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Medicinal mixture possessing alpha glycocidase inhibiting activity and its use

A technology of glycosidase inhibitor and composition, applied in the field of pharmaceutical compositions, can solve the problems of not involving the preparation method and application of flavonoid α-glycosidase inhibitor, and not involving combined use, etc., and achieves clear action mechanism and exact curative effect. Effect

Active Publication Date: 2005-01-05
LONGSHUNRONG PHARMA FACTORY TIANJIN ZHONGXIN PHARMA GRP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese patent application No. 01113191.8 discloses "Chinese medicine extract with α-glucosidase inhibitor activity, its preparation method and application". The preparation method and application of flavonoid α-glucosidase inhibitors, and there is no report involving the combined use of the above-mentioned alkaloids and flavonoids to significantly enhance the effect of α-glucosidase inhibitors

Method used

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  • Medicinal mixture possessing alpha glycocidase inhibiting activity and its use
  • Medicinal mixture possessing alpha glycocidase inhibiting activity and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～16

[0028] Embodiment 1~16 is listed in table 1

[0029] Number of examples

Embodiment 27

[0031]The method of the total alkaloids extracted from mulberry branches: 1000g of mulberry branches, add 5L of ethanol with a volume percentage content of 50%, keep warm at 70°C for 3 hours, filter, add 5L of 50% ethanol to the filter residue, soak overnight after boiling, filter , combine the two filtrates, concentrate to 1-2 times the original volume, centrifuge, stand still, add ethanol to precipitate overnight, filter with suction, pass the filtrate through 001×7 type cation exchange resin, elute with 0.5N ammonia solution, collect alkaloids for detection The positive part was adsorbed and decolorized by activated carbon, concentrated under reduced pressure, centrifuged, and freeze-dried to obtain 8.06 g of total alkaloids of Mori twigs.

[0032] Acid-base titration of alkaloids: Take 0.5 g of the above-mentioned dry powder, dissolve it in 20 ml of glacial acetic acid, use 0.1N perchloric acid as the titration solution, and measure the equivalent number of N atoms therein....

Embodiment 28

[0035] The method for extracting total alkaloids from mulberry branches: the steps are the same as in Example 27, using 0.05N HCl as the extraction solvent, the extraction method can be cold extraction or 50-80°C heating extraction, the volume of the extraction solvent is the weight of the extracted slices 5-15 times of that, repeat extraction 1-4 times; filter to remove medicinal residues, neutralize to neutral with NaOH, concentrate the filtrate; add ethanol precipitation to remove impurity precipitates; remove residues by centrifugation or filtration; For exchange resin, wash the non-adsorbed impurities with ion-free water and elute with ammonia water with a concentration of 0.2-1N; the eluent is concentrated under reduced pressure to remove ammonia water; decolorized by active carbon adsorption, and the decolorized solution is collected; concentrated to make a dry powder. alkaloids.

[0036] Using acid as the extraction solvent, its concentration can also be selected from ...

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Abstract

A medicine with high activity to suppress alpha-glucosidase for treating diabetes, and hyperlipemia, and delaying sanility contains the common alkaloid extracted from mulberry plants and the flavone extract.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition and its application, in particular to a pharmaceutical composition with alpha-glucosidase inhibitory activity and its application in the preparation of hypoglycemic drugs. Background technique: [0002] Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia caused by insufficient insulin secretion and / or impaired insulin action. It is manifested by an abnormal increase in the concentration of glucose in the blood and urine. When the blood sugar and urine sugar are too high, the typical symptoms of "three more and one less" will appear, that is, polydipsia, polyuria, polyphagia and weight loss, accompanied by fatigue powerless. Diabetes is called "Xiaoke Syndrome" in traditional Chinese medicine, which refers to a disease characterized by polydipsia and drinking, eliminating food and hunger, frequent urination, and emaciation. Diabetes is generally divided into type 1 di...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K35/64A61P3/06A61P3/10A61P39/06A61P43/00
Inventor 白钢杨文博耿鹏肖会姣杨洋田旺
Owner LONGSHUNRONG PHARMA FACTORY TIANJIN ZHONGXIN PHARMA GRP
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