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Soft capsule containing rhubarb, goldthread root and scutellaria root and preparation technique thereof

A technology of soft capsules and capsule shells is applied in the directions of capsule delivery, medical preparations containing active ingredients, and digestive systems, which can solve the problems of lack of content control indicators and low bioavailability of Scutellaria baicalensis, and achieve the identification and content of ingredients. Determination and other operations are simple and convenient, high bioavailability, and the effect of improving bioavailability and quality standards

Inactive Publication Date: 2005-07-06
辽宁大生商贸有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main active ingredients in Sanhuang are rhubarb anthraquinone derivatives, baicalin, and berberine hydrochloride, all of which are water-insoluble drugs with low bioavailability
The current quality standard is only the content inspection item of rhubarb, but there is a lack of corresponding content control indicators for Scutellaria baicalensis in the prescription

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Composition Parts (by weight)

[0021] Medicinal powder (according to the total amount of medicinal powder obtained at the end) 1 part

[0022] Glycerin 0.6 part

[0023] 0.2 part water

[0024] Polyethylene Glycol-6000 0.1 part

[0025] Beeswax 0.1 part

[0026] According to the above-mentioned technical scheme recipe quantity and the method thereof, the medicated powder is prepared, and it is added to the matrix prepared by this ratio, and the mixture is stirred evenly. ) Under the conditions of room temperature 25±2°C and relative humidity of 40%, compressed into soft capsules with specified drug content by automatic rotary capsule rolling machine, and dried the capsules for 20 hours under the conditions of 28±2°C and relative humidity of 40%, that is, have to.

Embodiment 2

[0028] Composition Parts (by weight)

[0029] Medicinal powder (according to the total amount of medicinal powder obtained at the end) 1 part

[0030] Isopropyl alcohol 0.34 parts

[0031] Propylene glycol 0.5 part

[0032] Agar 0.2 parts

[0033] Inositol 0.06 servings

[0034] Malic acid 0.09 part

[0035] Sorbitol 0.001 part

[0036] According to the above-mentioned technical scheme recipe quantity and its method, the medicinal powder is prepared and added to the matrix prepared by this ratio, and the mixture is stirred evenly. Under the conditions of 25±2°C and 40% relative humidity, the soft capsules with the prescribed drug content are compressed into soft capsules with the specified drug content by an automatic rotary capsule rolling machine, and the capsules are dried for 20 hours under the conditions of 28±2°C and 40% relative humidity.

Embodiment 3

[0038] Composition Parts (by weight)

[0039] Medicinal powder (according to the total amount of medicinal powder obtained at the end) 1 part

[0040] 1.3 servings of soybean oil

[0041] Tween-80 0.148 servings

[0042] Oil wax mixture 0.4 parts

[0043] Dibutylhydroxytoluene 0.148 parts

[0044] Para-hydroxybenzoic acid 0.004 parts

[0045]According to the above-mentioned technical scheme recipe quantity and its method, the medicinal powder is prepared and added to the matrix prepared by this ratio, and the mixture is stirred evenly. Under the conditions of 25±2°C and 40% relative humidity, the soft capsules with the prescribed drug content are compressed into soft capsules with the specified drug content by an automatic rotary capsule rolling machine, and the capsules are dried for 20 hours under the conditions of 28±2°C and 40% relative humidity.

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PUM

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Abstract

The disclosed soft capsule is prepared from rhubarb horsetails, goldthread root, baikal skullcap root and right amount of medicinal adjuvant, which form the content and coated into capsule shell of the soft capsule. The advantages of the capsule include convenient administration, quick action, high biological availability, and less side effects.

Description

[Technical field] [0001] The invention relates to Sanhuang soft capsule and a preparation process thereof. [Background technique] [0002] The formula of Sanhuang Soft Capsule comes from the "Xiexin Decoction" contained in the medical monograph "The Synopsis of the Golden Chamber". The three yellows in the recipe, rhubarb, coptis, and scutellaria baicalensis are all products of great bitterness and coldness. Its clinical application is widely used in Sanjiao fever, red eyes and sore eyes, sore mouth and nose, sore throat, bleeding gums, upset thirst, red urine and constipation; also used for acute gastroenteritis, dysentery, acute inflammation of the ENT organs such as throat Inflammation, acute lung infection, various inflammatory lesions in the abdominal cavity, surgical sores and swelling, chronic pelvic inflammatory disease, vaginitis, etc. [0003] The main active ingredients in Sanhuang are rhubarb anthraquinone derivatives, baicalin and berberine hydrochloride, all ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61P1/00A61P1/02A61P1/04A61P11/02A61P11/04A61P15/00A61P15/02A61P17/02
Inventor 王艳
Owner 辽宁大生商贸有限公司
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