Injectio of brain protein hydrolysate and its preparing process

Abstract

Disclosed is an injection of brain protein hydrolysate and its preparing process wherein the injection comprises amino acid 337-1376, polypeptides 65.9-201.25, osmoregulation agent 0-100, the amino acid and polypeptides are prepared from the brain tissue of healthy mammal through ester removing, enzyme hydrolysis, hyperfiltration, and chromatography refining.

Description

Technical field: [0001] The invention relates to a brain protein hydrolysate injection and its preparation process. Background technique: [0002] Cerebroprotein hydrolysate injection is a sterile aqueous solution that uses the brain of healthy mammals as raw materials and is refined by enzymatic hydrolysis. It is clinically used to treat cerebrovascular decompensation, craniocerebral injury, olive body pons and cerebellar atrophy, cerebral insufficiency and dysfunction, post-stroke dementia, inattention and memory impairment. It can also be combined with oxygen therapy or ventilator assisted breathing. It is better than oxygen therapy or ventilator assisted breathing in clinical treatment of chronic respiratory failure, improvement of patients' mental and neurological symptoms, shortening of the treatment course and therapeutic effect. In addition, it can assist in the treatment of children's brain Developmental dysplasia, organic syndrome and severe brain infections secondary t...

AI Technical Summary

Problems solved by technology

[0003] The main components of cerebroprotein hydrolyzate solution are amino acids and polypeptides. Peptides are easy to polymerize into polymers during storage. Although the storage time is prolonged, the number of polymers increases, which causes the incidence of allergic reactions in clinical applications to increase. Allergic symptoms such as skin rash, fever, and hypotension appeared on the 5th and 6th day, so the problem of adverse reactions caused by polymer substances seriously affected the clinical application of the drug