30 results about "Cerebral oxygen" patented technology

Methods and apparatus for measuring cerebral O2 saturation and detecting cerebral hypoxia-ischemia using multi-wavelength near infrared spectroscopy (NIRS). Near-infrared light produced by an emitter is directed through brain tissue. The intensity of the light that passes through the brain tissue is measured using photodiode detectors positioned at distinct distances from the emitter. This process is conducted for at least three wavelengths of near-infrared light. One of the wavelengths used is substantially at an isobestic point for oxy-hemoglobin and deoxy-hemoglobin, but the other two may be any wavelengths within the near-infrared spectrum (700 nm to 900 nm), so long as one of the additional wavelengths is greater than the isobestic point and the other is less than the isobestic point. Tissue oxygenation is calculated using an algorithm derived from the Beer-Lambert law. Cerebral hypoxia-ischemia may be diagnosed using the calculated tissue oxygenation value.

A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter.

The invention relates to an opto-acoustic brain function imaging method. The method realizes imaging of brain blood vessel structure distribution observation and function monitoring via the opto-acoustic tomographic image of the cortex blood vessels. Brain damage and cerebral hemorrhage variation degree can be monitored, and the parameters such as cerebral blood flow, brain oxygen consumption and brain oxygen saturation etc can be reflected via the blood vessel form distribution, blood diameter variation and opto-acoustic signal intensity variation of blood vessels. The laser generation component, acoustic signal acquisition component and computer among the devices realizing the mentioned method are electrically connected in turn. The rotary scanning mechanism is electrically connected with the computer. The sample fixation components are connected with the acoustic coupling components in turn. The invention is characterized by convenient operation and sensitive and quick performance, can make imaging analysis of blood vessels without damage, and then monitor brain function, which can thus provide imaging basis for brain function judgment.

A method for preventing or reducing hemispheric cerebral oxygen desaturation in a subject undergoing surgery, wherein the method comprising the prophylactic administration of a vasodilator to the subject.

A system and method for accurately producing MR images of selected vascular compartments includes employing a control scan and a tag scan, each including velocity selective modules that suppress signal from blood flowing faster than a given cutoff velocity, to acquire control and tag sets of NMR data that may be subtracted to produce a compartment-specific MR image that is substantially free of information from stationary tissues and blood outside the selective vascular compartments. Accordingly, physiological parameters, such as oxygen saturation (SaO2), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2), can be generated from the compartment-specific images. Further still, kinetic curves of oxygen exchange can be created, thus providing detailed insight into oxygen exchange dynamics.

The electric bed includes a bed board with adjustable back and foot raising part, bed frame, bed frame supporting elevator to change the bed state, be bottom skeleton to support the elevator, and bed motion controller. It may be manually controlled to stop in several bed states or be control to alter in different bed states or move in different modes automatically. It utilzies gravity to promote blood circulation and has the functions of making lung disease patient to lie inversely to eliminate phlegm, performing cerebral oxygen supply in lower-head and higher feet state, rehabilitation, etc.

A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter.

A system and method for non-invasively estimating the tissue blood oxygen saturation level of a human subject, including so-called “outliers”, whose physiological make-up causes previously-known techniques to generate invalid tissue blood oxygen saturation estimations. The system includes a computing device and a sensor. The sensor includes a light source configured to emit light of at least four different wavelengths, one at a time. The sensor also includes two light detectors, each positioned a different distances from the light source. Optical density measurements are taken by the light detectors and provided to the computing device. A first tissue blood oxygen saturation value is computed using the optical density measurements associated with three of the four wavelengths, and a second tissue blood oxygen saturation value is computed using the optical density measurements associated with four of the wavelengths. The first and second tissue blood oxygen saturation values are compared, and the human subject is identified as an “outlier” based upon that comparison.

The invention relates to the technical field of medicines, and provides a composition capable of improving memory as well as a preparation method and application thereof. The composition capable of improving memory comprises nicotinamide mononucleotide, taurine, phosphatidylserine, ginsenoside PPD, ginsenoside Rh2, chondroitin sulfate, ursodesoxycholic acid, sialic acid, s-ademetionine, gamma-aminobutyric acid, astaxanthin, a grape seed extract and pyroglutamic acid esters. The composition capable of improving memory has great effects on increasing cerebral oxygen supply, accelerating cerebralblood circulation and improving memory; moreover, the composition is simple in prescription and low in price. The invention further provides the preparation method and the application of the composition capable of improving memory.

