171 results about "MET Receptor Tyrosine Kinase" patented technology

The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.

Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.

The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.

The invention provides methods and compositions for modulating the HGF / c-met signaling pathway, in particular by regulating binding of HGF β chain to c-met.

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and / or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Aspects of the invention relate to methods and compositions for treating cancers associated with constitutive EGFR signaling. Methods include inhibiting one or more components of the c-Met and / or Axl signaling pathways. Aspects of the invention also relate to methods for determining whether a subject is a candidate for treatment with an inhibitor of a c-Met and / or Axl signaling component.