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Prepn of lutein fally ester and lutein

A technology of fatty acid esters and lutein, which is applied in the field of preparing high-purity lutein, can solve the problems of difficult recycling, large solvent demand, and low process yield, and achieve low cost, high total yield, and process simple effect

Inactive Publication Date: 2006-08-02
EAST CHINA UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The current preparation methods that can be used for industrial production of lutein fatty acid esters and lutein are all solvent treatment methods. Due to the need for a series of dissolution, precipitation, and crystallization operations, the yield of the process is generally low, and the solvent demand Large, many types, difficult to recycle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dissolve 50 grams of lutein fatty acid ester-containing 21.2% marigold crude extract extract in 50 ml of n-hexane under stirring, and set aside after the dissolution is complete.

[0029] About 300 grams of the processed macroporous adsorption resin HZ-802 (treated according to the conventional treatment method of ion exchange resin and adsorption resin) is packed into a glass column with a diameter of 5 cm and a length of 100 cm, with a polytetrafluoroethylene piston at the lower end. The sand core at the upper end of the piston is No. 2 sand core. Pass the above-mentioned completely dissolved mixture into a glass column at room temperature, and pass it through in about 10 minutes, and then use a) 1000ml of ethanol; b) 2500ml of n-hexane: ethanol = 2:1 mixture; c) 1000ml of n-hexane Wash to get a, b, and c three-component eluent, and evaporate the solvent to dryness under reduced pressure by a rotary evaporator respectively, wherein about 9 grams of orange-red oily mat...

Embodiment 2

[0031] Dissolve 50 grams of lutein-containing fatty acid ester 21.2% marigold crude extract extract in 50 ml of petroleum ether (60-90° C.) under stirring, and wait until the dissolution is complete for later use.

[0032] About 300 grams of the processed macroporous adsorption resin HZ-816 (treated according to the conventional treatment method of ion exchange resin and adsorption resin) is packed into a glass column with a diameter of 5 cm and a length of 100 cm, and the lower end is a polytetrafluoroethylene piston. The sand core at the upper end of the piston is No. 2 sand core. Pass the above-mentioned completely dissolved mixture into a glass column at room temperature, and pass through in about 10 minutes, followed by a) 1000ml of methanol; b) 2500ml of petroleum ether (60-90°C):methanol=2:1 mixed solution; c ) with 1000ml of petroleum ether (60-90° C.) to obtain a, b, and c three-component eluent, and evaporate the solvent to dryness under reduced pressure by a rotary ...

Embodiment 3

[0034]Prepare lutein fatty acid ester 21.2% marigold crude extract dissolving mixed solution by the same method as Example 1, adopt macroporous adsorption resin as HZ-841, eluent ratio is changed to: a) methanol of 1000ml ; b) 2500ml of n-hexane: methanol is a 2: 1 mixture; c) 1000ml of n-hexane. Others were operated with the same equipment and process steps as in Example 1, b) part of the eluent could obtain 8.5 grams of orange-red solid, and the detection content was 92%. Both components a and c do not contain lutein fatty acid ester, and the solvent can be recovered under reduced pressure with a rotary evaporator.

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PUM

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Abstract

The present invention is the process of preparing lutein fatty ester from marigold extractum and preparing refined lutein product with lutein fatty ester. Marigold extractum is treated through dissolving in alkane solvent, adsorbing with macroporous adsorption resin, eluting with low toxicity mixed solvent comprising alkane and lower alcohol, rotary evaporation of the eluted liquid to recover solvent and vacuum drying, to obtain lutein fatty ester of 80-95 % content. The lutein fatty ester of 80-95 % content is further saponified under alcohol alkali condition for 2 hr, the reacted liquid is filtered, and the filter cake is washed with lower alcohol and water and vacuum dried to obtain lutein of 80-95 % purity. The process is simple and suitable for industrial production, and the solvent may be recovered and reused for low cost and environment friendship.

Description

technical field [0001] The invention relates to a biochemical separation technology, in particular to a method for preparing high-purity lutein fatty acid ester through adsorption-chromatography separation and purification, and preparing high-purity lutein through saponification. Background technique [0002] According to foreign research, lutein has the highest content in dark green leafy vegetables such as cabbage, collard greens, and spinach, as well as flowers such as calendula and marigold. Secondly, pumpkins, peaches, peppers, mangoes, and citrus are rich in lutein fatty acid esters, which are lutein fatty acid esters in the form of esterification with fatty acids such as palmitic acid, myristic acid and lauric acid. the general term for. It is a natural pigment widely found in vegetables, flowers, fruits and some algae. [0003] As early as the mid-1980s, western medical researchers discovered that the natural lutein contained in plants is ...

Claims

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Application Information

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IPC IPC(8): C07C403/24B01D15/42
Inventor 徐环昕刘坐镇宁方红沈永雷江邦和
Owner EAST CHINA UNIV OF SCI & TECH
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