2results about How to "Reduce fusion" patented technology

This invention relates to the application of mitochondrial formulations in the preparation of drugs for treating chronic obstructive pulmonary disease (COPD). The mitochondrial formulations contain active mitochondria isolated from healthy donor cells, with a particle size of 400–1000 nm, possessing normal mitochondrial membrane potential and ATP generation function, and capable of being internalized by mammalian COPD lung epithelial cells. In vitro cell experiments have confirmed that this mitochondrial formulation can repair CSE-induced mitochondrial dysfunction in lung epithelial cells, inhibit mPTP opening, reduce mtDNA leakage into the cytoplasm, thereby blocking the activation of the cGAS-STING signaling pathway and reducing the release of inflammatory factors such as IL-1β and TNF-α. In vivo experiments in COPD mouse models show that tail vein injection of the mitochondrial formulation can effectively accumulate in lung tissue, significantly improving lung pathological changes such as emphysema and collagen fiber deposition in model mice. This invention provides a novel strategy for COPD treatment based on repairing mitochondrial function and intervening in inflammatory signaling pathways.

The application relates to the technical field of environment-friendly regenerated material production equipment, in particular to an environment-friendly regenerated material double-screw extruder and method, which comprises a feeding driving mechanism, a feeding extruding mechanism, a mixing driving mechanism and a mixing extruding mechanism. The feeding driving mechanism is used for driving the feeding extruding mechanism, the mixing driving mechanism is used for driving the mixing extruding mechanism, the feeding extruding mechanism is used for feeding materials, the feeding extruding mechanism comprises a feeding tank body, a feeding fixing support, a feeding main screw, a feeding driven screw and a feeding connecting seat, both ends of the feeding tank body are respectively provided with a feeding port and a discharging port, and the discharging port is used for connecting the mixing extruding mechanism. The feeding main screw in the grinding channel and the feeding driven screw work cooperatively, not only realizing the stable conveying of the materials from the feeding port to the discharging port, but also efficiently grinding the materials in the conveying process, which is helpful to improving the dispersivity and uniformity of the materials.