Capsule for treating cardiac and cerebral vascular diseases and its preparing method and application

A technology of cardiovascular and cerebrovascular diseases and capsules, which is applied in the field of medicine, can solve the problems of easy thermal decomposition of active ingredients, incomplete extraction of active ingredients, loss of active ingredients, etc., to avoid thermal decomposition, reduce the content of impurities such as proteins, and reduce decomposition Effect

Active Publication Date: 2006-11-08
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. There is a certain loss of active ingredients during the infiltration process;
[0007] 2. When slicing, some slices are thicker, which makes the extraction of active ingredients incomplete;
[0009] 4. Use normal pressure to add ethanol, and the active ingredients are easily decomposed by heat

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Preparation of capsules of the present invention

[0040] Take 500 kg of Panax notoginseng main root, crush it with a jaw crusher PSJB-125, add 2500 kg of 50% ethanol, seal it, and soak it for 12 hours at room temperature. Then put it into a percolation tank, use 50% ethanol for percolation, collect the percolation liquid, adjust the pH to 5.0, and let stand for 12 hours. Filter with plate and frame filter CRBF-400X400, and recover ethanol under reduced pressure in ethanol recovery tower JH1200. Then concentrate the filtrate in a single-effect external circulation evaporator DN-1000 until the relative density is 1.15 to obtain a thick paste. Vacuum-dry the thick paste at 40°C and crush it to 80 meshes. Take 80g of powder, add 58g of starch and 2g of talcum powder, mix well, and pack into capsules with a full-automatic hard capsule filling machine NJP-1200D to obtain 1000 finished products.

[0041] The content of each active ingredient in the capsule obta...

Embodiment 2

[0042] Embodiment 2 Preparation of capsules of the present invention

[0043] Take 500 kg of Panax notoginseng main root, crush it with a jaw crusher PSJB-125, add 2500 kg of 60% ethanol, seal it, and soak it at room temperature for 48 hours. Then put it into a percolation tank, use 80% ethanol for percolation, collect the percolation liquid, adjust the pH to 7.5, and let stand for 24 hours. Filter with plate and frame filter CRBF-400X400, and recover ethanol under reduced pressure in ethanol recovery tower JH1200. Then, concentrate the filtrate in a single-effect external circulation evaporator DN-1000 until the relative density is 1.15 to obtain a thick paste. Dry the thick paste at 90°C and crush it to 100 mesh. Take 100g of powder, add 76g of starch and 4g of talcum powder, mix well, and pack into capsules with a full-automatic hard capsule filling machine NJP-1200D to obtain 1000 finished products.

[0044] The content of each active ingredient in the capsule obtained i...

Embodiment 3

[0045] Embodiment 3 Preparation of capsules of the present invention

[0046] Take 500 kg of the main root of Panax notoginseng, crush it with a jaw crusher PSJB-125, add 2500 kg of 70% ethanol, seal it, and soak it for 24 hours at room temperature. Then put it into a percolation tank, use 70% ethanol for percolation, collect the percolation liquid, adjust the pH to 6.5, and let stand for 48 hours. Filter with plate and frame filter CRBF-400X400, and recover ethanol under reduced pressure in ethanol recovery tower JH1200. Then concentrate the filtrate in a single-effect external circulation evaporator DN-1000 until the relative density is 1.00 to obtain a thick paste. Vacuum-dry the thick paste at 65°C, and crush it to 120 meshes. Take 80g of powder, add 100g of starch, mix well, and pack into capsules with a full-automatic hard capsule filling machine NJP-1200D to obtain 1000 finished products.

[0047] The content of each active ingredient in the capsule obtained in the pr...

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PUM

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Abstract

The present invention provides a kind of capsule for treating cardiac and cerebral vascular diseases. The capsule has effective component total arasaponin comprising ginsenoside Rg1 10.0-80.0%, ginsenoside Rb1 10.0-87.0% and arasaponin R1 2.0-75.0%. The preparation process includes the following steps: crushing axial root of notoginseng and soaking in ethanol; percolating in ethanol and regulating pH to 5.0-8.0 and stilling; filtering and decompression concentrating to recover ethanol; drying and crushing extractum; adding supplementary material and encapsulating. The capsule is used in treating cardiac and cerebral vascular diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a capsule for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Panax notoginseng is a perennial herb of Araliaceae, containing a variety of plant saponins, which have the functions of dilating blood vessels and inhibiting platelet aggregation. [0003] The medicine made from Panax notoginseng extract has clinical functions of promoting blood circulation and removing blood stasis, increasing blood flow of cerebral arteries and coronary arteries, lowering blood lipids, and improving microcirculation functions. It can be used to treat cardiovascular and cerebrovascular diseases, stroke hemiplegia, Blood stasis syndrome and cerebral embolism disease. [0004] The preparation process of traditional Panax notoginseng saponins capsules is as follows: take Panax notoginseng roots, wash, infiltrate, slice, put them into the extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/48A61K36/258A61P3/06A61P9/10
Inventor 方同华王春生
Owner HARBIN ZHENBAO PHARMA
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