Method for increasing the rate and consistency of bioavailability of supplemental dietary ingredients

a technology of supplemental dietary ingredients and bioavailability, which is applied in the direction of drug compositions, dispersed delivery, metabolic disorders, etc., can solve the problems of not only presenting a problem in terms of bioavailability but also in terms of reducing or preventing, and achieves the effect of improving the immediacy of absorption of said supplemental dietary ingredients, and increasing the rate of bioavailability

Inactive Publication Date: 2007-08-30
MULTI FORMULATIONS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0004] The present invention relates to a method for increasing the rate of bioavailability of supplemental dietary ingredients in mammals. The rate of bioavailability is increased via a narrowing of particle size range and a concomitant reduction in the average particle size, improving the immediacy of absorption of said supplemental dietary ingredient. A further aspect of the present invention is to improve the consistency of dissolution, and thus the absorption of orally administered supplemental dietary ingredients.

Problems solved by technology

This not only presents a problem in terms of bioavailability but also in terms of reducing or preventing toxicity and irregular absorption in the intestinal tract (Shekunov B Y, Chattopadhyay P, Seitzinger J, Huff R. Nanoparticles of poorly water-soluble drugs prepared by supercritical fluid extraction of emulsions.
Therefore, it is a challenge to make these compounds, which will be used in a biological system, e.g., orally ingested by a human, such that they will be more readily bioavailable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

In Powdered Form

[0073] A dietary supplement comprising the following ingredients per serving is prepared for consumption one time per day per individual:

[0074] about 2.0 ng of fine-milled Glycine, about 2.0 g of regular Glycine, about 5.0 ng of fine-milled L-Arginine, about 5.0 g of regular L-Arginine, about 3.0 ng of fine-milled Calcium-KIC, about 3.0 g of regular Calcium-KIC, about 2.0 g of Maltodextrin, about 1.5 g of Citric Acid, about 80 g of Dextrose, about 0.5 g of Sodium Citrate, about 0.3 g of Sodium Gluconate, about 0.4 g of Polyvinylyrolidone, about 0.1 g of Modified Food Starch, about 0.4 g of Syurp Solids, about 0.03 g of Gum Acacia, about 0.05 g of Silicon Dioxide, about 0.027 g of Acesulfame-Potassium, and about 0.01 g FD&C Red #40.

[0075] Preferably, the nutritional composition is consumed in accordance with the following directions:

[0076] Directions: As a dietary supplement, take one serving (35 g) of product before a high-intensity workout. Mix in a shaker cup ...

example 2

[0081] A dietary supplement comprising the following ingredients per serving is prepared for consumption one to four times per day per individual:

[0082] about 7.5 g Leucine, about 0.0004 g fine-milled Leucine, about 0.05 g Calcium-KIC, about 0.45 g Hydroxyprpoyl Cellulose, about 1.75 g Microcrystalline Cellulose, about 0.18 g Croscarmellose Sodium, about 0.03 g Calcium Carbonate, about 0.12 g Vegetable Stearine, about 0.06 g Magnesium Stearate, about 0.06 g Silica, about 0.03 g Magnesium Silicate, about 0.306 g Coating [Polyvinyl Alcohol, Polyethylene Glycol, Talc, Titanium Dioxide, Riboflavin, Soy Lecithin, Polysorbate 80, Hydroxypropyl methylcellulose, Colorings], about 0.001 g Lysine Ketoisocaproic Acid and about 0.0004 g Sweeteners.

[0083] Preferably, the nutritional composition is consumed in accordance with the following directions:

[0084] Directions: As a dietary supplement, take 1 serving (6 caplets) first thing in the morning. On workout days, take 1 serving immediately be...

example 3

[0085] A dietary supplement comprising the following ingredients per serving is prepared for consumption one to four times per day per individual:

[0086] about 2.0 g regular Creatine-Ethyl Ester HCl, about 0.001 g fine-milled Creatine-Ethyl Ester HCl, about 0.1 g Creatine Alpha-ketoglutarate and about 0.1 g Alpha-lipoic Acid.

[0087] Preferably, the nutritional composition is consumed in accordance with the following directions:

[0088] Directions: As a dietary supplement, take two servings per day, e.g., one serving (2 caplets) in the morning and one serving (2 caplets) in the afternoon. Consume 10 8 oz. Glasses of water daily. To maximize results, use in conjunction with weight training.

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Abstract

The present invention relates to a method for increasing the rate of bioavailability of orally administered supplemental dietary ingredients through the process of fine-milling to increase the rate of dissolution of the ingredients. The ingredients to be fine-milled are ingredients suitable for use in supplemental dietary compositions.

Description

RELATED APPLICATIONS [0001] The present application is related to and claims benefit of priority to U.S. Provisional Application No. 60 / 776,325, entitled “Compositions and method for increasing the rate of bioavailability of supplemental dietary ingredients” filed Feb. 23, 2006, the disclosure of which is hereby fully incorporated by reference.FIELD OF THE INVENTION [0002] The invention relates to the process of particle milling, micronization, for the purposes of increasing the rate of bioavailability following oral administration of components comprising supplemental dietary compositions. The compositions and methods promote increased rate of bioavailability by increasing the total surface area of poorly soluble particles, thereby increasing the rate of absorption. BACKGROUND OF THE INVENTION [0003] Poorly-soluble compounds are described as either sparingly soluble or insoluble in polar or non polar solvents depending on the hydrophilicity of lipophilicity of said compunds. Many c...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/20A23L5/30A23L33/00
CPCA23L1/30A23L1/3002A23L1/304A23L1/3051A23L1/3053A23L2/52A23V2002/00A61K9/0095A61K9/14A61K9/20A61K9/2072A61K31/122A61K31/185A61K31/197A61K31/198A61K31/205A61K31/385A61K31/4045A61K31/455A61K31/555A61K31/715A61K33/24A61K33/42A61K36/185A61K36/53A61K36/539A61K36/752A61K36/76A61K36/84A61K36/889H01L21/28273H01L29/42324H01L29/788H01L29/7884Y10S514/923A61K2300/00A23V2200/20A23V2250/0606A23V2250/7046A23V2200/326A23V2200/316A23V2250/06A23V2250/0644A23V2250/21A23L33/10A23L33/105A23L33/16A23L33/175A23L33/18H01L29/40114A61P21/06A61P25/20A61P3/02A61P43/00
Inventor HEUER, MARVINCLEMENT, KENCHAUDHURI, SHAN
Owner MULTI FORMULATIONS LTD
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