The invention relates to an electronic device and a method for operating screen. The electronic device, comprises: a screen being capable of displaying a working window and an executing window, a user interface module, wherein when a pointer is positioned on the executing window, the user interface module generates a first sensing signal for displaying at least one item on the screen, when the pointer selects the item, the user interface module generates a second sensing signal, and when the pointer drags the item to the working window, the user interface module generates a third sensing signal; and a processing module for continuously receiving the first, second and third sensing signals that are sequentially generated by the user interface module to open a user interface corresponding to the item in the working window, wherein the user interface is adjacent to the pointer. The electronic device and the method for operating screen accords with the operation mode of the human engineering and increases the use convenience.