The utility model relates to a test method and device for respiratory system function. The device comprises: a breathing gas circuit unit, an oscillating pressure generating unit, a pressure and flowdetection unit, an oxygen and nitrogen concentration control unit, a gas concentration sensor, and one-way valve or air-resistor, a cerebral oxygen metabolism detection unit, a data acquisition and control unit, a computing unit. The mechanical properties of the respiratory system are measured while the gas exchange, oxygen metabolism and reserve capacity of the cardiopulmonary system are assessed, high-frequency gas oscillations are produced by forced oscillation technique, and the respiratory system of a subject is stimulated, the mechanical characteristics of respiratory system are obtainedby the system identification algorithm, while the forced oscillation excitation is detected, the concentration and duration of inhaled oxygen and nitrogen are controlled, the oxygen saturation curveand descent curve are determined, the time-delay and time constant are determined, and the gas exchange, oxygen metabolism efficiency and oxygen reserve capacity of the subject are evaluated accordingly.

The invention discloses a blood parameter and electrophysiological parameter detection method based on photoelectric fusion. The method is oriented to electroencephalogram and electroencephalogram oxygen data acquisition, electroencephalogram and electroencephalogram oxygen data of a brain area of a patient are acquired through a flexible patch sensor, and acquired signals are transmitted to an upper computer through a wireless transmission module for signal processing; artifact information in the signals can be removed by preprocessing the signals through the upper computer, and the signal-to-noise ratio of the signals is increased; features in the electroencephalogram and electroencephalogram oxygen signals are extracted through a moving window, and anesthesia depth related indexes are calculated and predicted; and the data is transmitted through the wireless transmission module, so that the problem that a data transmission line is easy to damage is solved. The electroencephalogram signals are applied to the anesthesia depth monitoring method, and the problem that the electroencephalogram signals are interfered and cannot be used is solved.

The invention discloses a method for dynamically measuring cerebral oxygen metabolism rate. According to the method, a perfusion multiecho asymmetric spin echo technology are adopted, namely, a multiecho signal acquisition mode formed by alternately switching a layer selection inversion mark and a non-layer selection inversion mark is adopted, oxygen extraction fraction (OEF) and cerebral blood flow (CBF) weighted images are synchronously obtained in a mode of adding / subtracting layer selection signals and non-layer selection signals, and measurement of dynamic change of the cerebral metabolicrate of oxygen (CMO2) is finally realized by combining Fick's law. According to the invention, a series of problems caused by gas calibration required by calibrating a blood oxygen level dependent (BOLD) method are fundamentally solved, so that the comfort level of a subject is greatly improved, the applicable population is enlarged, and complexity of operation and measurement cost are greatly reduced. Furthermore, research on brain health and brain disease mechanisms of different populations is expected to be established, and development of neuroscience and clinical medicine is promoted.

The invention relates to a detection device and a manufacturing method thereof, and the device comprises an electrode assembly which is used for receiving an electroencephalogram signal of a detected object; a light source assembly used for emitting light waves to the detected object; a photoelectric detection component used for receiving an optical signal obtained after the optical waves are reflected or scattered by the brain of the detected object, and performing photoelectric conversion on the optical signal to obtain a brain oxygen detection signal; a processing component used for respectively processing the electroencephalogram signal and the brain oxygen detection signal and respectively acquiring a first detection result and a second detection result of the brain of the detected object; and a flexible substrate used for bearing the electrode assembly, the light source assembly and the photoelectric detection assembly. The multi-channel electroencephalogram and brain oxygen synchronous same-area detection is performed on the detected object, and the flexible substrate is adopted for bearing, so that higher time resolution and spatial resolution can be ensured, the detection accuracy is improved, the natural integration of the detection device and the detected object is realized, the anti-interference capability is effectively improved, and the robustness is good.

A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third NIR wavelengths across the brain of the subject. The first NIR wavelength is the isosbestic wavelength for oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb), the second NIR wavelength is shorter than the first NIR wavelength, and the third NIR wavelength is longer than the first NIR wavelength. The detecting means (220) includes a first, second and third detectors (221, 222, 223) for respectively detecting the NIR intensities of the first, second and third NIR wavelengths traveled across the brain. The processor (230) is configured to determine blood oxygen level based on the measured NIR intensities of the first, second and third NIR wavelengths by use of build-in algorithm derived from Beer-Lambert Law. And method of detecting brain hematoma of a subject by use of the present device.

