Flavonoid extract product containing pedaliin and application

A technology of flavonoids and extracts, which is applied in the field of flavonoids extracts, can solve the problems of not being able to clearly determine the content of catalin and its biological activity, and achieve the effects of no toxic side effects, good reproducibility, and fast and accurate methods

Inactive Publication Date: 2006-07-26
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Zhang Xiaofeng et al. isolated 5 flavonoids from Tangut Qinglan, which were identified by chemical and spectroscopic analysis as: genoside, cosmoside, flaxenin, marin, and marin-6″-acetate, but not It can clearly determine the content and biological activity of catalin in its flavonoid extract; other pharmacological effects have not been reported yet

Method used

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  • Flavonoid extract product containing pedaliin and application
  • Flavonoid extract product containing pedaliin and application
  • Flavonoid extract product containing pedaliin and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0101] 2. Preparation of Experimental Samples

[0102] After the medicinal materials are pulverized by a pulverizer, pass through a 40-mesh sieve, take 0.5g of each batch of medicinal material powder, accurately weigh them, put them in a 50mL conical flask with a stopper, add 25ml of 50% methanol, ultrasonically extract for 30min, and filter with a microporous membrane. Take the continued filtrate as the test solution.

[0103] Take 0.1g of the effective part DT, weigh it accurately, put it in a 50mL volumetric flask, add an appropriate amount of 50% methanol, and dissolve it in ultrasonic for 30min. Test solution.

[0104] 3. Chromatographic conditions

[0105] Chromatographic column: Symmetry Shield Rp18 (5μm 4.6mm×250mm)

[0106] Mobile phase: methanol (A)-0.025mol / L phosphoric acid (B) gradient,

[0107] 0min: 40(A): 60(B)

[0108] 60min: 50(A): 50(A)

[0109] Detection wavelength: 347nm

[0110] Column temperature: 30°C

[0111] Flow rate: 0.5mL / min

[0112] Inje...

Embodiment 1

[0151] Embodiment 1: injection

[0152] Flavonoid extract containing catalin 10g

[0153] Benzyl alcohol 10g

[0154] Add water for injection to 1000ml

[0155] Make injection 1000ml altogether.

Embodiment 2

[0156] Embodiment 2: tablet

[0157] Flavonoid extract containing catalin 10g

[0158] Starch 50g

[0159] 20g powdered sugar

[0160] Dextrin 20g

[0161] Conventional tableting, 1000 tablets, 0.1g per tablet.

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Abstract

This invention relates to an extract from Chinese herb medicine raw material such as Ganqing Qinglan. It is a flavone-type compound, contg. pedaliin. This invented product can be used for treating cerebral blood-lack and cerebral oxygen-lack, cerebrovascular disease, cerebro-apoplexia disease. Advantages are; simple extraction method, excellent purification effect, obvious therapeutic effect, new use for treating cerebral diseases.

Description

technical field [0001] The present invention relates to a kind of flavonoid extract from traditional Chinese medicine raw material drug, especially relates to the flavonoid extract containing catemin from Ganqing Qinglan raw material drug; Application in diseases and pharmaceutical composition containing the extract. Background technique [0002] Tibetan medicine Ganqing Qinglan is the dry aboveground part of Lamiaceae plant Ganqing Qinglan (Tangut Qinglan) Dracocephalumtanguticum Maxim. Distributed in southwestern Gansu, eastern Qinghai, western Sichuan, and southeastern Tibet. It grows in alpine shrub forests, edges of pine forests, gravel grass slopes, and banks of dry river valleys at an altitude of 1900-4600m. This product has the functions of clearing heat and dampness, dispelling wind and relieving the exterior, soothing the liver and harmonizing the stomach, clearing liver heat and stomach heat, stopping bleeding, healing sores, and drying yellow water. It is used f...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/10C07H17/07C07H1/08C07D311/30C07G3/00A61K31/7048
Inventor 张文生杜树山史培军王永炎
Owner BEIJING NORMAL UNIVERSITY
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