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Selective adsorbent low density lipoprotein cholesterol and method for preparing same

A low-density lipoprotein and cholesterol technology, which is applied in the fields of chemical synthesis and protein bioseparation engineering, can solve the problems of complex and cumbersome treatment systems, high technical confidentiality costs, and increased treatment costs, achieving reduced treatment costs, low production costs, Raw material rich effect

Inactive Publication Date: 2007-03-07
CHONGQING UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

Therefore, a cation adsorption column must be added during the treatment to remove excess heparin units. After the treatment, protamine must be added to neutralize the residual heparin as needed, making the treatment system more complicated and cumbersome, increasing the treatment cost, and at the same time It also makes this method have room for improvement in terms of security.
In addition, this method also has the shortcomings of technical secrecy and high cost.

Method used

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Examples

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Embodiment Construction

[0035] Now in conjunction with embodiment, the present invention will be further described.

[0036] Implementation Example 1 Take the artificially synthesized macromolecular substance polyvinyl alcohol as a carrier, and take dialdehydes (glutaraldehyde) as a coupling agent as an example:

[0037] Take 15g of polyvinyl alcohol, add 25g of glutaraldehyde, then add 600μL of strong acid catalyst hydrochloric acid and 80mL of solvent cyclohexane, and then stir and react at reflux temperature of 78°C for 6-8 hours. After the reaction is completed, filter, wash repeatedly with clean water several times, filter dry, then add 30 mL of distilled water and 400 μL of weak acid catalyst acetic acid, and finally add 2 mg of heparin, and shake gently below 60 ° C for 10 to 12 hours. After the reaction is finished, wash with water repeatedly, filter and dry, and air-dry below 60°C to obtain the product.

[0038] Implementation example 2 takes artificially synthesized polymer polyvinyl alcoh...

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PUM

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Abstract

The invention relates to a selective absorber of low-density lipoprotein cholesterol, which comprises carrier and functional group. Wherein, the carrier is macromolecule whose surface has free function group hydroxyl and / or amido; the functional group comprises disebrin and its derivate, or one of ateroid; the functional group via coupler is fixed on the carrier. The invention also provides relative production that selecting the macromolecule with surface function group as carrier, uses conjugated linkage to fix functional group, keeps active group carboxyl and sulfonic group, to keep the function group of specific adsorption LDL and, and hold the material from dropping in application, to improve safety. The invention has low cost and simple process.

Description

technical field [0001] The invention belongs to the field of chemical synthesis and protein bioseparation engineering, and particularly relates to an adsorbent with heparin as a ligand used in blood purification to selectively adsorb and remove low-density lipoprotein cholesterol, and the invention also relates to the adsorbent method of preparation. technical background [0002] Blood purification therapy is an unconventional clinical treatment method that has appeared since the 1980s. It is mainly a unique treatment method for certain diseases by removing certain pathogenic substances in the blood. Its essence is biological Application of separation technology in the medical field. With the development of biological separation technology and biological materials, blood purification treatment technology has also made great progress. The blood purification therapy is characterized by establishing a temporary human blood circulation branch outside the body, so that the bloo...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/24C07K1/22
Inventor 麻开旺王翔蔡绍皙江卫宁高玮田学隆
Owner CHONGQING UNIV
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