Medicinal composition and its preparing method and use
A composition and drug technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of unfavorable exopathogen distribution, decreased bioavailability, uneven distribution of drug solution, etc., to avoid liver damage. First-pass effect, high bioavailability, stable and controllable quality
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Embodiment 1
[0025] Embodiment 1 The preparation technology of spray agent of the present invention
[0026] 1. Composition: Houttuynia cordata 250g, honeysuckle 100g, Tween-80 0.05g
[0027] Ethyl p-hydroxybenzoate 0.03g Menthol 1.5g
[0028] 2. The specific steps are:
[0029] (1) 250g Houttuynia cordata was mixed with supercritical CO 2 method to extract volatile oil;
[0030] Extraction time 50-120min, temperature 20-60℃, pressure 10-30mPa, CO 2 The flow rate is 20-50kg / h.
[0031] (2) Flos Lonicerae 100g, add 10 times of water, steam distill to obtain 200ml of primary liquid, then carry out redistillation, collect heavy distilled liquid 40ml;
[0032] (3) Add Houttuynia volatile oil into the double distilled liquid of honeysuckle, and keep stirring;
[0033] (4) Menthol is dissolved in an appropriate amount of ethanol, and added to the redistillate;
[0034] (5) Slowly pour Tween-80 into the heavy distillation, stirring while adding;
[0035](6) Ethyl p-hydroxyben...
Embodiment 2
[0040] Embodiment 2 The preparation technology of spray agent of the present invention
[0041] 1. Composition: Houttuynia cordata 600g, honeysuckle flower 350g, Tween-80 0.10g
[0042] Ethyl p-hydroxybenzoate 0.05g Orange essence 2.0g
[0043] 2. The specific steps are:
[0044] (1) 600g Houttuynia cordata was mixed with supercritical CO 2 method to extract volatile oil;
[0045] Extraction time 50-120min, temperature 20-60℃, pressure 10-30mPa, CO 2 The flow rate is 20-50kg / h.
[0046] (2) Flos Lonicerae 350g, add 10 times of water, steam distilled to obtain 200ml of primary liquid, then carry out redistillation, collect heavy distilled liquid 40ml;
[0047] (3) Add Houttuynia volatile oil into the double distilled liquid of honeysuckle, and keep stirring;
[0048] (4) Menthol is dissolved in an appropriate amount of ethanol, and added to the redistillate;
[0049] (5) Slowly pour Tween-80 into the heavy distillation, stirring while adding;
[0050] (6) E...
Embodiment 3
[0055] Embodiment 3 The preparation process of the spray of the present invention
[0056] 1. Composition: Houttuynia cordata 400g, honeysuckle 200g, Tween-80 0.08g
[0057] Ethyl p-hydroxybenzoate 0.05g Menthol 1.5g
[0058] 2. The specific steps are:
[0059] (1) 400g Houttuynia cordata was mixed with supercritical CO 2 method to extract volatile oil;
[0060] Extraction time 50-120min, temperature 20-60℃, pressure 10-30mPa, CO 2 The flow rate is 20-50kg / h.
[0061] (2) Flos Lonicerae 200g, add 10 times of water, steam distill to obtain 200ml of primary liquid, then carry out redistillation, collect heavy distilled liquid 40ml;
[0062] (3) Add Houttuynia volatile oil into the double distilled liquid of honeysuckle, and keep stirring;
[0063] (4) Menthol is dissolved in an appropriate amount of ethanol, and added to the redistillate;
[0064] (5) Slowly pour Tween-80 into the heavy distillation, stirring while adding;
[0065] (6) Ethyl p-hydroxybenzoat...
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