The invention discloses a dynamic brain function dual-mode imaging system based on fluorescence and photoacoustic tomography, which organically combines the two measurement methods of FMT / PAT, so thatthe source and probe of FMT and PAT are distributed on the same horizontal plane in order to avoid the difference in registration position of joint imaging, to achieve high sensitivity, high spatio-temporal resolution and full-brain range imaging dual-mode multi-parameter dynamic imaging of brain function and to take into account the high sensitivity of FMT in dynamics research and advantages ofPAT in high spatial resolution. PAT provides images of deep cerebral oxygen state related to nerve activity, including oxyhemoglobin concentration, deoxyhemoglobin concentration, blood oxygen saturation, etc. FMT provides fluorescence distribution images and kinetic parameter images, including fluorescence metabolism curves, permeability images, etc. The system has both high resolution of PAT andhigh sensitivity of FMT to realize imaging of cranial nerve activity.

The invention discloses a near-infrared cerebral oxygen detection system and method. The near-infrared cerebral oxygen detection system is provided with multiple detection units, thereby being conductive to improving the detection resolution ratio; in addition, near-infrared light sources and photoelectric sensors are staggeredly arranged, thereby reducing the reception of interference signals toreduce the noise of the interference signals, effectively improving the accuracy and precision of cerebral blood oxygen data, and solving the technical problem of low data precision of a near-infraredspectrum cerebral oxygen detection system in the prior art. In addition, the near-infrared cerebral oxygen detection system adopts a producer / customer mode in data reading and processing links, thereby effectively improving the running efficiency of a program, increasing the acquisition speed of the cerebral blood oxygen data, and improving the real-time property of data acquisition.

The invention relates to a multi-sensor deep hot probe. By adding multiple sensors including pressure sensors, temperature sensors, cerebral oxygen saturation sensors and the like on probe contacts and a medical catheter, multi-sensor monitoring can be realized during implantation and after implantation. Through the probe contacts arranged linearly in the direction of the medical catheter and arranged in a circumferential direction, after a lesion position is discovered, directional controllable-range thermal coagulation can be performed on the lesion position; the lead impedance of the probeis low; and the thermal coagulation effect is good.

The invention discloses a cerebral blood flow autonomous regulation ability assessment method. The method comprises the following steps of: acquiring target tissue oxygen saturation and target average arterial pressure; obtaining a time-frequency map according to the target tissue oxygen saturation and the target average arterial pressure; determining a target time-frequency band from the time-frequency map, wherein the target time-frequency band comprises a time-frequency band in which the consistency of the target tissue oxygen saturation and the target average arterial pressure exceeds a preset threshold value; and, according to the mutual relation between the tissue oxygen saturation and the average arterial pressure in the target time-frequency band, assessing the cerebral blood flow autonomous regulation ability. Compared with a brain oxygen saturation index algorithm which only considers the time-domain correlation between the tissue oxygen saturation and the average arterial pressure, the invention has the advantages that: the time-domain correlation and the frequency-domain correlation between the tissue oxygen saturation and the average arterial pressure are considered at the same time, so that the autonomous regulation capability of cerebral blood flow can be evaluated more comprehensively, and the accuracy of assessing the autonomous adjustment ability of cerebral blood flow can be improved.

The invention discloses a method for controlling equipment based on brain signals, its control equipment, and a human-computer interaction system. By periodically acquiring brain electrical signals and brain oxygen signals within a preset period of time, the representative brain electrical signals and brain oxygen signals are respectively generated. EEG waveform curves and brain oxygen waveform curves whose values ​​change within a preset period; determine whether the EEG waveform curves and brain oxygen waveform curves meet the conditions for controlling the controlled device to perform preset operations; When the oxygen waveform curve meets the conditions, the controlled equipment is controlled to perform preset operations. Compared with the method of controlling equipment based only on EEG signals in the prior art, the above-mentioned equipment control method provided by the present invention simultaneously detects EEG signals and brain oxygen signals to generate EEG waveform curves and brain oxygen waveform curves, two kinds of data At the same time, it matches and judges the conditions for controlling the controlled equipment to perform preset operations, which can avoid misoperation caused by single data jumps and other situations, and improve the accuracy of the controlled equipment.

