卫世
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