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Obtundent-Tilidin hydrochloride preparation

A technology for tilidine hydrochloride and preparation, which is applied in the field of analgesic preparations and can solve problems such as affecting curative effect and clinical use.

Inactive Publication Date: 2006-04-12
岳振江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Affect efficacy and clinical use

Method used

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  • Obtundent-Tilidin hydrochloride preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 40 grams of tiridine hydrochloride, add 35 grams of pregelatinized starch, 15 grams of microcrystalline cellulose, 20 grams of hydroxypropyl cellulose, 40 grams of polyethylene glycol 6000, mix well, add 15% starch slurry to make Soft materials, soft materials are granulated through a 14-mesh sieve and dried at 50°C. The dry granules are granulated through a 14-mesh sieve. Add 5 grams of cross-linked carboxymethyl starch and 5 grams of magnesium stearate and mix evenly. After passing the inspection, press or fill into hard capsules. After passing the inspection, use LE coating agent to coat with film, pack in aluminum-plastic (aluminum-inscribed) and outer pack to get ready.

Embodiment 2

[0022] Weigh 30 grams of tiridine hydrochloride, add 30 grams of mannitol, and 35 grams of microcrystalline cellulose. 10 grams of cross-linked polyvinyl pyrrolidone and 15 grams of Polyethylene Glycol 4000 are mixed evenly, and 5 grams of 5% povidone absolute ethanol solution is added to make a suitable soft material, which is granulated through a 14-mesh sieve. Dry at 50°C, pass through a 14-mesh sieve, add 5 grams of croscarmellose starch sodium, 3 grams of talcum powder, and 2 grams of magnesium stearate, mix evenly, press or fill the tablets after passing the test, and use the tablet after passing the test LE coating agent coated with film, aluminum-plastic (aluminum-aluminum) package, and outer package.

Embodiment 3

[0024] Weigh 30 grams of tiridine hydrochloride. Add 20 grams of xylitol and 20 grams of sodium starch glycolate. Cross-linked polyvinylpyrrolidone 40 grams. Mix 40 grams of polyethylene glycol 6000 evenly, add 30 grams of 3% polydimensional copper anhydrous ethanol solution to make a suitable soft material, the soft material is granulated through a 14-mesh sieve, dried at 50°C, and the dry granules are granulated through a 14-mesh sieve , add 5 grams of sodium carboxymethyl starch, 3 grams of talcum powder, mix evenly, press the tablet or fill if it passes the inspection, use LE coating film coating after the tablet inspection is passed, pack in aluminum-plastic (aluminum-aluminum), and outer packaging to get final product.

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Abstract

An analgesic in the form of tablet or capsule is prepared from tilidine hydrochloride, filler, disintegrant, lubricant and adhesive.

Description

technical field [0001] The invention relates to an analgesic preparation, in particular to a preparation of the analgesic drug tilidine hydrochloride. Background technique [0002] Tiridine hydrochloride is a fully synthetic opioid analgesic drug, which acts on the central nervous system, can selectively inhibit the pain center, has no effect on other sensations, and keeps the patient conscious. It is a narcotic analgesic drug and has dependence. Pain relief for moderate to severe pain. Tiridine hydrochloride is a prodrug, which has no analgesic effect itself, and is almost completely converted into the μ-receptor agonist Nortilidine after the first-pass effect in the liver. It has the effects of analgesia, respiratory inhibition, euphoria, and physical dependence above the spinal cord. Tilidine has the advantages of low dosage, good analgesic effect and little addiction. Its analgesic mechanism is that Nortilidine, the degradation product of til...

Claims

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Application Information

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IPC IPC(8): A61K31/221A61K9/48A61P25/04
Inventor 徐进滑千里王英利赵学刚徐强岳玉敏
Owner 岳振江
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