The invention discloses an intravenous injection medication method for cardia-cerebrovascular diseases. The compatibility of medicines comprises pulse-activating powder, radix astragali, flos carthami, a Qingkailing compound, tetramethylprazine, radix salviae miltiorrhizae, puerarin, vitamin C and a dexamethasone sodium phosphate injection; all preparations are proportioned according to the stipulation of the specification, and the injection consists of pulse-activating powder, radix astragali, flos carthami, the Qingkailing compound, tetramethylprazine, radix salviae miltiorrhizae, puerarin,vitamin C, dexamethasone sodium phosphate, 0.9% sodium chloride and a 5% glucose injection. The using method comprises the following steps: taking the preparations to be dissolved into 250 ml or 500 ml of 0.9% sodium chloride or 5% glucose injection respectively every day, and carrying out intravenous drip, once a day for 15 days as a course of treatment. The intravenous injection medication method is simple in operation, high in cure rate, low in price, convenient for material drawing and free of risk, and also has the effects of effectively curing and dilating coronary artery and blood vessels of brain, increasing coronary flow, reducing cardiac and cerebral oxygen consumption, reducing blood viscosity, resisting platelet aggregation, improving microcirculation and enhancing immunologicfunction; and moreover, the combination of Chinese traditional and Western medicine also highlights the characteristics of Chinese traditional medicine.

The application provides a method and system for removing physiological noise on a surface layer, relating to the field of medical technology. The method for removing physiological noise on the surface layer comprises the following steps: firstly, pre-processing collected relative change signals of oxyhemoglobin concentrations in all channels; then, respectively using Morlet wavelets in complex number fields to perform continuous wavelet transform on relative change signals of oxyhemoglobin concentrations and extracting changed a phase-angle matrix of relative change signals of oxyhemoglobin concentrations; next, expanding phase-angle matrixes, utilizing a high-pass filter and a low-pass filter to divide the phase-angle matrix into a high-frequency part and a low-frequency part and utilizing a self-adaptive filtering method to remove noise of the high-frequency part in a self-adaptive manner; and finally, overlapping the low-frequency part of a main channel and the de-noised high-frequency part to obtain the phase-angle matrix of the main channel with physiological noise of the surface layer de-noised. The method helps eliminate physiological interference of the surface layer from cerebral oxygensignals, thereby acquiring cleaner brain tissue signals.

This invention relates to an extract from Chinese herb medicine raw material such as Ganqing Qinglan. It is a flavone-type compound, contg. pedaliin. This invented product can be used for treating cerebral blood-lack and cerebral oxygen-lack, cerebrovascular disease, cerebro-apoplexia disease. Advantages are; simple extraction method, excellent purification effect, obvious therapeutic effect, new use for treating cerebral diseases.

The invention discloses a cardio-pulmonary resuscitation feedback control method and system, and relates to the technical field of medical care. The method comprises the steps of collecting brain oxygen signals of a patient; preprocessing the brain oxygen signals of the patient; separating out first signals and second signals from the preprocessed brain oxygen signals through independent componentanalysis, wherein the first signals are cardio-pulmonary resuscitation signals, and the second signals are spontaneous circulation signals; according to the first signals and the second signals, adjusting and controlling cardio-pulmonary resuscitation of the patient. By means of the method and system, the technical problems in the prior art that during cardio-pulmonary resuscitation, whether or not the patient restores spontaneous circulation is difficult to judge, cardio-pulmonary resuscitation has negative effects, and the patient cannot be effectively cured are solved. The curative rate ofcardio-pulmonary resuscitation can be greatly increased, and the method and system have the technical advantages of being high in pertinence, noninvasive, high in safety coefficient and easy to operate.

A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third NIR wavelengths across the brain of the subject. The first NIR wavelength is the isosbestic wavelength for oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb), the second NIR wavelength is shorter than the first NIR wavelength, and the third NIR wavelength is longer than the first NIR wavelength. The detecting means (220) includes a first, second and third detectors (221, 222, 223) for respectively detecting the NIR intensities of the first, second and third NIR wavelengths traveled across the brain. The processor (230) is configured to determine blood oxygen level based on the measured NIR intensities of the first, second and third NIR wavelengths by use of build-in algorithm derived from Beer-Lambert Law. And method of detecting brain hematoma of a subject by use of the present device.

