Echinacea polysaccharide, and its preparing method and use for preparing medicines for treating antivirus and antibacterial, especially anti SARS

A technology of echinacea polysaccharide and echinacea, used in various inflammatory, antiviral and antibacterial applications

Inactive Publication Date: 2005-02-16
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extracting polysaccharides from echinacea and directly using them as medicine has not been reported at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Take 1kg of the whole plant of Echinacea purpura, make coarse powder, heat and reflux with 10kg of distilled water, extract 3 times, extract for 2 hours for the first and second times, extract for 1 hour for the third time, combine the three extracts, and use 200 mesh Filter the extract with double-layer filter cloth, take the supernatant after the filtrate stands still, use thin film evaporation to concentrate to 10kg at 60°C, add 30L of chloroform-n-butanol mixed solution with a volume ratio of 4:1, and place in a constant temperature oscillator (TH2-82), shake at 190r / min for 20min, filter and remove the precipitated protein and impurities to obtain the concentrated extract of Echinacea without protein; reclaim the organic solvent in the concentrated extract of Echinacea under reduced pressure until Remove all organic solvents; add ethanol (95%) to the concentrated extract of echinacea under stirring until the alcohol concentration of the mixed solution is 80%, precip...

Embodiment 2

[0116] Take 5kg of the whole plant of Echinacea purpurea, cut into sections, heat and boil with 25kg of distilled water to extract, extract 5 times until the active ingredients in Echinacea are basically extracted, filter the extract to remove residues, combine the extracts, and use a 100-mesh double-layer filter Filter the extract with a cloth, let the filtrate stand and take the supernatant, concentrate it under reduced pressure at 50°C to 25kg to obtain the concentrated extract of Echinacea, add 25L petroleum ether to it, stir and mix for 2 hours, centrifuge to remove protein and other For the precipitated impurities, reclaim the organic solvent under reduced pressure, add 75% ethanol to the concentrated extract of echinacea without protein under stirring until the alcohol concentration of the mixed solution is 60%, let it stand to precipitate the echinacea polysaccharide, and collect the echinacea by centrifugation Fructus inulin crude sediment, discard the supernatant. Ad...

Embodiment 3

[0118] Take 1 kg of the whole plant of Echinacea lavender, crush it or directly use the whole plant, add 20 kg of distilled water, heat and boil for extraction, until the active ingredients in the echinacea are basically extracted, filter the extract to remove residues, and take the supernatant after the filtrate is allowed to stand. Concentrate by thin film evaporation at 70°C until 4kg of concentrated extract is obtained. Under stirring, add 20L of dichloromethane and ethyl acetate mixed solution with a volume ratio of 3:1 to the concentrated extract until protein and other impurities are fully precipitated. Stand still for 10 hours, filter to remove precipitates such as protein and impurities, and recover the organic solvent under reduced pressure to obtain the concentrated extract of echinacea without protein, add 75% methanol mixed liquid alcohol to the concentrated extract of echinacea without protein under stirring The concentration is 70%, and after being fully stirred,...

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PUM

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Abstract

The invention discloses the pinecone chrysanthemum polysaccharide, its preparation method, pharmaceutical preparation with the pinecone chrysanthemum polysaccharide and its uses in curing all kinds of inflammations, improving immunologic functions, antivirus and antibiosis, especially the anti SARS medicament. It is extracted from the raw material of pinecone chrysanthemum with its total sugar content is between 75% and 95%, average molecular weight between 30,000 and 80,000. The monosackcharides in total sugar are composed of between 30% and 75% of dextrose, between 10% and 60% of fructose and between 5% and 20% of arabinose. The preparation method includes the following steps: boil the pinecone chrysanthemum and deposit it in the alcohol, dissolve the concentrated extracting solution got after boiling the pinecone chrysanthemum with polar solvent to get rid of the protein and other impurities. We deposit it with alcohol after getting rid of the polar solvent and collect the precipitatel. We get the pinecone chrysanthemum polysaccharide with its molecule weight between 3000 an d130000 after separating the precipitatel and get the powder of the pinecone chrysanthemum polysaccharide after further treatment. The pinecone chrysanthemum polysaccharide of the invention contains no other impurities, is used as medicine in the form of polysaccharide, reduces the dose, has specific curative effect, no side effects and stable quantity and is easy to control.

Description

technical field [0001] The present invention relates to a kind of echinacea polysaccharide, its preparation method, the pharmaceutical preparation containing echinacea polysaccharide and its application, specifically, the present invention relates to echinacea polysaccharide extracted from echinacea, its preparation method, containing echinacea The pharmaceutical preparation of fruit polysaccharide and its application in preparing and treating various inflammations, promoting immune function, antiviral and antibacterial, especially anti-SARS medicine belong to the field of medicine. Background technique [0002] Echinacea is a plant of the genus Echinacea of ​​the Compositae family Compositae, distributed in North America, there are about 9 species of this genus, the main medicinal species are Echinacea angustifolia, E. Purple Echinacea E.pallida. [0003] Echinacea is a botanical drug widely used abroad, especially in Europe, to treat various inflammations and promote immu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P11/00A61P29/00A61P31/04A61P31/12A61P31/14C08B37/00
Inventor 李继仁
Owner JILIN SIHUAN PHARM CO LTD
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