The application relates to the technical field of external preparation, and discloses a Xing-guan-guo
nervonic acid external anti-
psoriasis bacteriostatic cream and a preparation process thereof. The cream is prepared from Xing-guan-guo
nervonic acid, behenyl
alcohol,
isostearic acid, cetyl
stearyl glucoside,
octyldodecanol,
dicaprylyl carbonate and
purified water. In the formula, the steric hindrance of
octyldodecanol is used in cooperation with the polar dispersing force of
dicaprylyl carbonate to keep the
nervonic acid molecules in a
free state and inhibit the
crystallization and
precipitation of the nervonic acid molecules in the cooling process. The behenyl
alcohol and the
isostearic acid in the
system self-assemble to form a biomimetic lamellar
liquid crystal framework at the oil-water interface under the guidance of the cetyl
stearyl glucoside. The application solves the technical problem of high cohesion and easy aggregation of the nervonic acid, the constructed
liquid crystal phase structure is compatible with the
skin keratin layer lipid, the transdermal
diffusion resistance of the effective component is reduced, and the long-term
physical stability and the anti-
psoriasis efficacy of the cream are improved.