The invention provides a self-adaptive control blood pump supply method. The self-adaptive control blood pump supply method comprises the following steps of collecting and processing a pulse signal; calculating a heart rate value according to the preprocessed pulse signal; and driving a servo motor to act according to the heart rate value so as to adjust the flow of an artificial blood pump. According to the method, heart blood pumping of a patient can be simulated, extracorporeal circulation blood perfusion generates pulse blood flow according with the patient, local brain oxygen saturation is improved, microcirculation of human tissue is improved, and blood pump parameters can be automatically adjusted according to different heart pulse frequencies of different patients, so that a blood transfusion process better conforms to the physiological characteristics of the patient. Correspondingly, the invention further provides a self-adaptive control blood pump supply system.

The invention provides a remote noninvasive brain oxygen saturation monitoring device. The remote noninvasive brain oxygen saturation monitoring device comprises a wearable helmet or glasses, an acquisition module for noninvasively acquiring brain oxygen saturation data in real time, a wireless signal transmitting system, a terminal system and a remote brain oxygen data processing and analyzing system, wherein the wearable helmet or glasses are used for fixing the acquisition module, the wireless signal transmitting system is connected with the acquisition module so as to be used for transmitting acquired data to the terminal system, and the remote brain oxygen data processing and analyzing system is used for processing and analyzing the data received by the terminal system. According to the remote non-invasive brain oxygen saturation monitoring device, non-invasive brain oxygen saturation analysis is carried out on a patient suffering from severe heatstroke brain injury, a remote information processing mode is designed, and the remote non-invasive brain oxygen saturation monitoring device can be applied to early detection of brain injury so as to carry out early warning and continuously monitor the brain injury degree so as to guide effective intervention.

The invention relates to an intelligent monitoring system and method for a cardio-pulmonary resuscitator, and the system comprises the cardio-pulmonary resuscitator, a control terminal, a mobile terminal, a cloud database, an electrocardiogram collection unit, a brain oxygen signal collection unit, and a carotid pulse collection unit. According to the cardiopulmonary resuscitator, the appropriate first pressing parameter and the appropriate second oxygen supply parameter can be intelligently obtained, and the second pressing parameter and the second oxygen supply parameter can be obtained according to the fed-back electrocardiogram signal, the brain oxygen signal and the neck pulsation signal, so that the cardiopulmonary resuscitator of different models can be intelligently monitored by different people; and the accuracy and rescue effect of cardio-pulmonary resuscitation are further improved.

The invention discloses ischemia adaptation training equipment with the function of brain oxygen monitoring. The equipment comprises a training equipment body, a touch control module is embedded in the center of the front end of the training equipment body, an emergency stop button is mounted at the bottom of the center of the front end of the training equipment body, a power on-off button is mounted at the bottom of the center of the front end of one side of the training equipment body, a protection door plate is mounted at the top of the center of the rear end of one side of the training equipment body, and the protection door plate and the training equipment body are fixedly connected through a lock catch assembly. Two sliding rods and auxiliary straight rods are mounted in a containing chamber formed in the training equipment body, and two corresponding first cylindrical pulleys, two shaft sleeve sliding seats and a set of second cylindrical pulleys are arranged. Through the above structures, a moving table is driven to make linear reciprocating motion, and a mounting table on the moving table is moved to the outside of one side of the training equipment body, so that the use of medical personnel is facilitated, and the automation degree is high.

An assistive device for guiding performance of cardiopulmonary resuscitation (CPR) during cardiac arrest (CA), comprising an intelligent device and algorithm that present care givers realtime guidance and feedback on CPR quality using input from multiple invasive and noninvasive biometric monitoring devices. Input is combined and processed using artificial intelligence (AI) techniques to provide performance guidance displayed on a single monitor. Inputs include at least (a) heart rate, (b) end-tidal carbon dioxide—ETCO2, and (c) regional cerebral oxygen saturation—RSO2, which are processed to evaluate effectiveness of ongoing CPR and provide performance indicators in real time directed to increasing CPR effectiveness. Artificial intelligence functions evaluate effectiveness of CPR against standards of care as CPR is performed and provides actionable guidance to improve performance. Outputs are produced that include at least (a) performance parameters for compressions, (b) ventilation effectiveness, and (c) indication if return of spontaneous circulation (ROSC) has occurred.