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In-vivo real-time photo-sensitive blood pH value sensor and its making method

A ph sensor, time technology, applied in the field of medical equipment and materials, to achieve the effect of rapid response, stable performance and long service life

Inactive Publication Date: 2007-04-18
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defects of the current pH detection equipment, to provide a real-time light-sensitive blood pH sensor in vivo and its preparation method

Method used

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  • In-vivo real-time photo-sensitive blood pH value sensor and its making method
  • In-vivo real-time photo-sensitive blood pH value sensor and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dissolve 30 grams of MPC, 68 grams of butyl methacrylate, 2 grams of γ-(methacryloyloxy)propyltrimethoxysilane and 0.1 gram of initiator AIBN in absolute ethanol, and slowly introduce argon for 1 hour deoxygenation. Then place it in a constant temperature water bath at 70° C., and react under stirring for 24 hours. After the reaction was completed, the solution was cooled to room temperature and purified twice by precipitation with a large amount of n-hexane; the collected precipitate was vacuum-dried at room temperature for 24 hours. 90 grams of copolymers containing phospholipid groups were obtained.

[0022] Dissolve 50 mg of BCECF in 10 ml of methanol, and dissolve 0.4 g of the above-mentioned copolymer containing phospholipid groups in the same solution. After filtering, add 20 microliters of water to the resulting solution, stir evenly, and apply the solution on the optical fiber. The end is heat-treated in a 70-degree oven for 5 hours to volatilize the solvent ...

Embodiment 2

[0024] 15 grams of MPC, 10 grams of polyethylene glycol (molecular weight 360) methyl ether methacrylate, 10 grams of ethylene glycol methyl ether methacrylate, 63 grams of dodecyl methacrylate, 2 grams of γ-( Dissolve methacryloyloxy)propyltrimethoxysilane and 0.1 g of initiator AIBN in anhydrous ethanol / tetrahydrofuran (volume ratio 50 / 50) solution, and slowly pass through argon gas for 1 hour to remove oxygen. Then place it in a constant temperature water bath at 70° C., and react under stirring for 24 hours. After the reaction was completed, the solution was cooled to room temperature and purified twice by precipitation with a large amount of n-hexane; the collected precipitate was vacuum-dried at room temperature for 24 hours. 92 grams of copolymers containing phospholipid groups were obtained.

[0025] Dissolve 30 mg of BCECF in 5 ml of methanol, and dissolve 0.2 g of the above-mentioned copolymer containing phospholipid groups in the same solution. After filtering, add...

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Abstract

An in-body real-time photosensitive blood pH sensor is prepared from an ordinary optical fiber and an pH sensing film composed of the luminous electrochemical substance with high sensitivity to pH and the polymer containing phosphatide group through coating said pH sensing film on the terminal of said optical fiber. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medical equipment and materials, in particular to an in vivo real-time light-sensitive blood pH sensor and a preparation method thereof. Background technique [0002] The development of modern medicine, especially the rescue of clinical critically ill patients, requires long-term minimally invasive real-time detection of various parameters of the human body, including blood pH. At present, the pH measuring instrument is mainly based on the electrode method. It has the problem that the sensor and the blood contact with the blood for a certain period of time, and the surface is adhered by platelets and other proteins to cause failure. In other fields such as bioreactors Sensors for other applications also have similar biological contamination problems. [0003] Phosphorylcholine is the main component of the phospholipid head in the outer layer of biological cell membranes. Polymers containing phosphorylcholine group...

Claims

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Application Information

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IPC IPC(8): A61B5/145G01N33/48C08L33/04C08K5/541
Inventor 白春学蒋进军钟伟宋元林
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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