Medicinal composition and its preparing method and use

A composition and drug technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of unfavorable exopathogen distribution, decreased bioavailability, uneven distribution of drug solution, etc., to avoid liver damage. First-pass effect, high bioavailability, stable and controllable quality

Inactive Publication Date: 2005-05-18
成都三明药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Granules and capsules are swallowed, absorbed through the gastrointestinal tract, the first-pass effect of the liver, and the bioavailability is reduced; buccal tablets are slowly released in the oral cavity, exert a long-term effect, and cannot relieve symptoms quickly; nasal drops can directly reach the lesion , to play a quick-acting effect, but because it is not easy to quantify, the liquid is not evenly distributed in the nasal cavity, and it is easy to lose from the nasal cavity, causing throat discomfort, and it is necessary to tilt the head back when administering the drug, especially not suitable for children.
[0006] The patent application No. 99115062 discloses a traditional Chinese medicine compound spray for treating acute pharyngitis and chronic pharyngitis. There are as many as 10 kinds of medicines. The distribution of evil spirits reduces the efficacy of the medicine, and it is suspected of "leaving bandits behind closed doors". Moreover, the preparation has a lot of me

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 The preparation technology of spray agent of the present invention

[0026] 1. Composition: Houttuynia cordata 250g, honeysuckle 100g, Tween-80 0.05g

[0027] Ethyl p-hydroxybenzoate 0.03g Menthol 1.5g

[0028] 2. The specific steps are:

[0029] (1) 250g Houttuynia cordata was mixed with supercritical CO 2 method to extract volatile oil;

[0030] Extraction time 50-120min, temperature 20-60℃, pressure 10-30mPa, CO 2 The flow rate is 20-50kg / h.

[0031] (2) Flos Lonicerae 100g, add 10 times of water, steam distill to obtain 200ml of primary liquid, then carry out redistillation, collect heavy distilled liquid 40ml;

[0032] (3) Add Houttuynia volatile oil into the double distilled liquid of honeysuckle, and keep stirring;

[0033] (4) Menthol is dissolved in an appropriate amount of ethanol, and added to the redistillate;

[0034] (5) Slowly pour Tween-80 into the heavy distillation, stirring while adding;

[0035](6) Ethyl p-hydroxyben...

Embodiment 2

[0040] Embodiment 2 The preparation technology of spray agent of the present invention

[0041] 1. Composition: Houttuynia cordata 600g, honeysuckle flower 350g, Tween-80 0.10g

[0042] Ethyl p-hydroxybenzoate 0.05g Orange essence 2.0g

[0043] 2. The specific steps are:

[0044] (1) 600g Houttuynia cordata was mixed with supercritical CO 2 method to extract volatile oil;

[0045] Extraction time 50-120min, temperature 20-60℃, pressure 10-30mPa, CO 2 The flow rate is 20-50kg / h.

[0046] (2) Flos Lonicerae 350g, add 10 times of water, steam distilled to obtain 200ml of primary liquid, then carry out redistillation, collect heavy distilled liquid 40ml;

[0047] (3) Add Houttuynia volatile oil into the double distilled liquid of honeysuckle, and keep stirring;

[0048] (4) Menthol is dissolved in an appropriate amount of ethanol, and added to the redistillate;

[0049] (5) Slowly pour Tween-80 into the heavy distillation, stirring while adding;

[0050] (6) E...

Embodiment 3

[0055] Embodiment 3 The preparation process of the spray of the present invention

[0056] 1. Composition: Houttuynia cordata 400g, honeysuckle 200g, Tween-80 0.08g

[0057] Ethyl p-hydroxybenzoate 0.05g Menthol 1.5g

[0058] 2. The specific steps are:

[0059] (1) 400g Houttuynia cordata was mixed with supercritical CO 2 method to extract volatile oil;

[0060] Extraction time 50-120min, temperature 20-60℃, pressure 10-30mPa, CO 2 The flow rate is 20-50kg / h.

[0061] (2) Flos Lonicerae 200g, add 10 times of water, steam distill to obtain 200ml of primary liquid, then carry out redistillation, collect heavy distilled liquid 40ml;

[0062] (3) Add Houttuynia volatile oil into the double distilled liquid of honeysuckle, and keep stirring;

[0063] (4) Menthol is dissolved in an appropriate amount of ethanol, and added to the redistillate;

[0064] (5) Slowly pour Tween-80 into the heavy distillation, stirring while adding;

[0065] (6) Ethyl p-hydroxybenzoat...

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PUM

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Abstract

The present invention provides a kind of medicine composition for treating respiratory tract infection and acute and chronic pharyngitis. It consists of cordate houttuynia, honeysuckle and pharmaceutically acceptable supplementary material. The medicine composition is prepared into oral spray and nasal spray, has functions of both resisting virus and resisting bacteria, and may be used to treat cold, pharyngitis, etc. caused by virus and bacteria.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating upper respiratory tract infection and acute and chronic pharyngitis, belonging to the field of traditional Chinese medicines. Background technique [0002] Acute upper respiratory tract infection, commonly known as "cold", is a general term for acute inflammation of the nose, pharynx, and larynx caused by viruses or bacteria. According to different causes, it can be divided into two categories: viral and bacterial. Viral infections account for about 70-80% of acute upper respiratory infections, mainly caused by rhinovirus, influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, Coxsackie virus, echovirus, coronavirus, etc. The manifestations are mostly common cold, influenza, viral pharyngitis, viral laryngitis, pharyngoconjunctival fever, herpetic angina, etc.; Haemobacteria, etc., are mostly secondary to viral infection, and a small number are d...

Claims

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Application Information

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IPC IPC(8): A61P11/00A61P11/04
Inventor 阳向波李世娟谢炜
Owner 成都三明药物研究所
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