7results about How to "Reduce fusion" patented technology

The invention relates to the technical field of communication services, and particularly discloses a cloud native architecture service concurrency performance optimization method and device, equipment and a medium, and the method comprises the steps: determining a to-be-optimized combined scene service under a cloud native architecture; and performing service thread resource reuse, service-level thread concurrent processing and data interaction frequency reduction processing on the to-be-optimized combined scene service to realize service concurrent performance optimization of the to-be-optimized combined scene service. According to the method, the communication efficiency of the microservice architecture complex scene service can be improved, so that the fusing of a microservice system triggered by a single service is reduced as far as possible, and high-availability, high-availability and high-concurrency service capabilities are continuously provided for a terminal user; the problem of an internet-based scene-based business fusion development mode is solved, and the concurrency response efficiency of cloud native architecture services is improved.

The invention belongs to the technical field of medicines, and provides application of polypeptide in preparation of a disseminated intravascular coagulation drug. The amino acid sequence of the polypeptide is as follows: Ala-Glu-Pro-Val-Pro-Leu. Experiments show that the polypeptide can obviously prolong the survival time of a diffuse intravascular coagulation model rat to a certain extent, reduce the bleeding score of visceral organs, especially lungs, of the diffuse intravascular coagulation model rat, reduce pulmonary alveolar wall capillary thrombosis and inflammatory cell infiltration, and reduce the proportion of large and medium pulmonary artery thrombosis, so that the polypeptide can be used for treating pulmonary thrombosis. And alveolar fusion is reduced, and the compound has a certain application prospect in preparation of dispersive intravascular coagulation drugs.

The application provides a kind of multimodal attention and feature fusion framework for remote sensing image fusion, belongs to remote sensing information processing technical field, including five layers encoder-decoder architecture, the architecture includes hybrid attention and multiscale fusion (HAMF) module, adversarial feature fusion (AFF) module and cross-domain regularization (CDR) module.The application preprocesses the hyperspectral, multispectral image of input through the framework;Through HAMF module, feature extraction and enhancement are carried out;Through AFF module, feature alignment, information maximization and adversarial optimization are carried out;Through CDR module, domain adversarial training and regularization operation are carried out, the cross-domain generalization ability of the framework is improved, finally a composite loss function is constructed to train the whole framework end to end, and iteration is carried out until convergence, so that each evaluation index of the fusion image is obviously improved, and the fusion image with high-quality spectral information and clear spatial details is output.

This invention relates to the application of mitochondrial formulations in the preparation of drugs for treating chronic obstructive pulmonary disease (COPD). The mitochondrial formulations contain active mitochondria isolated from healthy donor cells, with a particle size of 400–1000 nm, possessing normal mitochondrial membrane potential and ATP generation function, and capable of being internalized by mammalian COPD lung epithelial cells. In vitro cell experiments have confirmed that this mitochondrial formulation can repair CSE-induced mitochondrial dysfunction in lung epithelial cells, inhibit mPTP opening, reduce mtDNA leakage into the cytoplasm, thereby blocking the activation of the cGAS-STING signaling pathway and reducing the release of inflammatory factors such as IL-1β and TNF-α. In vivo experiments in COPD mouse models show that tail vein injection of the mitochondrial formulation can effectively accumulate in lung tissue, significantly improving lung pathological changes such as emphysema and collagen fiber deposition in model mice. This invention provides a novel strategy for COPD treatment based on repairing mitochondrial function and intervening in inflammatory signaling pathways.

The invention belongs to the technical field of medicines, and provides application of a polypeptide in preparation of a disseminated intravascular coagulation drug. The amino acid sequence of the polypeptide is Pro-Ala-Ala-Glu-Pro-Val-Pro-Leu, and the amino acid sequence of the polypeptide is shown in the specification. Experiments show that the polypeptide can obviously prolong the survival time of a diffuse intravascular coagulation model rat to a certain extent, reduce the bleeding score of visceral organs, especially lungs, of the diffuse intravascular coagulation model rat, reduce pulmonary alveolar wall capillary thrombosis and inflammatory cell infiltration, and reduce the proportion of large and medium pulmonary artery thrombosis, so that the polypeptide can be used for treating pulmonary thrombosis. And alveolar fusion is reduced, and the compound has a certain application prospect in preparation of dispersive intravascular coagulation drugs.

The application relates to the technical field of environment-friendly regenerated material production equipment, in particular to an environment-friendly regenerated material double-screw extruder and method, which comprises a feeding driving mechanism, a feeding extruding mechanism, a mixing driving mechanism and a mixing extruding mechanism. The feeding driving mechanism is used for driving the feeding extruding mechanism, the mixing driving mechanism is used for driving the mixing extruding mechanism, the feeding extruding mechanism is used for feeding materials, the feeding extruding mechanism comprises a feeding tank body, a feeding fixing support, a feeding main screw, a feeding driven screw and a feeding connecting seat, both ends of the feeding tank body are respectively provided with a feeding port and a discharging port, and the discharging port is used for connecting the mixing extruding mechanism. The feeding main screw in the grinding channel and the feeding driven screw work cooperatively, not only realizing the stable conveying of the materials from the feeding port to the discharging port, but also efficiently grinding the materials in the conveying process, which is helpful to improving the dispersivity and uniformity of the materials.

The invention discloses a pH-sensitive liposome for entrapment of a cell culture additive and a preparation method of the pH-sensitive liposome, and relates to the technical field of pH-sensitive liposomes. According to the invention, nutrient substances such as glucose, amino acid and glutamine and pH regulators such as NaOH and NaHCO3 required in the middle and later periods of cell growth are prepared into pH-sensitive lipidosome, the substances are respectively wrapped in cavities of the lipidosome, and after the pH of a cell growth solution system is reduced, the substances can be respectively released to be beneficial to improving the growth state of cells, improving the cell growth state and improving the cell growth efficiency. The pH balance of the cell growth liquid can be realized, and the cell growth liquid is kept neutral. The prepared pH sensitive liposome is uniform in size, good in dispersity, stable in structure in a neutral solution and capable of being effectively split in an acid solution, and the growth state of cells can be improved after the pH sensitive liposome is loaded with nutrient substances and a pH regulator. The pH-sensitive lipidosome can be added with substances required by cell culture in a manner of not opening a cell culture container, so that the risk of cell pollution is reduced.