Interpenetrating network polymer type super porous aquogel, its prepn. method and application

A technology of porous hydrogel and interpenetrating network is applied in the field of interpenetrating network polymer superporous hydrogel and its preparation, which can solve the problems of inflexibility, brittleness, and inappropriate oral administration of protein and polypeptide drugs, etc. Achieve the effect of increasing mechanical strength, inhibiting protease, and protecting protein and polypeptide substances

Inactive Publication Date: 2007-02-28
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the mechanical strength of the second-generation superporous hydrogel SPHC has been improved, when it is fully swollen, it is brittle because it is not elastic, and it is brittle under the action of various external forces.
The water-soluble polymers used in the above polymers are polyvinyl alcohol and polyethylenediamine. Due to the limitations of the properties and toxicity of polyvinyl alcohol and polyethylenediamine, they are not suitable as carriers for oral administration of protein and polypeptide drugs.

Method used

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  • Interpenetrating network polymer type super porous aquogel, its prepn. method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 poly(acrylic acid-acrylamide) IPN-SPH containing chitosan

[0048] In a tall weighing bottle (40mm×25mm), add the following components in sequence: 300μl 50% AM (acrylamide); 200μl 50% AA (acrylic acid); 100μl 2.5% BIS (N, N'-methylene -bisacrylamide); 300 μl DDW (double distilled water); 30 μl 10% Pluronic  F127 (PF127, poloxamer); 25 μl 20% APS (ammonium persulfate); 25 μl 20% TEMED (N,N,N',N'-tetramethylethylenediamine); 300 μl 4% shell Glycans (dissolved in 2% acetic acid). After each ingredient is added, the solution is vortexed to mix. Add 120 mg of sodium bicarbonate 2 minutes before gelation occurs and vortex. Place the above-mentioned ultraporous hydrogel polymer containing chitosan in HCl / absolute ethanol (3:7, v / v) containing 1% glutaraldehyde for 2h to obtain the poly( Acrylic acid-acrylamide) IPN-SPH.

Embodiment 2

[0049] Embodiment 2 contains poly(acrylic acid-acrylamide) IPN-SPH of chitosan hydrochloride

[0050] In a tall weighing bottle (40mm × 25mm), add the following ingredients in turn: 300μl 50% AM (acrylamide): 200μl 50% AA (acrylic acid); 100μl 2.5% BIS (N, N'-methylene -bisacrylamide); 300 μl DDW (double distilled water); 30 μl 10% Pluronic  F127 (PF127, poloxamer); 25 μl 20% APS (ammonium persulfate); 25 μl 20% TEMED (N,N,N',N'-tetramethylethylenediamine); 300 μl 4% shell Polysaccharide hydrochloride. After adding each ingredient, the solution was vortexed to mix. Add 120 mg of sodium bicarbonate 2 minutes before gelation occurs and vortex. Place the above-mentioned ultraporous hydrogel polymer containing chitosan hydrochloride in HCl / absolute ethanol (3:7, v / v) containing 1% glutaraldehyde for 2h to obtain chitosan-containing Poly(acrylic acid-acrylamide) IPN-SPH hydrochloride.

Embodiment 3

[0051] Embodiment 3 contains the poly(acrylic acid-acrylamide) IPN-SPH of chitosan trimethyl quaternary ammonium salt (TMC)

[0052] In a tall weighing bottle (40mm×25mm), add the following components in sequence: 300μl 50% AM (acrylamide); 200μl 50% AA (acrylic acid); 100μl 2.5% BIS (N, N'-methylene -bisacrylamide); 300 μl DDW (double distilled water); 30 μl 10% Pluronic F127 (PF127, poloxamer); 25 μl 20% APS (ammonium persulfate); 25 μl 20% TEMED (N, N, N', N'-tetramethylethylenediamine); 300 μl 8% TMC . After adding each ingredient, the solution was vortexed to mix. Add 120 mg of sodium bicarbonate 2 minutes before gelation occurs and vortex. The above-mentioned superporous hydrogel polymer containing TMC is placed in HCl / dehydrated alcohol (3:7, v / v) containing 1% glutaraldehyde for 4h, and then trimethyl quaternary ammonium containing chitosan can be obtained. Poly(acrylic acid-acrylamide) IPN-SPH of salt (TMC).

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Abstract

A super-porous aqueo-gel of an interpenetrating network polymer used for the orally applying system of protein polypeptide to suppress proteinase and break the close linking between epithelial cells contains two polymers: a cross-linked polymer and a cross-linked polyose polymer. Its preparing process includes such steps as mixing at least one unsaturated enylmonomer, at least one polyenyl cross-linking agent, a linear polyose polymer and a foaming agent to generate the super-porous aqueo-gel of semi-interpenetrating network polymer, and cross-linking with linear polyose.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to an interpenetrating network polymer superporous hydrogel, a preparation method thereof and an application in pharmacy. Background technique [0002] Hydrogels are cross-linked hydrophilic polymers containing a network structure. It is insoluble in water but absorbs large amounts of water. The study of hydrogel began in the 1960s. Due to its biocompatibility and biodegradability, it can be widely used in the fields of medicine, biology and pharmacy. So far, a variety of hydrogels have been invented. gel. [0003] Interpenetrating Polymer Networks (IPN) is a class of heterogeneous multi-component polymer materials, composed of two or more polymer networks formed by permanent entanglement between macromolecular chains (or Interpenetrating) to form unique polymer alloys whose polymer networks are cross-linked with each other, or both polymerized and cross-lin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08F299/00C07K17/08A61K47/36
Inventor 印春华殷黎晨唐翠
Owner FUDAN UNIV
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