Prepn process of nanometer calcium phosphat particle

Abstract

The preparation process of nanometer calcium phosphate particle includes the following steps: dropping solution containing calcium ion slowly into mixed solution containing phosphate radical ion and cetyl trimethyl ammonium bromide (CTAB), dropping alkali solution to regulate pH value of the solution to obtain calcium phosphate sol, filtering after reaction to obtain precipitate, washing the precipitate for several times, and vacuum drying to obtain nanometer calcium phosphate particle of average size smaller than 100 nm. Altering the amount of added CTAB during reaction can change the diameter of the prepared nanometer calcium phosphate particle in 20-80 nm effectively.

Description

Technical field: [0001] The invention discloses a preparation method for preparing size-controllable calcium phosphate nanoparticles, which belongs to the technical field of new materials. Background technique: [0002] Calcium phosphate is basically the same as the inorganic components of human hard tissues, and its biocompatibility and interface bioactivity are superior to all kinds of medical titanium, silicone rubber and carbon materials for bone grafting. It also has excellent osteoconductivity and bone The ability to combine, plus no toxic side effects, no carcinogenic effect, so it is widely used as hard tissue repair materials and bone filling materials. With the development of detection technology and nanoscience, it has recently been found that human hard tissue is composed of many calcium phosphate particles with a size smaller than 50 nanometers uniformly dispersed in organic components. In addition, new uses of nano-calcium phosphate have also been continuously...

AI Technical Summary

Problems solved by technology

At present, the methods used to prepare nano-calcium phosphate mainly include sol-gel method, solid-phase reaction method, hydrothermal method, etc. The calcium phosphate prepared by these methods is usually in the shape of flakes, needles, rods or irregular particles, and the size is uniform. Greater than 100 nanometers, and the agglomeration phenomenon is serious, and monodispersion cannot be achieved

The microemulsion method and normal phase micelle method proposed subsequently can artificially control the shape and size of the synthesized particles to a certain extent, and the dispersibility of the prepared powder is better. For example: Bose and Saha: Susmita Bose ; SusantaKumar Saha Chem.Mater.2003,15,4464-4469, take NP-5 and NP-12NP-5 as (poly(oxyethylene)5nonylphenol ether; NP-12 is poly(oxyethylene)12 nonylphenol ether) as surfactant , with cyclohexane as the oil phase, Ca(NO 3 ) 2 and H 3 PO 4 As a reactant, the microemulsion method is used to synthesize HAP with a particle size between 30nm and 50nm, needle-like, sheet-like and spherical shapes. However, this type of preparation method has high cost and low yield, and how to introduce a large amount of The complete removal of organic matter has become a new problem in the material preparation process; while Yao Jia et al., Masafumi Uota; Hiroshi Arakawa; Nana Kitamura; Takumi Yoshimura; Junzo Tanaka; Alkyltrimethylammonium bromide (CTAB) is a cationic surfactant, and short rod HAP particles with a thickness of 50-100nm and a length of 500-1000nm were synthesized by the normal phase micellar method

Their work showed that using CTAB as a surfactant can effectively control the morphology of the prepared calcium phosphate particles, but they did not systematically explore the mechanism of CTAB’s morphology control during the synthesis process, thus ignoring the According to the critical micelle concentration (CMC) theory, the important content of the size and morphology of calcium phosphate particles can be better regulated