Prepn. of self-emulsion of glossy ganoderma spore oil, and its prepn. method

Abstract

A self-emulsified ganoderma spore oil in the form of soft capsule, liquid soft capsule, capsule, particle, etc is prepared from ganoderma spore oil, carrier, emulsifier, emulsifying assistant and/or adsorbent. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a self-emulsifying preparation of ganoderma lucidum spore oil and a preparation method thereof. Background technique [0002] Ganoderma lucidum spore oil is a hydrophobic oily substance extracted from Ganoderma lucidum spores. Ganoderma lucidum spores are the spores released from the cap of Ganoderma lucidum during the mature period. Since the 1980s, there have been more basic researches on the anti-tumor aspects of Ganoderma lucidum and its spores; in the 1990s, the United States, Japan and other countries have applied Ganoderma lucidum to Clinically, it is used in the treatment of cancer and AIDS (AIDS), and has received extensive attention from international research scholars. In recent years, more studies and applications have been made on artificially cultivated ganoderma lucidum spores and their extracts. The main components of ganoderma lucidum spo...

AI Technical Summary

Problems solved by technology

For example, the temperature, emulsification time and production equipment of the intravenous emulsion injection process are likely to affect the product quality and cause uneven emulsion particles; the product quality is unstable, and oil and water stratification, cracking, phase inversion, and flocculation are prone to occur during storage and spoilage; the storage conditions are relatively harsh, and they should be kept away from light, filled with nitrogen, and stored at a lower temperature; the service life is short, only 1 to 1 and a half years, and it is greatly affected by the environment in actual use, often within the validity period That is, failure or unqualified properties, etc.

Ganoderma lucidum spore oil oral emulsion is also a thermodynamically unstable system, especially after undergoing the same sterilization process as the injection, its physical stability is poor, the process and product quality are not stable, and the taste of Ganoderma lucidum spore oil oral emulsion is poor, fishy smell and greasiness

What is particularly unfavorable is that chemotherapy and radiotherapy usually induce vomiting in patients, and taking oral emulsion of ganoderma lucidum spore oil will further aggravate this pain and significantly reduce the patient's treatment compliance, which is not conducive to the smooth development of clinical treatment.

[0004] Due to the physicochemical properties of Ganoderma lucidum spore oil, it is very suitable to be made into soft capsules, yet some difficulties need to be overcome when making Ganoderma lucidum spore oil into soft capsules, such as disintegration during storage becomes unqualified, material migration and Stability issues such as leakage of oily components, increased acid value and oxidation value