Composition and method for managing redness of skin associated with dermatological condition

Abstract

The present invention is directed towards a topical composition for managing redness of skin associated with a dermatological condition, comprising water, gelled ethyl alcohol (an anti-bacterial), anti-oxidants, thickening agents, emulsifiers, stabilizers, and a natural esterified anti-inflammatory (Hepes). This combined therapy is more effective than anti-bacterial agents alone and is particularly effective for those who do not respond well to the solutions containing only anti-bacterial agents.

Description

BACKGROUND OF INVENTION [0001] The present invention relates to the treatment of a dermatological condition and, more specifically, to the treatment of rosacea, by a topical application of a composition comprising a combination of gelled ethyl alcohol and Hepes Linoleate. The invention relates to topical compositions for the treatment of a dermatological condition and, more specifically, to the treatment of rosacea. The method for treatment preferably includes two to three applications daily to the affected area of the skin. [0002] Rosacea is a chronic inflammatory skin disorder that can develop in the third to sixth decade of life characterized by four distinct clinical stages predominately affecting the central aspect of the face. The disease appears to be more prevalent in northern climates where cold exposure is experienced more often, and in light-skinned persons on whom flushing is common and sensitivity to sunlight is particularly high. The first clinical evidence of rosacea ...

AI Technical Summary

Benefits of technology

[0009] U.S. Pat. No. 5,994,330, El Khoury, issued Nov. 30, 1999, describes the treatment of acne and other inflammatory skin conditions using topically administered muscarinic agents. The therapeutic effects of the invention are said to include a decrease in redness, swelling and inflammation.

[0010] U.S. Pat. No. 5,968,532, De Lacharriere, et al., issued Oct. 19, 1999, describes the use of an ethylene diamine derivative in a cosmetic or dermatological composition containing a material having an irritant side effect. The ethylene diamine derivative is said to minimize skin irritation, erythema and sensations of inflammation or rosacea stemming from the use of the cosmetic / dermatological product.

[0011] U.S. Pat. No., 5,885,595, Corey, et al., issued Mar. 23, 1999, describes a cosmetic composition which includes a retinal fatty acid ester. The composition is said to be effective for treating chronoaging conditions of the skin and dermatological disorders including acne, follicular and lesional papules, actinic kertoses, oily skin and rosacea.

[0012] U.S. Pat. No. 6,071,541, Murad, issued Jun. 6, 2000, describes the use of a topical composition which contains a hydroxy acid or tannic acid to exfoliate a portion of the skin, stabilized hydrogen peroxide to facilitate cleansing of the skin, and an antimicrobial agent to inhibit or reduce microorganisms of the skin. The composition is said to be effective in the treatment and management of inflammatory skin conditions, such as acne and acneiform rosacea.

[0013] U.S. Pat. No. 6,057,341, Charpentier, issued May 2, 2000, describes pharmaceutical or cosmetic composition which include novel bi-aromatic dibenzofuran derivatives. The compositions are said to exhibit pharmacological responses of the retinoid agonist type and are further said t be effective in treating keratinization disorders, including acne rosacea.

[0014] U.S. Pat. No. 5,886,233, Steinmeyer, et al., issued Mar. 23, 1999, describes cyclohexanone derivatives used to synthesize vitamin D compounds. The compounds are said to be useful for treating skin, such as in the treatment of acne.

Problems solved by technology

Systemic and topical antibiotics include tetracycline, metronidazole, erythromycin, minocycline, and clindamycin, but the use of these agents is often accompanied by drug side effects, the development of resistance, and changes in the normal microbial flora.

Retinoids are often irritants and are not advised for individuals with sensitive skin.

Retinoids can also be phototoxic and they can induce thin and easily bruisable, fragile skin.